Fabrication of antibacterial polydopamine-carboxymethyl cellulose-Ag nanoparticle hydrogel coating for urinary catheters

Abstract

Urinary tract infections caused by catheter insertion are prevalent in hospital clinics, which can induce serious complications such as bacteriuria and sepsis, and even lead to patient death. The disposable catheters currently used in clinical practice suffer from poor biocompatibility and high infection rate. In this paper, we developed a polydopamine (PDA)-carboxymethylcellulose (CMC)-Ag nanoparticles (AgNPs) coating with both good antibacterial and anti-adhesion properties to bacteria on the surfaces of a disposable medical latex catheter by a simple dipping method. The antibacterial efficiency of the coated catheters against Gram-negative E. coli and Gram-positive S. aureus bacteria was evaluated with both inhibition zone tests and fluorescence microscopy. Compared with the untreated catheter, the PDA-CMC-AgNPs coated catheters showed both good antibacterial and anti-adhesion properties to bacteria, which inhibited the adhesion of live bacteria and dead bacteria by 99.0% and 86.6%, respectively. This novel PDA-CMC-AgNPs composite hydrogel coating has great potential in applications in catheters and other biomedical devices to reduce infections.

An Overview of Biofilm-Associated Infections and the Role of Phytochemicals and Nanomaterials in Their Control and Prevention

“…In such studies, methods allowing for the enhancement of biocompatibility must also be considered. Valuable advancements are associated with improving the antiadhesive and antibiofilm properties of urinary catheters coated with nanoparticles [ 121 , 122 , 123 , 124 ]. Moreover, incorporating metal and metal oxide nanoparticles into polymeric membranes is regarded as a natural approach for creating distinctive wound bandages with antibacterial and antibiofilm properties.…”

Recent Advances in Combating Bacterial Infections by Using Hybrid Nano-Systems

“…Recently, inherently antimicrobial nano-systems have been used to modify bone implants, stents, and catheters in order to prevent implant-associated infections. EVA/BS@SN ureteral J-shaped stents E. coli [186] SF/CS/Cu coating for cardiovascular stents N/A [187] PVP-AgNPs coated on silicone hydrogel E. coli [188] Nanomaterial-Modified Catheters Ag/Cu-coated catheters MRSA [189] ACPs@AgNP-coated catheter Drug resistant S. aureus [190] AgPEI NP-coated catheter Candida species [191] PDA-CMC-AgNP-coated urinary catheter E. coli, S. aureus [192] ZnO coated central venous catheter P. aeruginosa, E. coli, S. aureus [193] ZnO NP-grafted silicone catheter P. aeruginosa [194] AgNP-coated mini catheters P. aeruginosa [195] GO/CU coating C. parapsilosis [196] Ag/TiOx-PDMS nanofilm P. aeruginosa, E. coli, S. aureus [197] Nanomaterial Modified Tissue Scaffolds AgNP-silk fibroin scaffold E. coli, S. aureus [177] PCL/AgNP-coated tissue scaffold E. coli [198] Chitosan-CMC-FZO@Hap scaffold E. coli, S. paratyphi, S. aureus, & L. monocytogenes [199] Hap/AgNP-loaded cellulose scaffold E. coli, S. aureus [200] CuFe 2 O 4 -MXene/PLLA tracheal scaffold S. aureus, P. aeruginosa [201] Ag/MBG scaffold E. coli, S. aureus [202] LgNP/PCL nanofiber scaffold S. aureus [203] Antimicrobial properties and biocompatibility are crucial factors in the long-term success of titanium bone implants. Yuan et al [178] developed a nano-system for bone implants with inherently antimicrobial activity and high biocompatibility by using titanium dioxide nanotubes (TNTs or TiO 2 -NTs) loaded with AgNPs and coated with chitosan (CHI) and dialdehyde alginate (ADA) using a layer by layer (LBL) technique.…”