Fabrication of cell penetrating peptide labelled biodegradable poly(methacrylamide) nanoparticles for delivery of doxorubicin in HeLa cells

Devi, Neha; Cokca, Ceren; Kumar, M. Vijaya; Peneva, Kalina; Sharma, Rohit K.; Wangoo, Nishima

doi:10.1016/j.mtcomm.2022.104233

Cited by 1 publication

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The stretching peaks at 2980 and 1705 cm –1 due to the −CH 2 and −CO groups were also observed. The shift in the peak position and intensity of the OH, NH 2 , and −CO groups confirmed the conjugation of DOX over the surface of Cdots …”

Section: Resultsmentioning

confidence: 62%

“…The shift in the peak position and intensity of the OH, NH 2 , and −C�O groups confirmed the conjugation of DOX over the surface of Cdots. 43 The standard calibration curve was plotted for the quantification of DOX using fluorescence spectroscopy. The DL and EE of the Cdots-DOX conjugates were calculated to be 32.08 μg and 64.16%, respectively, which showed that the synthesized conjugates may have potential in cancer treatment.…”

Section: Resultsmentioning

confidence: 99%

“…The synthesis of Cdots-DOX conjugates was carried out via electrostatic interactions between the carboxyl and hydroxyl groups, which are present on the surface of the Cdots and DOX, respectively. 43 For this, Cdots were mixed with DOX concentrations ranging from 5 to 50 μg. It was incubated overnight at 37 °C.…”

Section: Synthesis Of Cdots-dox Conjugatesmentioning

confidence: 99%

See 2 more Smart Citations

Tuning the Luminescence of Microwave-Assisted N-Doped Fluorescent Carbon Dots: Bioimaging Applications and Label-Free Anti-Cancer Drug Delivery

Devi

Wangoo

2023

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

Nanosized fluorescent carbon dots (Cdots) have gained a lot of attention in the recent years because of their superior properties, such as good biocompatibility, low toxicity, excellent chemical stability, resistance to photobleaching, and ease of chemical modification. Cdots are promising candidates for considerable applications in various fields: sensors, bioimaging, and drug delivery. Specifically, nitrogen-doped Cdots have attracted a huge interest because of their applicability in bioimaging and drug delivery. Conventional methods for the synthesis of Cdots have drawbacks, such as the use of organic solvents, the presence of side products, and the time required for synthesis. Keeping all these points in mind, herein, we report green methodology for the synthesis of water-soluble, blueemitting, nitrogen-doped multifunctional Cdots under microwave irradiation within 3 min. The Cdots were prepared using citric acid and arginine as source materials and were characterized using various physicochemical techniques. A pH-responsive drug delivery system was then designed using anticancer drug doxorubicin and the synthesized Cdots. The biocompatibility of synthesized Cdots was analyzed against L929 normal cell line. The Cdots-DOX conjugates exhibited efficient anticancer activity against HeLa cells and also acted as excellent bioimaging agents.

show abstract

Section: Resultsmentioning

confidence: 62%

Section: Resultsmentioning

confidence: 99%