Fabrication of an AAO-based surface-enhanced Raman scattering substrate for the identification of levofloxacin in milk

Li, Nan; Han, Siqingaowa; Lin, Shuang; Sha, Xuanyu; Hasi, Wuliji

doi:10.1039/d1nj00642h

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…Self-Assembly of AuNPs@PNIPAM in the Au Nanobowl Templates: A monolayer of AuNPs was first formed via triphase transfer method, which is then self-assembled on the Au nanobowl template via dipcoating. [38] Typically, 1 mL of AuNPs dispersion was mixed with 2 µL of PNIPAM (10 mg mL −1 ) and incubated at 45 °C for 15 min, which was then centrifuged and redispersed in 0.1 mL of ethanol. 0.5 mL of CH 2 Cl 2 and 0.9 mL of H 2 O were added in this dispersion, followed by vigorous shaking to transfer the AuNPs to the interface between water and CH 2 Cl 2 .…”

Section: Methodsmentioning

confidence: 99%

Dynamic and Reversible Tuning of Particle‐in‐Bowl Shaped Plasmonic Resonators for Switchable Surface Enhanced Raman Scattering

Deng

Xiang

Wang

et al. 2021

Adv Materials Inter

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water splitting, [14] and biomedical diagnosis. [15] Among many of these designs, nanoparticle-in-void structure appears more attractive as it has a uniform hemispherical gap between the nanoparticle and the inner wall of the void, promising a much higher SERS enhancement and uniformity. [16,17] However, such a nanoscale hemispherical configuration with good uniformity poses great challenge to the traditional fabrication methods. Although drop-casting of nanoparticles and thermal dewetting of the metal films in ordered porous template can produce particles in the void, their morphology is not welldefined with lots of local defects. [18][19][20][21][22][23] The gap formed via electrochemical growth appears more uniform and controllable, [24] but the gap between the particle and the inner wall of nanobowl is fully filled, which has to resort to overcoating of another Ag films to boost its SERS performance. [25] Moreover, none of these structures are dynamically tunable, making it much less versatile.Ideally, the geometry of single Au nanoparticle in bowl (Au NPiB) with a proper space in between is desired to support plasmonic hot spots for SERS, which requires 1) matchable sizes between the Au nanovoids and the Au nanoparticles (AuNPs); 2) properly functionalized surfaces that hinder the aggregation of AuNPs during the assembly process; 3) monolayer of AuNPs to avoid random stacking. It is nontrivial to meet all these three requirements although it is quite easy to achieve one or two via conventional self-assembly or colloidal lithography.Here, we employ anodic aluminum oxide (AAO) as the nanobowl template, which are sputter-coated with Au films to generate Au nanobowl arrays. The size of these nanobowls is ≈80 nm which is slightly larger than the AuNPs (≈60 nm) used for self-assembly (Requirement 1). These AuNPs are coated with poly(N-isopropylamide) (PNIPAM), which not only provides steric hindrance against aggregation but also endows the thermal tunability of the plasmonic system (Requirement 2). The Au@PNIPAM NP monolayer assembled at liquidliquid interface is transferred to the Au nanobowl arrays via dip-coating so that each void of nanobowl is filled with just one Au@PNIPAM NP (Requirement 3). As the gap between the AuNP and the Au bowl is filled with PNIPAM, their separation can be reversibly tuned by simply controlling the Plasmonic nanoresonators made of particle-in-void have been considered as superior plasmonic cavities for surface enhanced Raman scattering (SERS). However, controlled fabrication of such plasmonic system and its dynamic tuning pose great challenges to traditional fabrication methods. Here, a capillary-driven self-assembly is proposed to form gold nanoparticles in bowls (Au NPiBs), which have a nm-gap filled with temperature-responsive polymers (poly(N-isopropylacrylamide)). As such, the plasmonic resonances of the Au NPiB nanostructures can be dynamically and reversibly tuned with the change of temperature due to the thermally induced expansion and contraction of the polymers. The SERS e...

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Section: Methodsmentioning

confidence: 99%

Dynamic and Reversible Tuning of Particle‐in‐Bowl Shaped Plasmonic Resonators for Switchable Surface Enhanced Raman Scattering

Deng

Xiang

Wang

et al. 2021

Adv Materials Inter

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“…For these 0D nanoarray substrates based on AAO templates, a simple approach is to embed metal nanoparticles into nanochannels of AAO templates, which can avoid random aggregation of these nanoparticles during SERS testing. 118 Furthermore, the 0D nanoarray substrates based on AAO templates display stable and repeatable SERS signals when used to trap molecules because of the uniform distribution of nanopores of the AAO templates. 75 The tunable nanopore structural parameters, such as the position, size, and shape, of AAO templates combine active materials synthesized by different technologies and also make SERS substrates prepared by AAO-template-assisted approaches have multiple hot spots, leading to largely enhanced SERS signals.…”

Section: Substratesmentioning

confidence: 99%

“…Taking advantage of the pore-confinement effect and structural tunability of AAO templates, the distribution, size, spacing, and morphology of 0D nanoarray structures, prepared from AAO templates, can be meticulously controlled to optimize their performance as SERS substrates. For these 0D nanoarray substrates based on AAO templates, a simple approach is to embed metal nanoparticles into nanochannels of AAO templates, which can avoid random aggregation of these nanoparticles during SERS testing . Furthermore, the 0D nanoarray substrates based on AAO templates display stable and repeatable SERS signals when used to trap molecules because of the uniform distribution of nanopores of the AAO templates .…”

Section: Structure Engineering Of Aao-based Sers Substratesmentioning

confidence: 99%

Ordered Anodic Aluminum Oxide-Based Nanostructures for Surface-Enhanced Raman Scattering: A Review

Wu,

Sha,

et al. 2024

ACS Appl. Nano Mater.

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As a promising spectroscopic technique, surface enhanced raman spectroscopy (SERS) has been intensively used in bio/chemical sensing, attributing to its unique advantages of ultrasensitive and accurate detection of trace amounts of analytes, high specific fingerprint-like features, fast response, and noninvasive sensing. The robustness and consistency of SERS signals in practical analytical applications highly rely on the composition, structural morphology, and uniformity of SERS substrates. These factors play a pivotal role in determining the intensity and reproducibility of the detected signals. SERS substrates based on ordered nanostructures that are fabricated from anodic aluminum oxide (AAO)-templateassisted approaches are of significant interest due to their cost effectiveness, scalability, precise structural control, and exceptionally ordered features. In this review, recent progress in SERS substrates with high sensitivity and reproducibility prepared from AAO templates is highlighted. We emphasize the optimization strategies toward achieving efficient SERS-active substrates by fine-tuning the size, composition, and morphology of AAO-derived ordered nanostructures. Furthermore, we delve into the discussion of flexible and smart SERS substrates, while also exploring key aspects pertinent to further amplifying SERS signals. Overall, this review aims to offer insights into the future integration of the AAO templates technique with SERS, providing crucial perspectives for forthcoming research in this field.

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“…According to different experimental methods, SERS can enhance the signal by 10 4 -10 15 times compared with ordinary Raman spectroscopy [21], which greatly improves the detection sensitivity and can reach the level of single virus [22]. Based on its advantages of high sensitivity, speed, nondestructive and good biocompatibility, it has been widely used in many fields such as biomedicine, food and environmental safety [23,24]. The Raman nanospheres (RNPs) used in this study are a new type of nanomaterials with core-shell structure formed by the fusion of a variety of metals, small molecular substances, polymers, etc.…”

Section: Introductionmentioning

confidence: 99%

Combined detection of SARS-CoV-2 neutralizing antibodies and specific IgG in plasma based on SERS magnetic sensor

Song,

Wang,

Jiao

et al. 2023

Nanotechnology

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In this study, a surface-enhanced Raman spectroscopy (SERS) magnetic sensor is established based on SERS principle and magnetic separation technology, and a highly sensitive, simple and fast method for quantitative detection of neutralizing antibodies (nABs) and specific IgG of SARS-CoV-2 in plasma is established combined with immunoassay. Two kinds of Raman nanospheres (RNPs) with different characteristic Raman shifts are used as signal sources and coupled to ACE2 and anti-IgG (FC) antibodies respectively, and magnetic beads are coupled to RBD. The competitive relationship between ACE2 and nABs, the binding relationship between specific IgG and anti-IgG (FC) antibodies are determined. The results show that the concentrations of nABs and specific IgG in the range of 10–2000 ng ml−1 are well correlated with SERS response intensity, and the recoveries are both between 90%–110%, with good precision. Bilirubin and common anticoagulants have no interference on the detection results. This method is accurate, reliable, sensitive and does not require complex pre-treatment, and is expected to be used for simultaneous detection of nABs and specific IgG in plasma of SARS-CoV-2. It has guiding significance for the development and evaluation of vaccines and the formulation of individualized vaccination schedule.

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Fabrication of an AAO-based surface-enhanced Raman scattering substrate for the identification of levofloxacin in milk

Abstract: In the process of preparing a solid surface-enhanced Raman scattering (SERS) substrate, there is a need to devise a simple and efficient method that will ensure an even distribution of...

Cited by 11 publications

References 27 publications

Dynamic and Reversible Tuning of Particle‐in‐Bowl Shaped Plasmonic Resonators for Switchable Surface Enhanced Raman Scattering

Dynamic and Reversible Tuning of Particle‐in‐Bowl Shaped Plasmonic Resonators for Switchable Surface Enhanced Raman Scattering

Ordered Anodic Aluminum Oxide-Based Nanostructures for Surface-Enhanced Raman Scattering: A Review

Combined detection of SARS-CoV-2 neutralizing antibodies and specific IgG in plasma based on SERS magnetic sensor

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