Fabrication of blend biodegradable nanofibrous nonwoven mats via multi-jet electrospinning

Ding, Bin; Kimura, Eiji; Sato, Tomokazu; Fujita, Shiro; Shiratori, Seimei

doi:10.1016/j.polymer.2004.01.026

Cited by 353 publications

(201 citation statements)

References 25 publications

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“…29,[86][87][88] These systems may be used to create composite scaffolds (with a different polymer in each jet) whose properties reflect the properties and ratios of the individual components. [89][90][91][92][93][94] Several such multicomponent scaffolds are described in detail below.…”

Section: Mechanical Properties Of Nanofibrous Assembliesmentioning

confidence: 99%

Engineering on the Straight and Narrow: The Mechanics of Nanofibrous Assemblies for Fiber-Reinforced Tissue Regeneration

Mauck

Baker

Nerurkar

et al. 2009

Tissue Engineering Part B: Reviews

191

177

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Tissue engineering of fibrous tissues of the musculoskeletal system represents a considerable challenge because of the complex architecture and mechanical properties of the component structures. Natural healing processes in these dense tissues are limited as a result of the mechanically challenging environment of the damaged tissue and the hypocellularity and avascular nature of the extracellular matrix. When healing does occur, the ordered structure of the native tissue is replaced with a disorganized fibrous scar with inferior mechanical properties, engendering sites that are prone to re-injury. To address the engineering of such tissues, we and others have adopted a structurally motivated approach based on organized nanofibrous assemblies. These scaffolds are composed of ultrafine polymeric fibers that can be fabricated in such a way to recreate the structural anisotropy typical of fiber-reinforced tissues. This straight-and-narrow topography not only provides tailored mechanical properties, but also serves as a 3D biomimetic micropattern for directed tissue formation. This review describes the underlying technology of nanofiber production and focuses specifically on the mechanical evaluation and theoretical modeling of these structures as it relates to native tissue structure and function. Applying the same mechanical framework for understanding native and engineered fiber-reinforced tissues provides a functional method for evaluating the utility and maturation of these unique engineered constructs. We further describe several case examples where these principles have been put to test, and discuss the remaining challenges and opportunities in forwarding this technology toward clinical implementation.

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Section: Mechanical Properties Of Nanofibrous Assembliesmentioning

confidence: 99%

Engineering on the Straight and Narrow: The Mechanics of Nanofibrous Assemblies for Fiber-Reinforced Tissue Regeneration

Mauck

Baker

Nerurkar

et al. 2009

Tissue Engineering Part B: Reviews

191

177

View full text Add to dashboard Cite

show abstract

“…Many researchers have used multiple spinnerets in order to increase the productivity Ref. Multiple needle tips were used by Ding et al 72 to electrospun blend of PVA and cellulose acetate. They produced nano fibres with various weight ratios of PVA and cellulose acetate by using four tips and varying the number containing PVA and cellulose acetate.…”

Section: Parameters Related To Setupmentioning

confidence: 99%

Nano Fibres by Electro spinning: Properties and Applications

Nayak¹,

Padhye²

2017

JTEFT

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Electro spinning is a simple and versatile technique applicable to a wide range of polymers and solvents for the production of materials in nanometer scale. The nano fibrous materials produced by electro spinning process exhibit novel and significantly improved physical, chemical and biological properties. The small fibre diameter and the porous structure of the electrospun surfaces enable them for a wide range of applications such as wound dressing, tissue engineering scaffolds, vascular grafts, filters, membranes and sensors. In this article the principle, setup, materials used and the factors affecting the electro spinning process have been described. Also the properties & applications of electrospun fibres and the limitations & future scope of electro spinning process have been highlighted.

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“…In this approach, natural and synthetic polymers are placed in two separate containers and electrospun simultaneously to form a natural/synthetic nanofibrous composite. For example, poly(vinyl alcohol) (PVA) and cellulose acetate (CA) are electrospun onto the same target area [156]. With this method, PVA and CA nanofibers disperse into each other as a direct result of physical blending.…”

Section: Synthetic-synthetic Compositesmentioning

confidence: 99%

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

Li¹,

Shanti²,

Tuan³

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction Nanofibrous Scaffolds Fabrication Methods for Nanofibrous Scaffolds Phase Separation Self‐assembly Electrospinning The Electrospinning Process History Setup Mechanism and Working Parameters Properties of Electrospun Nanofibrous Scaffolds Architecture Porosity Mechanical Properties Current Development of Electrospun Nanofibrous Scaffolds in Tissue Engineering Evidence Supporting the Use of Nanofibrous Scaffolds in Tissue Engineering Nanofibrous Scaffolds Enhance Adsorption of Cell Adhesion Molecules Nanofibrous Scaffolds Induce Favorable Cell– ECM Interaction Nanofibrous Scaffolds Maintain Cell Phenotype Nanofibrous Scaffolds Support Differentiation of Stem Cells Nanofibrous Scaffolds Promote in vivo ‐like 3 D Matrix Adhesion and Activate Cell Signaling Pathway Biomaterials Electrospun into Nanofibrous Scaffolds Natural Polymeric Nanofibrous Scaffolds Synthetic Polymeric Nanofibrous Scaffolds Composite Polymeric Nanofibrous Scaffolds Nanofibrous Scaffolds Coated with Bioactive Molecules Engineered Tissues using Electrospun Nanofibrous Scaffolds Skin Blood Vessel Cartilage Bone Muscle Ligament Nerve Current Challenges and Future Directions Conclusion

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Fabrication of blend biodegradable nanofibrous nonwoven mats via multi-jet electrospinning

Cited by 353 publications

References 25 publications

Engineering on the Straight and Narrow: The Mechanics of Nanofibrous Assemblies for Fiber-Reinforced Tissue Regeneration

Engineering on the Straight and Narrow: The Mechanics of Nanofibrous Assemblies for Fiber-Reinforced Tissue Regeneration

Nano Fibres by Electro spinning: Properties and Applications

Electrospinning Technology for Nanofibrous Scaffolds in Tissue Engineering

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