Fabrication of chitosan-gelatin films incorporated with thymol-loaded alginate microparticles for controlled drug delivery, antibacterial activity and wound healing: In-vitro and in-vivo studies

Ahmady, Azin Rashidy; Razmjooee, Kavoos; Saber-Samandari, Saeed; Toghraie, Davood

doi:10.1016/j.ijbiomac.2022.10.249

Cited by 62 publications

(18 citation statements)

References 85 publications

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“…It is worth noting that the levels of the antibacterial efficiency reached through the newly developed hydrogels are extremely high. Similar but not matched antibacterial performance have been reached in very few studies, − see Figure .…”

Section: Results and Discussionmentioning

confidence: 52%

Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications

Ruan,

Bek,

Pandit

et al. 2023

ACS Appl. Mater. Interfaces

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A facile novel approach of introducing dopamine and [2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide via dopamine-triggered in situ synthesis into gelatin hydrogels in the presence of ZnSO4 is presented in this study. Remarkably, the resulting hydrogels showed 99.99 and 100% antibacterial efficiency against Gram-positive and Gram-negative bacteria, respectively, making them the highest performing surfaces in their class. Furthermore, the hydrogels showed adhesive properties, self-healing ability, antifreeze properties, electrical conductivity, fatigue resistance, and mechanical stability from −100 to 80 °C. The added multifunctional performance overcomes several disadvantages of gelatin-based hydrogels such as poor mechanical properties and limited thermostability. Overall, the newly developed hydrogels show significant potential for numerous biomedical applications, such as wearable monitoring sensors and antibacterial coatings.

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Section: Results and Discussionmentioning

confidence: 52%

Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications

Ruan,

Bek,

Pandit

et al. 2023

ACS Appl. Mater. Interfaces

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“…aureus and were comparable to carbon-based materials reported elsewhere. ,, In addition, all of the results showed promising beneficial materials for wound dressing applications. However, fabrication processes as well as in vivo assessments of biocompatibility are still needed. − Therefore, carbon nanospheres should be further developed and utilized in preventive healthcare and medical devices, e.g., as drug nanocarriers and inhibition products.…”

Section: Resultsmentioning

confidence: 99%

Unraveling the Adsorption Behavior of Thymol on Carbon and Silica Nanospheres for Prolonged Antibacterial Activity: Experimental and DFT Studies

Sosa,

Phanthasri,

Yodsin

et al. 2023

ACS Appl. Bio Mater.

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Functionalization of thymol (Thy) on nanocarriers is a key step in achieving prolonged antimicrobial activity. This requires nanomaterials with uniform particle diameters and suitable thymol sorption. Herein, hollow carbon (HC) and SiO2-carbon core–shell (SiO2@C) were investigated due to their diverse morphologies and ease of surface modification. HC (14 ± 1 nm size) and SiO2@C (10 ± 1.5 nm size) were synthesized by the Stöber method before thymol was loaded by incipient wetness impregnation. Nanoparticle physicochemical properties were characterized by advanced techniques, including X-ray photoelectron spectroscopy (XPS) and near-edge X-ray absorption fine structure (NEXAFS). Adsorption energies of thymol on the carbon and SiO2 surfaces were elucidated by density functional theory (DFT) simulations. Moreover, the in vitro thymol release profiles and antibacterial activity were evaluated. The experimental results indicated that the oxy-carbon surface species of HC led to longer thymol release profiles than the –OH group of SiO2@C. The DFT calculations revealed that the weaker physical interaction of thymol on HC was better for drug release than that on SiO2@C. Thus, a longer thymol release profile of HC with hollow structures showed better antibacterial performance against Gram-positive bacteria Staphylococcus aureus than that of SiO2@C with core–shell structures. This work confirms the important role of carbon morphology and specific functional groups in thymol release profiles for the further development of inhibition products.

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“…To determine the drug release index and drug release kinetics of the hydrogel, the cumulative release curve was fitted to the following power law equation: M normalt M ∞ = K t n where M t and M ∞ are the drug cumulative amount at time t and release equilibrium, respectively; K is the rate constant; and n is the release index characterizing the release mechanism. The relationship between n -value results and released patterns are shown in Table . , …”

Section: Methodsmentioning

confidence: 99%

“…The relationship between n-value results and released patterns are shown in Table 1. 39,40 2.7. In Vitro Evaluation of Cell Adhesion of PCHgel Hydrogel.…”

Section: Methodsmentioning

confidence: 99%

Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions

Lang

Liu

Huang

et al. 2023

ACS Biomater. Sci. Eng.

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Tissue adhesions could occur following surgeries, and severe tissue adhesions can lead to serious complications. Medical hydrogels could be applied at surgical sites as a physical barrier to prevent tissue adhesion. For practical reasons, spreadable, degradable, and self-healable gels are highly demanded. To meet these requirements, we applied carboxymethyl chitosan (CMCS) to poloxamer-based hydrogels to generate low Poloxamer 338 (P 338 ) content gels displaying low viscosity at refrigerator temperature and improved mechanical strength at body temperature. Heparin, an effective adhesion inhibitor, was also added to construct P 338 /CMCS-heparin composite hydrogel (PCHgel). PCHgel presents as a flowable liquid below 20 °C and could rapidly transform into gel when spread on the surface of damaged tissue due to temperature change. The introduction of CMCS enabled hydrogels to form a stable self-healable barrier at injured positions and slowly release heparin during the wound healing period before being degraded after ∼14 days. Ultimately, PCHgel significantly reduced tissue adhesion in model rats and displayed higher efficiency than P 338 /CMCS gel without heparin. Its adhesion suppression mechanism was verified, and it also displayed good biosafety. Therefore, PCHgel showed good clinical transformation potential with high efficacy, good safety, and ease of use.

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Fabrication of chitosan-gelatin films incorporated with thymol-loaded alginate microparticles for controlled drug delivery, antibacterial activity and wound healing: In-vitro and in-vivo studies

Cited by 62 publications

References 85 publications

Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications

Biomimetic Antibacterial Gelatin Hydrogels with Multifunctional Properties for Biomedical Applications

Unraveling the Adsorption Behavior of Thymol on Carbon and Silica Nanospheres for Prolonged Antibacterial Activity: Experimental and DFT Studies

Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions

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