Fabrication of curcumin-loaded mesoporous silica incorporated polyvinyl pyrrolidone nanofibers for rapid hemostasis and antibacterial treatment

Li, Dejian; Nie, Wei; Chen, Liang; Miao, Yingke; Zhang, Xu; Chen, Fancheng; Yu, Bin; Ao, Rongguang; Yu, Baoqing; He, Chuanglong

doi:10.1039/c6ra27319j

Cited by 71 publications

(27 citation statements)

References 26 publications

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“…To improve its flexibility, CO and PVP were added. 32,37,38 The results demonstrated that the elongation of the films was then greatly improved. In particular, the PVB/CO/ST had better tensile strength and elongation at break for the same thickness of film and thus was selected for subsequent experiments.…”

Section: Discussionmentioning

confidence: 91%

Silver triethanolamine-loaded PVB/CO films for a potential liquid bandage application

2019

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Many studies have reported that silver has excellent antibacterial properties. However, silver ions can easily react with oxygen to form Ag2O, thus leading to a color change and a reduction in its anti-microbial characteristics. In this study, silver triethanolamine- (ST) loaded PVB/CO solution was prepared as a potential candidate liquid bandage. PVB/CO/ST retained high transparency after exposure to light for 12 months, which allowed convenient inspection of the wound bed without removal of the dressing. The PVB/CO/ST film exhibited favorable properties, such as speed of drying, excellent tensile strength and elongation characteristics and water vapor transmission rate (WVTR). It was comfortable and waterproof, and therefore effective at preventing bacterial invasion, providing effective biosafety. PVB/CO/ST solution-treated wounds exhibited accelerated healing and reduced inflammation in a nude mouse mode. Our data suggested that PVB/CO/ST solution could serve as a promising liquid bandage for treatment of minor trauma.

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Section: Discussionmentioning

confidence: 91%

Silver triethanolamine-loaded PVB/CO films for a potential liquid bandage application

2019

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“…He and co‐workers developed an organic–inorganic hybrid hemostatic material by incorporating curcumin‐loaded MS NPs into PVP nanofiber mats by electrospinning . In vitro cytotoxic studies demonstrated that the hybrid nanofiber mats had no obvious toxic effect on the growth of murine L929 fibrosarcoma cells.…”

Section: Ms In Antibacterial Applicationsmentioning

confidence: 99%

Mesoporous Silica‐Based Materials with Bactericidal Properties

Bernardos

Piacenza

Sancenón

et al. 2019

Small

146

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Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.

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“…Hybrid nanofibers also exhibit enhanced in vitro antibacterial effects against methicillin‐resistant Staphylococcus aureus. Animal liver experiments have shown that fibers can be rapidly converted to hydrogels upon contact with blood and produce good hemostatic effects …”

Section: Hemostasis At Nanoscalementioning

confidence: 99%

Recent Advances in Hemostasis at the Nanoscale

Wang

Liu

Sui

et al. 2019

Adv Healthcare Materials

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Rapid and effective hemostatic materials have received wide attention not only in the battlefield but also in hospitals and clinics. Traditional hemostasis relies on materials with little designability which has many limitations. Nanohemostasis has been proposed since the use of peptides in hemostasis. Nanomaterials exhibit excellent adhesion, versatility, and designability compared to traditional materials, laying a good foundation for future hemostatic materials. This review first summarizes current hemostatic methods and materials, and then introduces several cutting‐edge designs and applications of nanohemostatic materials such as polypeptide assembly, electrospinning of cyanoacrylate, and nanochitosan. Particularly, their advantages and working mechanisms are introduced. Finally, the challenges and prospects of nanohemostasis are discussed.

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Fabrication of curcumin-loaded mesoporous silica incorporated polyvinyl pyrrolidone nanofibers for rapid hemostasis and antibacterial treatment

Abstract: A new hemostasis material composed of curcumin-loaded mesoporous silica and polyvinyl pyrrolidone nanofibers with rapid hemostasis and antibacterial ability.

Cited by 71 publications

References 26 publications

Silver triethanolamine-loaded PVB/CO films for a potential liquid bandage application

Silver triethanolamine-loaded PVB/CO films for a potential liquid bandage application

Mesoporous Silica‐Based Materials with Bactericidal Properties

Recent Advances in Hemostasis at the Nanoscale

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