Fabrication of biodendrimeric β-cyclodextrin via click reaction with potency of anticancer drug delivery agent

Folic Acid-Decorated β-Cyclodextrin-Based Poly(ε-caprolactone)-dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy

“…Click conjugations between alkyne and azido groups are widely used to prepare star polymers [36,44]. Herein, via a click conjugation method between alkyne-SS-Dex and ((N 3 ) 7 -βCD-(PCL) 14 ) to obtain the star polymer, (Dex-SS) n -βCD-(PCL) 14 was produced.…”

“…Natural β-cyclodextrin (βCD), which is linked with α-1, 4-glucosidic linkages and 7 α-D-glucose units, and β-cyclodextrin-based star polymers have played a significant role in biomedical engineering [32][33][34]. Hassan and co-workers reported the synthesis of biodendrimeric β-cyclodextrin as a drug nanocarrier by attaching βCD residues to the primary or secondary face of the core βCD via a click reaction [35,36]. Seven poly(ester) dendrons were selectively attached to the primary face of βCD via a click reaction, and the product as a drug carrier greatly improved the water solubility of albendazole [37].…”

Bifunctional folic-conjugated aspartic-modified Fe3O4 nanocarriers for efficient targeted anticancer drug delivery

“…7,8 Nevertheless, several shortcomings oen limit an effective DOX administration due to its high cardiotoxicity, low bioavailability and solubility, short bloodstream half-life, and non-specicity. [9][10][11] Therefore, current strategies focus on developing a targeted drug delivery system to ensure drug administration at target cancer cells and avoid unnecessary systemic distribution. During the past several years, numerous efforts have been made to develop an efficient and effective anticancer drug carrier.…”

Folic Acid Decorated <em>β</em>-Cyclodextrin-Based Poly(ε-Caprolactone)/Dextran Star Polymer with Disulfide Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy

“…Natural β-cyclodextrin (βCD), which is linked with α-1, 4-glucosidic linkages and 7 α-D-glucose units, and β-cyclodextrin base star polymers have played a significant role in biomedical engineering [31,32]. Hassan and coworkers reported the synthesis of biodendrimeric β-cyclodextrin as drug nanocarriers by attaching βCD residues to the primary or secondary face of the core βCD via a click reaction [33,34]. Seven poly(ester) dendrons were selectively attached to the primary face of βCD via click chemistry, and the product as a drug carrier greatly improved the water solubility of albendazole [35].…”

“…Synthesis of star polymer (Dex-SS)n-βCD-(PCL)14 by click reactionClick conjugations between alkyne and azido groups are widely used to prepare star polymers[34,42]. Herein, via a click conjugation method between alkyne-SS-Dex and ((N3)7-βCD-(PCL)14) to obtain the star polymer (Dex-SS)n-βCD-(PCL)14 was.…”