Fabrication of Cr doped SnO2 nanoparticles based biosensor for the selective determination of riboflavin in pharmaceuticals

Abstract

We report the fabrication and testing of a riboflavin (RF) biosensor based on the use of Cr doped SnO2 nanoparticles. The Cr-SnO2 nanoparticles with chromium concentration from 0 to 5 wt% were synthesised by a microwave irradiation method. Magnetic studies revealed that only 3 wt% Cr doped nano-SnO2 has ferromagnetic behaviour at room temperature. This Cr-SnO2 nanoparticles modified electrode responded to RF linearly over a concentration range of 0.2 × 10(-6) to 1.0 × 10(-4) M with a detection limit of 107 nM. The fabricated sensor showed an excellent anti-interference ability against electroactive species and metal ions and proved to be useful for the estimation of the RF content in pharmaceutical samples with satisfactory recovery.

WO3 nanoparticles based direct electrochemical dopamine sensor in the presence of ascorbic acid

“…In recent years, nanostructured metal oxides (NMOs) have been widely applied as sensing material in chemosensors and biosensors because of their high chemical stability, biocompatibility, structural flexibility, higher catalytic behaviour, and strong adherence to substrates [7][8][9]. The NMO based electrodes such as MnO 2 /chitosan [10], SWCNT/Fe 2 O 3 [11], Cu 2 O/graphene [12] and SiO 2 /ZrO 2 /methylene blue [13] have been explored for the detection of DA in the presence of AA.…”

Recent Advances in Electroanalysis of Vitamins

“…Some stripping voltammetric methods were developed at Bi film‐Cu , silver amalgam , dropping mercury electrode , heated graphite and DNA modified pencil electrode . Glassy carbon electrodes modified with several materials were also employed . Among those, it is worth mentioning the most innovative nanomaterials such as poly (3,4‐ethylenedioxythiophene)/zirconia nanocomposite reported in Figure , OLA‐NiO/MWCNTs nanocomposites , nanocrystalline metallosilicate , polythiophene nanotube arrays and nano Cr/SnO .…”

Simultaneous electrochemical determination of epinephrine and uric acid in the presence of ascorbic acid using SnO2/graphene nanocomposite modified glassy carbon electrode

“…have attracted much attention recently due to their improved electrochemical properties in various applications [11][12][13][14][15][16]. Among them, SnO 2 , an n-type semiconductor with high surface area, good biocompatibility and high environmental stability, has been used to fabricate both resistive sensors for humidity and gases [17], and electrochemical sensors for a variety of analytes such as hydrogen peroxide [18], glucose [19], riboflavin [20], folic acid [21] and pesticides [22]. SnO 2 NPs have become important as immobilization matrices for the fabrication of biosensors, as they provide excellent optical and electrical properties due to electron and phonon confinement, isoelectric point (5.5), high surface reactivity and catalytic activity along with strong adsorption ability which results in enhanced electron transfer and improved sensing characteristics.…”