Fabrication of chitin–chitosan/nano ZrO2 composite scaffolds for tissue engineering applications

Jayakumar, R.; Ramachandran, Roshni; Divyarani, V.V.; Chennazhi, K.P.; Tamura, Hiroshi; Nair, Shantikumar V.

doi:10.1016/j.ijbiomac.2011.04.020

Cited by 107 publications

(38 citation statements)

References 26 publications

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“…Swelling increases the pore sizes, thus maximizing the surface area/volume ratio, and facilitates the infiltration of cells into the 3-D scaffolds during cell culture [42]. The swelling studies of the GH cryogels indicated their very high swelling capacity and the ability to retain more water than their original weight.…”

Section: Discussionmentioning

confidence: 99%

Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies

2013

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Section: Discussionmentioning

confidence: 99%

Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies

2013

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“…Previous studies on bone tissue engineering have reported the effect of polymer addition on mechanical properties of bioceramics (Gao et al, ; Jayakumar et al, ; Kim et al, ; Martínez‐Vázquez, Perera, Miranda, Pajares, & Guiberteau, ). Martínez‐Vázquez et al have investigated the effect of biodegradable polymer (polylactic acid [PLA] and poly [ϵ‐caprolactone] [PCL]) on the compressive strength of TCP scaffolds using a robocasting method.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies on bone tissue engineering have reported the effect of polymer addition on mechanical properties of bioceramics (Gao et al, 2013;Jayakumar et al, 2011;Kim et al, 2010;Martínez-Vázquez, Perera, Miranda, Pajares, & Guiberteau, 2010) In addition, many studies have concentrated on the fabrication of bioceramic-bioceramic composite scaffolds to increase cell proliferation and compressive strength (Ahn, Lee, Seol, Pyo, & Lee, 2013;An et al, 2012;Fielding, Bandyopadhyay, & Bose, 2012;Liu, Shen, & Lee, 2012;Padmanabhan et al, 2013;Tiainen, Eder, Nilsen, & Haugen, 2012).…”

mentioning

confidence: 99%

Fabrication and evaluation of 3D printed BCP scaffolds reinforced with ZrO₂ for bone tissue applications

Sa¹,

Nguyen

Moriarty

et al. 2018

Biotech & Bioengineering

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Fused deposition modeling (FDM) is a promising 3D printing and manufacturing step to create well interconnected porous scaffold designs from the computer-aided design (CAD) models for the next generation of bone scaffolds. The purpose of this study was to fabricate and evaluate a new biphasic calcium phosphate (BCP) scaffold reinforced with zirconia (ZrO ) by a FDM system for bone tissue engineering. The 3D slurry foams with blending agents were successfully fabricated by a FDM system. Blending materials were then removed after the sintering process at high temperature to obtain a targeted BCP/ZrO scaffold with the desired pore characteristics, porosity, and dimension. Morphology of the sintered scaffold was investigated with SEM/EDS mapping. A cell proliferation test was carried out and evaluated with osteosarcoma MG-63 cells. Mechanical testing and cell proliferation evaluation demonstrated that 90% BCP and 10% ZrO scaffold had a significant effect on the mechanical properties maintaining a structure compared that of only 100% BCP with no ZrO . Additionally, differentiation studies of human mesenchymal stem cells (hMSCs) on BCP/ZrO scaffolds in static and dynamic culture conditions showed increased expression of bone morphogenic protein-2 (BMP-2) when cultured on BCP/ZrO scaffolds under dynamic conditions compared to on BCP control scaffolds. The manufacturing of BCP/ZrO scaffolds through this innovative technique of a FDM may provide applications for various types of tissue regeneration, including bone and cartilage.

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“…For example, an investigation into the photocatalytic activity of chitosan/ZnO composite nanoparticles synthesized through ionotropic gelation had been investigated and reported to exhibit a quenching effect on the free radical production of ZnO [20] highlighting its potential suitability for use as a UV filtering additive in cosmetic products. Work on the development of chitosan/TiO 2 composites has been reported but such findings generally involve chitosan as a form of scaffolding for the TiO 2 usually for tissue engineering [21] and ultrafiltration [22] applications. In this study, nanocomposite chitosan/TiO 2 particles were processed by spray drying, in a single step, and an investigation into the optical, thermal and morphological properties of the composite materials was carried out.…”

Section: Introductionmentioning

confidence: 99%

Suppression of the photocatalytic activity of TiO 2 nanoparticles encapsulated by chitosan through a spray-drying method with potential for use in sunblocking applications

et al. 2018

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K. (2018). Suppression of the photocatalytic activity of TiO2 nanoparticles encapsulated by chitosan through a spray-drying method with potential for use in sunblocking applications. Powder Technology, 329 252-259. AbstractSolar exposure, in particular to UVA and UVB radiation, is a major carcinogen through direct DNA damage and the production of reactive oxygen species (ROS). Inorganic UV filters present in sunscreening agents, such as titanium dioxide (TiO 2 ), are commonly employed for protection however, due to their photocatalytic nature, they have been shown to instigate the production of ROS when irradiated with UV radiation, which in turn can lead to the degradation of the sunscreening formulation and subsequent damage to the skin. In this work, chitosan/TiO 2 nanocomposite particles were produced via a spray-drying method, in a single step, directly through aqueous solution for the purpose of reducing the photocatalytic activity of commercially available TiO 2 nanoparticles. The photocatalytic activity of the nanocomposite materials were assessed using the organic dye, crystal violet, as the degradation target and irradiating in a UV reactor. It was found that the photoactivity of the chitosan encapsulated nanoparticles were greatly reduced compared to that of the pristine TiO 2 nanoparticles, from 95% degradation after 120 min for pristine TiO 2 to 39.5% for the chitosan/TiO 2 spray dried particles, highlighting the potential for this simple coating process and chitosan material for application as an inactive protective coating for sunblocking applications. Disciplines Engineering | Physical Sciences and Mathematics Publication DetailsMorlando, A., Sencadas, V., Cardillo, D. & Konstantinov, K. (2018). Suppression of the photocatalytic activity of TiO2 nanoparticles encapsulated by chitosan through a spray-drying method with potential for use in sunblocking applications. Powder Technology, 329 252-259. AbstractSolar exposure, in particular to UVA and UVB radiation, is a major carcinogen through direct DNA damage and the production of reactive oxygen species (ROS). Inorganic UV filters present in sunscreening agents, such as titanium dioxide (TiO 2 ), are commonly employed for protection however, due to their photocatalytic nature, they have been shown to instigate the production of ROS when irradiated with UV radiation, which in turn can lead to the degradation of the sunscreening formulation and subsequent damage to the skin. In this work, chitosan/TiO 2 nanocomposite particles were produced via a spray-drying method, in a single step, directly through aqueous solution for the purpose of reducing the photocatalytic activity of commercially available TiO 2 nanoparticles. The photocatalytic activity of the nanocomposite materials were assessed using the organic dye, crystal violet, as the degradation target and irradiating in a UV reactor. It was found that the photoactivity of the chitosan encapsulated nanoparticles were greatly reduced compared to that of the pristine TiO 2 nanoparticles, from 95% degr...

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Fabrication of chitin–chitosan/nano ZrO2 composite scaffolds for tissue engineering applications

Cited by 107 publications

References 26 publications

Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies

Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies

Fabrication and evaluation of 3D printed BCP scaffolds reinforced with ZrO₂ for bone tissue applications

Suppression of the photocatalytic activity of TiO 2 nanoparticles encapsulated by chitosan through a spray-drying method with potential for use in sunblocking applications

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Fabrication of chitin–chitosan/nano ZrO2 composite scaffolds for tissue engineering applications

Cited by 107 publications

References 26 publications

Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies

Preparation and characterization of gelatin/hyaluronic acid cryogels for adipose tissue engineering: In vitro and in vivo studies

Fabrication and evaluation of 3D printed BCP scaffolds reinforced with ZrO2 for bone tissue applications

Suppression of the photocatalytic activity of TiO 2 nanoparticles encapsulated by chitosan through a spray-drying method with potential for use in sunblocking applications

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Fabrication and evaluation of 3D printed BCP scaffolds reinforced with ZrO₂ for bone tissue applications