Fabrication of a self-assembled honeycomb nanofibrous scaffold to guide endothelial morphogenesis

Yao, Tianyu; Wieringa, Paul; Chen, Honglin; Chandrakar, A.; Samal, Pinak; Giselbrecht, Stefan; Baker, Matthew B.; Moroni, Lorenzo

doi:10.1088/1758-5090/ab9988

Cited by 14 publications

(12 citation statements)

References 81 publications

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“…Various fibrous architectures have been reported in the literature for different tissue engineering applications. While the mechanical properties of the scaffolds significantly depend on the internal design, [61][62][63] the foreign body reaction to the implanted PCL mesh is also an important factor to be considered. [64] In this study, the current internal architecture of MEW PCL scaffolds was chosen in a way to induce enough mechanical reinforcement, while the surface of PCL mesh is at minimum to reduce the risk of severe foreign body reaction.…”

Section: Mechanical Properties and Swelling Behaviormentioning

confidence: 99%

3D Fiber Reinforced Hydrogel Scaffolds by Melt Electrowriting and Gel Casting as a Hybrid Design for Wound Healing

Afghah

Iyison

Nadernezhad

et al. 2022

Adv Healthcare Materials

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Emerging biomanufacturing technologies have revolutionized the field of tissue engineering by offering unprecedented possibilities. Over the past few years, new opportunities arose by combining traditional and novel fabrication techniques, shaping the hybrid designs in biofabrication. One of the potential application fields is skin tissue engineering, in which a combination of traditional principles of wound dressing with advanced biofabrication methods could yield more efficient therapies. In this study, a hybrid design of fiber‐reinforced scaffolds combined with gel casting is developed and the efficiency for in vivo wound healing applications is assessed. For this purpose, 3D fiber meshes produced by melt electrowriting are selectively filled with photocrosslinkable gelatin hydrogel matrices loaded with different growth factor carrier microspheres. Additionally, the influence of the inclusion of inorganic bioactive glass particles within the composite fibrous mesh is evaluated. Qualitative evaluation of secondary wound healing criteria and histological analysis shows that hybrid scaffolds containing growth factors and bioactive glass enhances the healing process significantly, compared to the designs merely providing a fiber‐reinforced bioactive hydrogel matrix as the wound dressing. This study aims to explore a new application area for melt electrowriting as a powerful tool in fabricating hybrid therapeutic designs for skin tissue engineering.

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Section: Mechanical Properties and Swelling Behaviormentioning

confidence: 99%

3D Fiber Reinforced Hydrogel Scaffolds by Melt Electrowriting and Gel Casting as a Hybrid Design for Wound Healing

Afghah

Iyison

Nadernezhad

et al. 2022

Adv Healthcare Materials

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“…This scaffold had a large surface area with high permeability, which could be an asset for designing thymic blood micro-vessels. [171] Scaffold systems used in thymic construct show great promise as they provide robust structural support for TECs and act as a substitute for naturally occurring ECM. The ECM has shown to be able to mediate signaling pathways like RHO and ERK, needed for stem cell differentiation.…”

Section: Emerging Technologies In Thymus Regenerationmentioning

confidence: 99%

Recent Advancements in Regenerative Approaches for Thymus Rejuvenation

Sharma

Moroni

2021

Advanced Science

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The thymus plays a key role in adaptive immunity by generating a diverse population of T cells that defend the body against pathogens. Various factors from disease and toxic insults contribute to the degeneration of the thymus resulting in a fewer output of T cells. Consequently, the body is prone to a wide host of diseases and infections. In this review, first, the relevance of the thymus is discussed, followed by thymic embryological organogenesis and anatomy as well as the development and functionality of T cells. Attempts to regenerate the thymus include in vitro methods, such as forming thymic organoids aided by biofabrication techniques that are transplantable. Ex vivo methods that have shown promise in enhancing thymic regeneration are also discussed. Current regenerative technologies have not yet matched the complexity and functionality of the thymus. Therefore, emerging techniques that have shown promise and the challenges that lie ahead are explored.

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“…In the past decades, various ECM-inspired three-dimensional (3D) scaffolds have been investigated, including electrospun meshes, − patterned surfaces, ,,, and additive manufactured scaffolds, ,− with hydrogels being among the most promising ECM replacements. Hydrogels typically comprise macromolecular three-dimensional networks with a high water content.…”

Section: Introductionmentioning

confidence: 99%

Trends in Double Networks as Bioprintable and Injectable Hydrogel Scaffolds for Tissue Regeneration

Aldana

Houben

Moroni

et al. 2021

ACS Biomater. Sci. Eng.

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Fabrication of a self-assembled honeycomb nanofibrous scaffold to guide endothelial morphogenesis

Abstract: Fabrication of a self-assembled honeycomb nanofibrous scaffold to guide endothelial morphogenesis. Biofabrication, 12(4), [045001].

Cited by 14 publications

References 81 publications

3D Fiber Reinforced Hydrogel Scaffolds by Melt Electrowriting and Gel Casting as a Hybrid Design for Wound Healing

3D Fiber Reinforced Hydrogel Scaffolds by Melt Electrowriting and Gel Casting as a Hybrid Design for Wound Healing

Recent Advancements in Regenerative Approaches for Thymus Rejuvenation

Trends in Double Networks as Bioprintable and Injectable Hydrogel Scaffolds for Tissue Regeneration

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