Fabrication of Ascorbic Acid Biosensor Based on Coupling Polyethylene Glycol Modified Silk Fibroin Membrane onto Glassy Carbon Electrode

Ratanasongtham, Pacharawan; Shank, Lalida; Jakmunee, Jaroon; Watanesk, Ruangsri; Watanesk, Surasak

doi:10.4028/www.scientific.net/amm.835.63

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…[6][7][8][9][10] Typical biocompatible materials for implantable sensors are, for example, gold and platinum as well as polymers such as polyethylene glycol (PEG), polylactide acid (PLA), poly (vinyl alcohol) (PVA), chitosan, and fibroin. [11][12][13][14][15][16][17][18][19] Being at the same time biodegradable, however, further limits the materials in use. Nonetheless, only very few are considered bioabsorbable and materials further offering suitable properties for application as sensors in all due respects are still highly sought after.…”

Section: Introductionmentioning

confidence: 99%

Transient magnesium‐based thin‐film temperature sensor on a flexible, bioabsorbable substrate for future medical applications

Janus,

Achtsnicht,

Drinic

et al. 2023

Applied Research

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In this work, the bioabsorbable materials, namely fibroin, polylactide acid (PLA), magnesium, and magnesium oxide are investigated for their application as transient, resistive temperature detectors (RTD). For this purpose, a thin‐film magnesium‐based meander‐like electrode is deposited onto a flexible, bioabsorbable substrate (fibroin or PLA) and encapsulated (passivated) by additional magnesium oxide layers on top and below the magnesium‐based electrode. The morphology of different layered RTDs is analyzed by scanning electron microscopy. The sensor performance and lifetime of the RTD is characterized both under ambient atmospheric conditions between 30°C and 43°C, and wet tissue‐like conditions with a constant temperature regime of 37°C. The latter triggers the degradation process of the magnesium‐based layers. The 3‐layers RTDs on a PLA substrate could achieve a lifetime of 8.5 h. These sensors also show the best sensor performance under ambient atmospheric conditions with a mean sensitivity of 0.48 Ω/°C ± 0.01 Ω/°C.

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Section: Introductionmentioning

confidence: 99%

Transient magnesium‐based thin‐film temperature sensor on a flexible, bioabsorbable substrate for future medical applications

Janus,

Achtsnicht,

Drinic

et al. 2023

Applied Research

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“…[27][28][29][30][31] Fibroin has been also suggested as a biocompatible interface to immobilize enzymes on a glassy carbon electrode to detect ascorbic acid or organophosphates and carbamates. [32,33] Biocompatible electronics have been transferred to various surfaces such as teeth, eggs, or feline brain due to the adjustable water solubility of the fibroin membrane. [34][35][36] Our group recently introduced fibroin as a biocompatible and biodegradable substrate for an amperometric glucose biosensor.…”

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confidence: 99%

Influence of Fibroin Membrane Composition and Curing Parameters on the Performance of a Biodegradable Enzymatic Biosensor Manufactured from Silicon‐Free Carbon

Janus

Achtsnicht

Tempel

et al. 2023

Physica Status Solidi (a)

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Herein, fibroin, polylactide (PLA), and carbon are investigated for their suitability as biocompatible and biodegradable materials for amperometric biosensors. For this purpose, screen‐printed carbon electrodes on the biodegradable substrates fibroin and PLA are modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. The influence of different curing parameters of the carbon electrodes on the resulting biosensor characteristics is studied. The morphology of the electrodes is investigated by scanning electron microscopy, and the biosensor performance is examined by amperometric measurements of glucose (0.5–10 mM) in phosphate buffer solution, pH 7.4, at an applied potential of 1.2 V versus a Ag/AgCl reference electrode. Instead of Ecoflex, fibroin, PLA, and wound adhesive are tested as alternative encapsulation compounds: a series of swelling tests with different fibroin compositions, PLA, and Ecoflex has been performed before characterizing the most promising candidates by chronoamperometry. Therefore, the carbon electrodes are completely covered with the particular encapsulation material. Chronoamperometric measurements with H2O2 concentrations between 0.5 and 10 mM enable studying the leakage current behavior.

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Nano‐bio‐engineered silk matrix based devices for molecular bioanalysis

Sammi

Divya

Mahapatra

et al. 2022

Biotech & Bioengineering

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Silk is a fibrous protein, has been a part of human lives for centuries, and was used as suture and textile material. Silk is mainly produced by the members of certain arthropods such as spiders, butterflies, mites, and moths. However, recent technological advances have revolutionized silk as a biomaterial for various applications ranging from heat sensors to robust fibers. The biocompatibility, mechanical resilience, and biodegradability of the material make it a suitable candidate for biomaterials. Silk can also be easily converted into several morphological forms, including fibers, films, sponges, and hydrogels. Provided these abilities, silk have received excellent traction from scientists worldwide for various developments, one of them being its use as a bio-sensor. The diversity of silk materials offers various options, giving scientists the freedom to choose from and personalize them as per their needs. In this review, we foremost look upon the composition, production, properties, and various morphologies of silk. The numerous applications of silk and its derivatives for fabricating biosensors to detect small molecules, macromolecules, and cells have been explored comprehensively. Also, the data from various globally developed sensors using silk have been described into organized tables for each category of molecules, along with their important analytical details.

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Fabrication of Ascorbic Acid Biosensor Based on Coupling Polyethylene Glycol Modified Silk Fibroin Membrane onto Glassy Carbon Electrode

Cited by 3 publications

References 13 publications

Transient magnesium‐based thin‐film temperature sensor on a flexible, bioabsorbable substrate for future medical applications

Transient magnesium‐based thin‐film temperature sensor on a flexible, bioabsorbable substrate for future medical applications

Influence of Fibroin Membrane Composition and Curing Parameters on the Performance of a Biodegradable Enzymatic Biosensor Manufactured from Silicon‐Free Carbon

Nano‐bio‐engineered silk matrix based devices for molecular bioanalysis

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