Fabrication of chitosan oligomer-coated electrospun polycaprolactone membrane for wound dressing application

Ho, Trinh Thi-Phuong; Doan, Vinh Khanh; Tran, Nam H.; Nguyen, Linh Kim-Khanh; Le, An N.; Ho, Minh Hieu; Trinh, Nhu‐Thuy; Vo, Toi Van; Tran, Lam Dai; Nguyen, Thi‐Hiep

doi:10.1016/j.msec.2020.111724

Cited by 45 publications

(19 citation statements)

References 45 publications

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“…Chitosan, due to its biological and physico-chemical properties, is commonly used as membrane components that have a variety of applications, such as wound healing membranes [211][212][213][214][215], antibacterial membranes [216][217][218][219], membranes [220] and drug carrier systems [221][222][223].…”

Section: Chitosan Membranesmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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Chitosan is one of the most well-known and characterized materials applied in tissue engineering. Due to its unique chemical, biological and physical properties chitosan is frequently used as the main component in a variety of biomaterials such as membranes, scaffolds, drug carriers, hydrogels and, lastly, as a component of bio-ink dedicated to medical applications. Chitosan’s chemical structure and presence of active chemical groups allow for modification for tailoring material to meet specific requirements according to intended use such as adequate endurance, mechanical properties or biodegradability time. Chitosan can be blended with natural (gelatin, hyaluronic acid, collagen, silk, alginate, agarose, starch, cellulose, carbon nanotubes, natural rubber latex, κ-carrageenan) and synthetic (PVA, PEO, PVP, PNIPPAm PCL, PLA, PLLA, PAA) polymers as well as with other promising materials such as aloe vera, silica, MMt and many more. Chitosan has several derivates: carboxymethylated, acylated, quaternary ammonium, thiolated, and grafted chitosan. Its versatility and comprehensiveness are confirming by further chitosan utilization as a leading constituent of innovative bio-inks applied for tissue engineering. This review examines all the aspects described above, as well as is focusing on a novel application of chitosan and its modifications, including the 3D bioprinting technique which shows great potential among other techniques applied to biomaterials fabrication.

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Section: Chitosan Membranesmentioning

confidence: 99%

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Kołodziejska¹,

Jankowska²,

Klak³

et al. 2021

Nanomaterials

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“…They should also act as a dermal substitute, and be permeable to provide gas exchange for promoting normal tissue repair [ 324 ]. Wound dressings should be durable and flexible to prevent the need for restricting motion during healing, maintaining integrity during application [ 324 , 325 ]. The wound-healing process can be promoted by releasing bioactive molecules from the wound dressing that maintain favorable healing environments supportive of tissue regeneration.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Polysaccharide-based materials have been extensively proposed as wound dressings due to their cytocompatibility, biodegradability, anticoagulant, and hemostatic properties [ 322 , 327 ]. Chitosan stimulates hemostasis, accelerating the blood clotting process and tissue regeneration [ 325 ]. Chitosan-based materials also exhibit antimicrobial activities, as discussed above, thereby protecting wounds from infection during tissue healing [ 328 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…The definition of wound dressing materials is often incorrectly presented in the literature. Scaffolds are frequently referred to as wound dressings; however, the main function of scaffolds is to accelerate the wound-healing process [ 322 , 325 ]. Scaffolds are not wound dressings because these materials interact with damaged tissues during the healing process, and cannot be removed from the tissue without causing pain or potentially damaging the wound site.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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“…As the first protective barrier against a harsh environment, skin inevitably causes trauma. Although the skin has a certain self-healing ability, the side effects such as inflammation and secondary damage accompanying the long-term repair process make it of great demand in designing and developing clinical wound dressings [ 3 , 4 ]. Up to now, many different types of wound dressings have been designed, among which hydrogel-based wound dressings have attracted much attention [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Zhang

Xiao-rui

et al. 2021

Marine Drugs

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Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

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Fabrication of chitosan oligomer-coated electrospun polycaprolactone membrane for wound dressing application

Cited by 45 publications

References 45 publications

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

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