Fabrication of a pH-Responsive 5-FU@MSN-SA Nanoplatform for Anti-Tumor Activity

Abstract

Design of high-performance drug delivery system is necessary to improve the anticancer ability of 5-fluorouracil (5-FU). In this work, we developed a pH-responsive 5-FU loaded and sodium alginate (SA) modified mesoporous silica nanoparticles (MSNs) drug delivery system (5-FU@MSN-SA). After 5-FU was loaded into the pores, MSNs were successfully functionalized with amino groups and then capped by sodium alginate. Compared to acidic conditions, the drug release rate in the neutral environment was quite low. Moreover, detailed investigations confirmed that 5-FU@MSN-SA can easily be up-taken by cancer cells and proved the high cytotoxicity to 4T1 cells. The calculated IC[Formula: see text] values for 5-FU and 5-FU@MSN-SA were 34.67[Formula: see text][Formula: see text][Formula: see text]g/mL and 54.95[Formula: see text][Formula: see text][Formula: see text]g/mL, respectively. These results indicated that 5-FU@MSNs-SA can be a promising nanoplatform in cancer therapy.

A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis

“…The standard curves of 5-Fu and ICG were used to calculate the loading efficiency. 46 pH affects the drug release due to the acidic tumor microenvironment; hence, the physiological environment of pH values of 5.5, 6.5, and 7.4 was simulated in vitro . A parallel group of 5-Fu/ICG@ZPZ samples was dispersed in dialysis bags containing PBS (2 mL) with different pH values (5.5, 6.5, and 7.4).…”

Redox-responsive mesoporous silica nanoparticles for chemo- photodynamic combination cancer therapy

“…The MSN was synthesized as previously reported [30,42]. Figure 1(a) is a representative scanning electron microscope (SEM) image of MSN, showing the synthesized MSN as spherical particles with uniform size, smooth surface, and good monodispersity.…”

“…The MSN was synthesized as previously reported [30,42]. 0.5 g of CTAB and 0.14 g of NaOH (molar ratio=0.39:1) were placed into deionized water (250 ml).…”