Fabrication of CO-releasing surface to enhance the blood compatibility and endothelialization of TiO2 nanotubes on titanium surface

Ma, Wenfu; Liu, Xuhui; Yang, Minhui; Hong, Qinghui; Meng, Lingjie; Zhang, Qiuyang; Chen, Jie; Pan, Changjiang

doi:10.1016/j.bioadv.2023.213393

Cited by 10 publications

(1 citation statement)

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“…Advancements in nanotechnology present promising opportunities to combat restenosis, lower reintervention rates, and reduce late‐stage adverse events after vascular procedures like angioplasty (Trepanier et al, 2023). Finally, nonpolymeric nanomaterials like titanium dioxide nanotubes and nitride coatings promote endothelial health and prevent SMC hyperproliferation (Karjalainen & Nammas, 2017; Ma et al, 2023). Alternatively, drug‐elution may be replaced by bioactive molecules such as DNA, genes, proteins, miRNA, siRNA, and antibodies.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology in development of next generation of stent and related medical devices: Current and future aspects

Islam,

Schaly,

Abosalha

et al. 2024

WIREs Nanomed Nanobiotechnol

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Coronary stents have saved millions of lives in the last three decades by treating atherosclerosis especially, by preventing plaque protrusion and subsequent aneurysms. They attenuate the vascular SMC proliferation and promote reconstruction of the endothelial bed to ensure superior revascularization. With the evolution of modern stent types, nanotechnology has become an integral part of stent technology. Nanocoating and nanosurface fabrication on metallic and polymeric stents have improved their drug loading capacity as well as other mechanical, physico‐chemical, and biological properties. Nanofeatures can mimic the natural nanofeatures of vascular tissue and control drug‐delivery. This review will highlight the role of nanotechnology in addressing the challenges of coronary stents and the recent advancements in the field of related medical devices. Different generations of stents carrying nanoparticle‐based formulations like liposomes, lipid‐polymer hybrid NPs, polymeric micelles, and dendrimers are discussed highlighting their roles in local drug delivery and anti‐restenotic properties. Drug nanoparticles like Paclitaxel embedded in metal stents are discussed as a feature of first‐generation drug‐eluting stents. Customized precision stents ensure safe delivery of nanoparticle‐mediated genes or concerted transfer of gene, drug, and/or bioactive molecules like antibodies, gene mimics via nanofabricated stents. Nanotechnology can aid such therapies for drug delivery successfully due to its easy scale‐up possibilities. However, limitations of this technology such as their potential cytotoxic effects associated with nanoparticle delivery that can trigger hypersensitivity reactions have also been discussed in this review.This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Section: Introductionmentioning

confidence: 99%