Fabrication of an align-random distinct, heterogeneous nanofiber mat endowed with bifunctional properties for engineered 3D cardiac anisotropy

Eom, Seongsu; Park, Sang Min; Hwang, Dong Soo; Kim, Hyung Woo; Jang, Jinah; Kim, Dong Sung

doi:10.1016/j.compositesb.2021.109336

Cited by 18 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The original goal of this study was to examine the nanofibrous scaffolds in an in vitro environment. Thus, the assessment of scaffold biodegradability is one of the essential aspects to be considered in this research 54,55 …”

Section: Resultsmentioning

confidence: 99%

“…Thus, the assessment of scaffold biodegradability is one of the essential aspects to be considered in this research. 54,55 The morphology of the Alg0.5GO/PCL and Alg1GO/PCL samples was studied after 7 and 14 days of soaking in PBS solution to evaluate the stability of the GO-incorporated samples. The obtained SEM images of the sample surfaces after soaking and the weight loss diagram are depicted in Fig.…”

Section: Biodegradabilitymentioning

confidence: 99%

See 1 more Smart Citation

Tri‐layered alginate/poly(𝜀‐caprolactone) electrospun scaffold for cardiac tissue engineering

Karimi

Aghdam

Ebrahimi

et al. 2022

Polymer International

View full text Add to dashboard Cite

Novel tri‐layered electrospun alginate–graphene oxide (GO)/poly(ε‐caprolactone) (PCL) conductive scaffolds were fabricated with a sequential electrospinning method for the first time, in which the middle PCL layer acts as a mechanical support of the scaffold. The top and bottom alginate–GO nanofibrous layers provide cell viability and attachment, and also electroconductivity for the scaffold. The fabrication of this nanofibrous scaffold aims to simulate cardiac extracellular matrix. Scanning electron microscopy and infrared spectroscopy were used to characterize the nanofibrous scaffolds, confirming the presence of GO in nanofibers and also crosslinking reaction of the alginate nanofibrous layer. The electroconductivity of the tri‐layered electrospun scaffolds reached 7.29 ± 0.91 μS with the incorporation of 1 wt% GO into the top and bottom alginate nanofibrous layers. The ultimate tensile strength and Young’s modulus of the alginate–0.5 wt% GO/PCL scaffold reached 22.46 ± 0.07 and 4.35 ± 0.56 MPa, respectively. The biocompatibility of the nanofibrous scaffolds was evaluated using cardiac progenitor cells. The results showed that the presence of GO accelerated the degradation of the scaffolds in phosphate‐buffered saline solution. The cell studies revealed that GO incorporation into alginate nanofibers on the surface of the tri‐layer scaffolds could enhance cell viability, adhesion and proliferation. Overall, the tri‐layered electroconductive alginate–PCL nanofibrous scaffolds could be considered as potential candidates for cardiac tissue regeneration. © 2022 Society of Industrial Chemistry.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Biodegradabilitymentioning

confidence: 99%

Tri‐layered alginate/poly(𝜀‐caprolactone) electrospun scaffold for cardiac tissue engineering

Karimi

Aghdam

Ebrahimi

et al. 2022

Polymer International

View full text Add to dashboard Cite

show abstract

“…On the other hand, Eom et al suggested a novel stacking method without using the rigid frame (Figure 7a(iii)). [97] By developing a hollow patterned electrolyteassisted electrospinning process, they could construct an alignrandom distinct, heterogeneous 2D NFM in a single fabrication step. The fabricated NFM comprised aligned NFs in the core region and random NFs, which provided hand-maneuverable mechanical properties, at the peripherial region.…”

Section: Stackingmentioning

confidence: 99%

Recent Progress in Fabrication of Electrospun Nanofiber Membranes for Developing Physiological In Vitro Organ/Tissue Models

Kim,

Youn,

Lee

et al. 2023

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

Nanofiber membranes (NFMs), which have an extracellular matrix (ECM)‐mimicking structure and unique physical properties, have garnered great attention as biomimetic materials for developing physiologically relevant in vitro organ/tissue models. Recent progress in NFM fabrication techniques immensely contributed to the development of NFM‐based cell culture platforms for constructing physiological organ/tissue models. However, despite the significance of the NFM fabrication technique, an in‐depth discussion of the fabrication technique and its future aspect was insufficient. This review provides an overview of the current state‐of‐the‐art of NFM fabrication techniques from electrospinning techniques to post‐processing techniques for the fabrication of various types of NFM‐based cell culture platforms. Moreover, the advantages of the NFM‐based culture platforms in the construction of organ/tissue models are discussed especially for tissue barrier models, spheroids/organoids, and biomimetic organ/tissue constructs. Finally, the review concludes with perspectives on challenges and future directions for fabrication and utilization of NFMs.This article is protected by copyright. All rights reserved

show abstract

“…For example, researchers prepared electrospun PCL nanofiber mats with aligned fibers at the central part and random fibers at the periphery. 186 A 3D nanofiber scaffold was obtained by sequentially stacking three layers of nanofiber mats with different orientation directions at the central part. The scaffold had good mechanical stability and was able to promote the alignment, adhesion, and maturation of cardiomyocytes along the orientation direction of the nanofibers to form a specific layer of cells for initial endothelialization.…”

Section: Cardiac Tissue Regenerationmentioning

confidence: 99%

Electrospun nanofibers for manipulating soft tissue regeneration

et al. 2022

View full text Add to dashboard Cite

show abstract

Fabrication of an align-random distinct, heterogeneous nanofiber mat endowed with bifunctional properties for engineered 3D cardiac anisotropy

Cited by 18 publications

References 48 publications

Tri‐layered alginate/poly(𝜀‐caprolactone) electrospun scaffold for cardiac tissue engineering

Tri‐layered alginate/poly(𝜀‐caprolactone) electrospun scaffold for cardiac tissue engineering

Recent Progress in Fabrication of Electrospun Nanofiber Membranes for Developing Physiological In Vitro Organ/Tissue Models

Electrospun nanofibers for manipulating soft tissue regeneration

Contact Info

Product

Resources

About