Fabrication of biodegradable nano-sized β-TCP/Mg composite by a novel melt shearing technology

Liu, Debao; Zuo, Yubo; Wei, Meng; Chen, Mingfang; Fan, Z.

doi:10.1016/j.msec.2012.03.017

Cited by 51 publications

(23 citation statements)

References 25 publications

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“…Mg alloys and Mg‐based composites have been explored to potentially address these problems. Previously, Mg/β‐tricalcium phosphate (β‐TCP) composites showed improvement of mechanical properties, when they were prepared using a powder metallurgy process coupled with spark plasma sintering (SPS) .…”

Section: Introductionmentioning

confidence: 99%

“…3,5,6 Nevertheless, the rapid degradation rate of Mg and associated early deterioration of mechanical properties are still problematic for orthopedic implant and device applications. 7,8 Mg alloys [9][10][11][12] and Mg-based composites [13][14][15][16][17][18][19][20] have been explored to potentially address these problems. Previously, Mg/β-tricalcium phosphate (β-TCP) composites showed improvement of mechanical properties, when they were prepared using a powder metallurgy process coupled with spark plasma sintering (SPS).…”

Section: Introductionmentioning

confidence: 99%

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Degradation behaviors and cytocompatibility of Mg/β‐tricalcium phosphate composites produced by spark plasma sintering

et al. 2019

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Magnesium (Mg)‐based materials have shown great potentials for bioresorbable implant applications. Previous studies showed that Mg with 10 and 20 vol % β‐tricalcium phosphate (β‐TCP) composites produced by spark plasma sintering, improved mechanical properties when compared with pure Mg. The objectives of this study were to evaluate the degradation behaviors of Mg/10% β‐TCP and Mg/20% β‐TCP composites in revised stimulated body fluid (rSBF), and to determine their cytocompatibility with bone marrow derived mesenchymal stem cells (BMSCs) using the direct culture method. During the 11 days of immersion in rSBF, Mg/β‐TCP composites showed different degradation behaviors at different immersion periods, that is, the initial stage (0–1 hr), the mid‐term stage (1 hr to 2 days), and the long‐term stage (2−11 days). The counter effects of mass loss due to microgalvanic corrosion and mass gain due to deposition of Ca‐P containing layers resulted in slower Mg2+ ion release for Mg/20% β‐TCP than Mg/10% β‐TCP in the mid‐term, but eventually 16% mass loss for Mg/20% β‐TCP and 10% mass loss for Mg/10% β‐TCP after 11 days of immersion. The in vitro studies with BMSCs showed the highest cell adhesion density (i.e., 68% of seeding density) on the plate surrounding the Mg/10% β‐TCP sample, that is, under the indirect contact condition of direct culture. The β‐TCP showed a positive effect on direct adhesion of BMSCs on the surface of Mg/β‐TCP composites. This study elucidated the degradation behaviors and the cytocompatibility of Mg/β‐TCP composites in vitro; and, further studies on Mg/ceramic composites are needed to determine their potential for clinical applications. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2238–2253, 2019.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Degradation behaviors and cytocompatibility of Mg/β‐tricalcium phosphate composites produced by spark plasma sintering

et al. 2019

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“…According to the relevant studies [27,28], Mg-5Sn mainly consists of primary α-Mg and eutectic Mg 2 Sn phases and the sole secondary phase in Mg-Sn system is the Mg 2 Sn phase [25]. As for the HA/Mg and β-TCP/Mg composites, no other reaction phases were detected between the HA or β-TCP and Mg alloys, either [15,29].…”

Section: Microstructuresmentioning

confidence: 99%

“…A promising improving method is to fabricate Mg alloy matrix composite, which is reinforced by bioceramic of natural human bone compositions such as hydroxylapatite (HA) and β-tricalcium phosphate (β-TCP) [11,12]. Recent investigations have demonstrated that these composites had excellent biocompatibility, bioactivity, osteoconduction characteristics, adjustable mechanical properties (Young's modulus and tensile strength) and biological properties [11,[13][14][15]. Further researches have shown that biphasic calcium phosphate ceramic (HA + β-TCP) is considered to have better resorbability or bioactivity than pure HA or β-TCP, and its bioactivity can be controlled by adjusting the ratio of HA to β-TCP [16,17].…”

Section: Introductionmentioning

confidence: 99%

Structure, mechanical property and corrosion behaviors of (HA + β-TCP)/Mg–5Sn composite with interpenetrating networks

Wang

Xie

et al. 2015

Materials Science and Engineering: C

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“…[5][6][7] To a certain extent the degradation rate of Mg in body fluid for bone implant is high. [1,[12][13][14] In spite of these improvements, there are some limitations in order to apply in clinical. [1,[12][13][14] In spite of these improvements, there are some limitations in order to apply in clinical.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Mg/Nano‐HA Composites by Spark Plasma Sintering Method and Evaluation of Different Milling Time Effects on Their Microhardness, Corrosion Resistance, and Biocompatibility

et al. 2016

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Herein, Mg/nano-HA composites (10 wt% nano-HA) are prepared by spark plasma sintering (SPS) technique. Indeed, hydroxyapatite (HA) is used as reinforcement material in order to maintain biocompatibility and bioactivity. The influence of high energy ball milling time are considered by different methods. The study finds that an appropriate time (5 h) during high energy ball milling process effectively can eliminate the prior particle boundary (PPB). Furthermore, the Mg/nano-HA composites milled for 5 h has appropriate microhardness, stable corrosion resistant, and excellent biocompatibility, which can act as a potential candidate for orthopedic implants.

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Fabrication of biodegradable nano-sized β-TCP/Mg composite by a novel melt shearing technology

Cited by 51 publications

References 25 publications

Degradation behaviors and cytocompatibility of Mg/β‐tricalcium phosphate composites produced by spark plasma sintering

Degradation behaviors and cytocompatibility of Mg/β‐tricalcium phosphate composites produced by spark plasma sintering

Structure, mechanical property and corrosion behaviors of (HA + β-TCP)/Mg–5Sn composite with interpenetrating networks

Preparation of Mg/Nano‐HA Composites by Spark Plasma Sintering Method and Evaluation of Different Milling Time Effects on Their Microhardness, Corrosion Resistance, and Biocompatibility

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