Fabrication of biodegradable foams for deep tissue negative pressure treatments

Abstract

Devices for negative pressure wound therapy (NPWT) rely on compressible foams operating at the tissue-device interface. Clinically used foams are nonabsorbable and if used on deep wounds or left in place for an extended period of time, excessive cell ingrowth and formation of granulation tissue into the foam may require a surgical procedure to remove the foam. Foams with fast degradation and with low immunogenicity and fibrotic response are required. Foams composed of combinations of poly(lactide-co-glycolide) (PLGA), poly(lactide-co-caprolactone) (PLCL), and polycaprolactone (PCL) were created by combined salt leaching and solvent displacement protocols. In vitro and in vivo degradation studies and mechanical properties of foams were evaluated and compared to clinically used poly(vinyl alcohol) (PVA) foam and PCL foams. Foams composed of PLGA (50:50 lactide:glycolide) of low molecular weight blended with PCL maintained mechanical properties and degraded significantly after 21 days of subcutaneous implantation in rats. The most ideal formulations for use in NPWT were identified as copolymeric PLGA (M 3000 Da) at a lactide:glycolide ratio of 50:50 combined with PCL at either a 75:25 or 50:50 ratio, and copolymeric PLGA (M 7500 Da) at a lactide:glycolide ratio of 50:50 combined with PCL at a 50:50 ratio. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1998-2007, 2018.

Hydrogel‐coated polyurethane/urea shape memory polymer foams

“…We prepared SMP foams using the salt template/particulate leaching approach described by Mather and others . Recently, Warner and Wagner used the salt templating approach to prepare biodegradable foam biomaterials for negative pressure wound therapy applications .…”

Microfluidics Mediated Production of Foams for Biomedical Applications

“…Materials used in this context are in most cases of polymeric origin [30]. In recent years, biodegradable compressible foams based on a mixture of poly(lactic-co-glycolic Acid) (PLGA), polycaprolactone (PCL), and poly(L-lactide-co--caprolactone) (PLCL) for negative pressure wound therapy have been fabricated [55]. Density graded polymer foams have also been explored for interfacial tissue engineering and showed interesting mechanical behavior [141].…”

“…Scaffolds are obtained through solidification of these preformed liquid foams [36]. The ability to control biomaterial physico-chemical properties down to micrometer and nanometer scales [47] has opened new routes in biomedicine for cell transplantation [48], drug release [9,49], health monitoring [50][51][52], diagnostics [53], and therapeutic treatments in situ [54,55].…”

Fabrication of Highly Interconnected Poly(ε-caprolactone)/cellulose Nanofiber Composite Foams by Microcellular Foaming and Leaching Processes

“…The study of biodegradable recycled plastics is the development trend of green sustainable materials. With its unique interconnectivity and a three-dimensional (3D) skeleton structure, open-cell polymer foam materials are widely used in sound-absorbing materials, petroleum absorbent materials, wastewater or sewage treatment materials, optical materials, biomedical materials, conductive materials, and filter membrane materials . Nanocomposite foams provide new opportunities to produce tissue engineering, cancer treatment, medical imaging, dental applications, drug delivery, and other modern medicine products. , …”