Fabrication of chitosan nanocomposites loaded with biosynthetic metallic nanoparticles and their therapeutic investigation

Gracias, Slavika; Ayyanar, Muniappan; Peramaiyan, Gangapriya; Kalaskar, Mohan; Redasani, Vivek; Gurav, Nilambari; Nadaf, Sameer; Deshpande, Mangirish; Bhole, Ritesh; Khan, Mohd Shahnawaz; Chikhale, Rupesh; Gurav, Shailendra

doi:10.1016/j.envres.2023.116609

Cited by 16 publications

(1 citation statement)

References 80 publications

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“…Particle-based drug delivery systems present advantages compared to other systems due to their small dimensions, high surface-to-volume ratio, higher circulation time, improved antibacterial activity, and enhanced biocompatibility [ 1 , 2 ]. A variety of micro- and nanostructures, such as polymeric [ 3 , 4 ], lipidic [ 5 , 6 ], metallic [ 7 , 8 ], ceramic [ 9 ], or carbon-based [ 10 , 11 ] have been reported as promising drug delivery systems. Among various types of microparticles, those based on natural and synthetic polymers are particularly preferred in drug delivery applications due to their higher encapsulation capacity, biocompatibility, biodegradability, and improved cellular uptake.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Polymeric Microparticles Based on Poly(ethylene brassylate-co-squaric Acid) Loaded with Norfloxacin

Șerban,

Nacu,

Rosca

et al. 2024

Pharmaceutics

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In recent years, increasing interest has been accorded to polyester-based polymer microstructures, driven by their promising potential as advanced drug delivery systems. This study presents the preparation and characterization of new polymeric microparticles based on poly(ethylene brassylate-co-squaric acid) loaded with norfloxacin, a broad-spectrum antibiotic. Polymacrolactone was synthesised in mild conditions through the emulsion polymerization of bio-based and renewable monomers, ethylene brassylate, and squaric acid. The microparticles were obtained using the precipitation technique and subsequently subjected to comprehensive characterization. The impact of the copolymer/drug ratio on various properties of the new system was systematically evaluated, confirming the structure of the copolymer and the encapsulation of norfloxacin. The microspheres are approximately spherical and predominantly homogeneously distributed. The average hydrodynamic diameter of the microparticles falls between 400 and 2000 nm, a decrease that is observed with the increase in norfloxacin content. All samples showed good encapsulation efficiency and drug loading capacity, with the highest values obtained for microparticles synthesised using an equal ratio of copolymer and drug. In vitro drug release results disclose that norfloxacin molecules are released in a sustained biphasic manner for up to 24 h. Antimicrobial activity was also studied, with samples showing very good activity against E. coli and moderate activity against S. aureus and E. faecalis. In addition, HDFA human fibroblast cell cultures demonstrated the cytocompatibility of the microparticles.

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Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Polymeric Microparticles Based on Poly(ethylene brassylate-co-squaric Acid) Loaded with Norfloxacin

Șerban,

Nacu,

Rosca

et al. 2024

Pharmaceutics

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Nano‐informatics Approach to Unravel the Intrinsic Interaction of Catharanthus roseus Fabricated Zinc Oxide Nanoparticles with Vindoline to Combat Diabetes

Goyal,

Kumar,

Mallick

et al. 2024

ChemistrySelect

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An important aspect of the treatment of chronic cases of diabetes is the enhancement of insulin secretion with a decrease in intestinal glucose absorption. In this study, the prepared alcoholic Catharanthus roseus flower extract‐fabricated zinc oxide nanoparticles (FZNPs) were characterized by UV–vis spectrometer, dynamic light scattering (DLS), X‐ray diffraction (XRD), and fourier transform infrared spectroscopy (FTIR) instruments and antihyperglycemic properties were tested at the molecular level by the in silico method. The synthesis of FZNPs is possible, and the characterization report showed that they have maximum optical properties at 361 nm, a small grain size (15.68 nm), and negative zeta potential (hydrophilic nature). The nanoparticles have a hexagonal structure and are surrounded by several functional groups. The in silico result supports that zinc oxide and related structures, as well as Zn (II) diisophthalate and vindoline, have good ADMET properties. The Zn(II) diisophthalate lead interaction tested with alpha‐glucosidase and has a binding affinity of ‐6.3 kcal/mol, whereas vindoline and KATP binding affinity ‐7.4 kcal/mol. The synthesized FZNPs have the ability to inhibit alpha‐glucosidase targets and block the KATP ion channel of beta cells. The FZNPs have the ability to reduce intestinal glucose absorption as well as promote insulin secretion, so they can effectively manage the hyperglycaemic condition of patients.

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Endophytic Fungus Colletotrichum siamense Derived Silver Nanoparticles: Biomimetic Synthesis, Process Optimization and Their Biomedical Applications

Andrade,

Jenipher,

Gurav

et al. 2024

J Inorg Organomet Polym

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Fabrication of chitosan nanocomposites loaded with biosynthetic metallic nanoparticles and their therapeutic investigation

Cited by 16 publications

References 80 publications

Preparation and Characterization of Polymeric Microparticles Based on Poly(ethylene brassylate-co-squaric Acid) Loaded with Norfloxacin

Preparation and Characterization of Polymeric Microparticles Based on Poly(ethylene brassylate-co-squaric Acid) Loaded with Norfloxacin

Nano‐informatics Approach to Unravel the Intrinsic Interaction of Catharanthus roseus Fabricated Zinc Oxide Nanoparticles with Vindoline to Combat Diabetes

Endophytic Fungus Colletotrichum siamense Derived Silver Nanoparticles: Biomimetic Synthesis, Process Optimization and Their Biomedical Applications

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