Fabrication of biodegradable Zn-Al-Mg alloy: Mechanical properties, corrosion behavior, cytotoxicity and antibacterial activities

Bakhsheshi‐Rad, Hamid Reza; Hamzah, Esah; Low, H. T.; Kasiri‐Asgarani, Masoud; Farahany, Saeed; Akbari, Ebrahim; Cho, M.H.

doi:10.1016/j.msec.2016.11.138

Cited by 154 publications

(91 citation statements)

References 18 publications

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“…The addition of 0.1-0.5 wt % Mg to the Zn-Al system decreased the corrosion rate with increasing Mg content, after 720 h of immersion in simulated body fluid (SBF) solution. The cytotoxicity results demonstrated acceptable biocompatibility of the Zn-0.5Al-0.5Mg alloy, with superior antibacterial activity relative to the other alloys [51].…”

Section: Zinc Alloysmentioning

confidence: 91%

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

Levy

Goldman

Aghion

2017

Metals

238

124

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Abstract:In the last decade, iron and magnesium, both pure and alloyed, have been extensively studied as potential biodegradable metals for medical applications. However, broad experience with these material systems has uncovered critical limitations in terms of their suitability for clinical applications. Recently, zinc and zinc-based alloys have been proposed as new additions to the list of degradable metals and as promising alternatives to magnesium and iron. The main byproduct of zinc metal corrosion, Zn 2+ , is highly regulated within physiological systems and plays a critical role in numerous fundamental cellular processes. Zn 2+ released from an implant may suppress harmful smooth muscle cells and restenosis in arteries, while stimulating beneficial osteogenesis in bone. An important limitation of pure zinc as a potential biodegradable structural support, however, lies in its low strength (σ UTS~3 0 MPa) and plasticity (ε < 0.25%) that are insufficient for most medical device applications. Developing high strength and ductility zinc with sufficient hardness, while retaining its biocompatibility, is one of the main goals of metallurgical engineering. This paper will review and compare the biocompatibility, corrosion behavior and mechanical properties of pure zinc, as well as currently researched zinc alloys.

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Section: Zinc Alloysmentioning

confidence: 91%

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

Levy

Goldman

Aghion

2017

Metals

238

124

View full text Add to dashboard Cite

show abstract

“…Again, using Zn-Mg as a base for the ternary alloy makes sense, since this binary combination is the most studied owing to its expected good biocompatibility. Reports on Mg additions to binary alloys of Zn-Cu [117] and Zn-Al [118] are also available.…”

Section: Ternary Alloysmentioning

confidence: 99%

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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Zinc has been identified as one of the most promising biodegradable metals along with magnesium and iron. Zinc appears to address some of the core engineering problems associated with magnesium and iron when applied to biomedical implant applications; hence the increase in the amount of research investigations on the metal in the last few years. In this review, the current state-of-the-art on biodegradable Zn, including recent developments, current opportunities and future directions of research are discussed. The discussions are presented with a specific focus on reviewing the relationships that exist between mechanical properties, biodegradability, and biocompatibility of zinc with alloying and fabrication techniques. This work hopes to guide future studies on biodegradable Zn that will help in advancing this field of research. Statement of Significance (i) The review offers an up-to-date and comprehensive review of the influence of alloying and fabrication technique on mechanical properties, biodegradability and biocompatibility of Zn; (ii) the work cites the most relevant biodegradable Zn fabrication processes including additive manufacturing techniques; (iii) the review includes a listing of research gap and future research directions for the field of biodegradable Zn.

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“…In this experiment, all equipment and materials were sterilized by autoclaving at 121°C for 20 min. The bacterial strains, including 20 mL nutrient broth, 0.23 g of antibacterial samples, and 2 mL bacterial suspension containing E. coli and S. aureus species, respectively, were cultured in gas bath thermostatic shaker with 150 rpm/min at 37.5°C and the absorbance of blank control bacterial strains was tested to 0.5 McFarland standard at 600 nm [37]. Then, 100 μL the above bacterial suspension was diluted into different times in a petri dish and cultured in gas bath thermostatic shaker at 37.5°C for 24 h. Finally, the images of antibacterial effect were analyzed by formula (3) [38][39][40].…”

Section: Antibacterial Properties Of Resin Compositesmentioning

confidence: 99%

One-pot synthesis of acrylate resin and ZnO nanowires composite for enhancing oil absorption capacity and oil-water separation

Chi

et al. 2018

Adv Compos Hybrid Mater

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Inspired by the fast separation of oils, we synthesized a multi-functional oil-absorbable material, ZnO nanowires/acrylic ester composite resin, via a facile and cost-effective suspension polymerization method. Especially, the ZnO nanowires were fabricated by hydrothermal method and the surface of superhydrophobic and superoleophilic ZnO nanowires was modified by A151. Various technologies such as FT-IR, XRD, SEM, and DSC-TG have been used to investigate the properties of the assynthesized materials. The corresponding oil absorption results showed that the composite resins could effectively separate organics from wastewater. Moreover, the composite resins were proved to have an excellent reusability after 10 cycles and the antibacterial activity of the synthesized composite resins mixed with ZnO nanowires were confirmed against E. coli and S. aureus, which could play an important role in water purification. Herein, the as-synthesized multi-functional oil-absorbable resins possess a far-reaching application prospect in the field of environmental treatment.

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Fabrication of biodegradable Zn-Al-Mg alloy: Mechanical properties, corrosion behavior, cytotoxicity and antibacterial activities

Cited by 154 publications

References 18 publications

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

The Prospects of Zinc as a Structural Material for Biodegradable Implants—A Review Paper

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

One-pot synthesis of acrylate resin and ZnO nanowires composite for enhancing oil absorption capacity and oil-water separation

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