Fabrication of amperometric sensor for glucose detection based on phosphotungstic acid–assisted PDPA/ZnO nanohybrid composite

Muthusankar, E.; Wabaidur, Saikh Mohammad; ALOthman, Zeid A.; Johan, Mohd Rafie; Ponnusamy, Vinoth Kumar; Dhanusuraman, Ragupathy

doi:10.1007/s11581-020-03740-0

Cited by 16 publications

(7 citation statements)

References 47 publications

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“…However, these materials have been ignored over the last few decades due to their lower electrical conductivity as compared to PANI. [13][14][15] In this context, modification of PDPA with a suitable filler enhances its useful properties, especially its mediocre conductivity. PDPA and its composites are used in bio-analyte sensing, fuel cells, electrochemical rechargeable batteries, solid-phase extraction of alcohols, and other applications.…”

Section: Introductionmentioning

confidence: 99%

High performance optical and electrical properties of zinc oxide reinforced poly(diphenylamine) nanocomposites for optoelectronic applications

Furhan

Ramesan

2022

Polymer Engineering & Sci

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Polymer nanocomposites with good optical, crystalline, morphological, thermal, dielectric, and electrical properties were synthesized using poly(diphenylamine) (PDPA) and zinc oxide (ZnO) nanoparticles. The redshift in the UV absorption edges of composites indicates that ZnO nanoparticles have been successfully incorporated into the PDPA matrix. The lowest optical bandgap energy and maximum refractive indices were observed in 7 wt% loadings. The narrowing of the avearge chain spacing detected by X-ray diffraction (XRD) proved that ZnO had an impact on the structure of PDPA. Scanning electron microscopy (SEM) images show homogeneous dispersion of spherically shaped ZnO nanoparticles at lower filler loadings. The glass transition temperature of the nanocomposites was greatly enhanced with the addition of nanoparticles analyzed by differential scanning calorimetry. The electrical and dielectric properties improved with temperature and nanoparticle loadings up to 7 wt%. The analysis of impedance spectra and the decreasing radius of semi-circular arcs in the Nyquist plot manifests the existence of temperature-dependent conductivity and relaxation phenomenon. The experimental values of DC conductivities were correlated with different theoretical conductivity models and the McCullough model was found to be the most promising one to explain the increased DC conductivity of the PDPA/ZnO nanocomposites.

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Section: Introductionmentioning

confidence: 99%

High performance optical and electrical properties of zinc oxide reinforced poly(diphenylamine) nanocomposites for optoelectronic applications

Furhan

Ramesan

2022

Polymer Engineering & Sci

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“…The selectivity of the sensor crucially depends on the ability of the receptor to bind only the target bioanalytes of interest, resulting in minimal noise from other coexisting molecules present in the biological sample. [30,[88][89][90] The selectivity and anti-interference can be simply assessed from a calibration curve for the coexisting interfering elements and equated to the targeted analyte calibration curve, as depicted in Figure 4C. Selectivity at this point is stated as the ratio of the output signal of the target analyte to the signal generated by interfering elements, at the same concentration of both samples.…”

Section: Selectivity and Anti-interferencementioning

confidence: 99%

“…The readout of the acquired signal typically requires some manipulation, which should preferably occur on the same unit as the detection. [23][24][25][26][27][28][29][30][31] A field-effect transistor (FET)-based biosensor is one type of electrical biosensor that attracted much attention in the past decade, owing to its suitability for devices used for point-of-care diagnostics, as well as in other fields such as, e.g., monitoring of environmental pollution, food quality, and pharmaceuticals. FET devices directly translate the analyte-receptor interaction into electrical signals.…”

Section: Introductionmentioning

confidence: 99%

A Road Map toward Field‐Effect Transistor Biosensor Technology for Early Stage Cancer Detection

Eswaran

Chokkiah²,

Pandit

et al. 2022

Small Methods

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ensure early detection, is the key to the survival of cancer patients. [1][2][3][4][5][6] Cancer biomarkers (encompassing metabolites, peptides/proteins, and nucleic acids-based markers) play a vital role in detecting cancers and monitoring their progression as well as in evaluating treatment effectiveness. Even minor changes in the levels of cancer biomarkers are very relevant for diagnostics. These minor changes need to be detected in complex biological samples, such as blood, saliva, urine, and/or other body fluids. [7][8][9][10][11][12] Hence, ultrasensitive and very specific diagnostic tools are required for the detection and quantification of such biomarkers. Conventional cancer detection methods such as computed tomography, cytological detection, magnetic resonance imaging, fluorescence imaging, immunohistochemistry, thermography, X-ray technique, radioimmunoassay, enzyme-linked immunosorbent assay (ELISA), and ultrasound method, typically encompass several stages, e.g., complex pretreatment processes, timeconsuming nucleic acid amplification or mass spectrometry analysis of protein biomarkers. In addition to being time-consuming, existing diagnostic tools are also typically expensive, and in some cases lack the required sensitivity and specificity, which limits their utility in clinical diagnostics. [13][14][15][16] Recent advancements in micro/nanoelectromechanical system (M/ NEMS) technology show their potential to overcome such drawbacks and have the possibility to fabricate a miniaturized device with highly selective and sensitive clinical diagnostic functions.

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“…[ 50,51 ] Currently, among the numerous cutting‐edge technological devices, especially in terms of glucose sensors, GCE has numerous attractive properties such as a low background current and convenient fabrication; therefore, it is an important electrode for nonenzymatic instruments. However, a drawback of this platform is its slow electron transfer; thus, it is necessary to modify the surface of the electrode by loading it with various catalyst nanomaterials such as noble and transition metal/metal oxides (e.g., Au, [ 52–54 ] Ag [ 55 ] /ZnO, [ 56,57 ] Cu 2 O, [ 58,59 ] NiO, [ 27,60 ] and Co 3 O 4 [ 61 ] ) and alloys/complexes (e.g., Cu 3 Pt, [ 62 ] Ni 5 P 4 , [ 50 ] and NiCo [ 63,64 ] ).…”

Section: Off‐body Sensors For Glucose Monitoringmentioning

confidence: 99%

Trending Technology of Glucose Monitoring during COVID‐19 Pandemic: Challenges in Personalized Healthcare

Phan

Hoang

et al. 2021

Adv Materials Technologies

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The COVID‐19 pandemic has continued to spread rapidly, and patients with diabetes are at risk of experiencing rapid progression and poor prognosis for appropriate treatment. Continuous glucose monitoring (CGM), which includes accurately tracking fluctuations in glucose levels without raising the risk of coronavirus exposure, becomes an important strategy for the self‐management of diabetes during this pandemic, efficiently contributing to the diabetes care and the fight against COVID‐19. Despite being less accurate than direct blood glucose monitoring, wearable noninvasive systems can encourage patient adherence by guaranteeing reliable results through high correlation between blood glucose levels and glucose concentrations in various other biofluids. This review highlights the trending technologies of glucose sensors during the ongoing COVID‐19 pandemic (2019–2020) that have been developed to make a significant contribution to effective management of diabetes and prevention of coronavirus spread, from off‐body systems to wearable on‐body CGM devices, including nanostructure and sensor performance in various biofluids. The advantages and disadvantages of various human biofluids for use in glucose sensors are also discussed. Furthermore, the challenges faced by wearable CGM sensors with respect to personalized healthcare during and after the pandemic are deliberated to emphasize the potential future directions of CGM devices for diabetes management.

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Fabrication of amperometric sensor for glucose detection based on phosphotungstic acid–assisted PDPA/ZnO nanohybrid composite

Cited by 16 publications

References 47 publications

High performance optical and electrical properties of zinc oxide reinforced poly(diphenylamine) nanocomposites for optoelectronic applications

High performance optical and electrical properties of zinc oxide reinforced poly(diphenylamine) nanocomposites for optoelectronic applications

A Road Map toward Field‐Effect Transistor Biosensor Technology for Early Stage Cancer Detection

Trending Technology of Glucose Monitoring during COVID‐19 Pandemic: Challenges in Personalized Healthcare

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