The fast growth of radiofrequency identification (RFID) research is currently exploring new applications for body-centric systems where flexible, miniaturized and conformal antennas are required for placement over the human body and implantation inside limbs and internal organs. When compared with conventional antennas for body-centric purpose, the design of RFID tags involve additional challenges related to the absence of local power source and, in some cases, to the close interaction with the interrogating unit.This chapter reviews the state of the art in the design and experimentation of flexible and conformable antennas for body-centric RFID applications with great attention to the definition of the performance parameters, the achievable read range, and finally, the technology solutions. For the most challenging family of implantable antennas, two cases study are given concerning design and experimentation of tags for orthopaedic limb prosthesis and for vascular implants.The RFID body-centric communication modalities can involve off-body, onbody and through-the body links (Fig. 1). The off-body communication could be useful for locating and monitoring people inside buildings, by means of fixed readers placed in different rooms, or by an on-body reader and ambient disseminated tags [1]. A possible application is the access control in dangerous or restricted areas. The on-body link, wherein the reader antenna is placed over the body, is instead typical of unusual scenarios, where a fixed communications infrastructure is missing. This could be the case of a sportsman, a soldier, or a fireman equipped with different RFID sensors (inside a garment), interrogated by the user's handheld standard communicator in harsh environments [2,3]. Finally, the most challenging architecture is the through-the body link wherein a tag is implanted inside the human body to realize 'augmented' prosthesis or artificial organs, adding communication and sensing capabilities [4,5] in order to store into the device itself detailed information about model, the surgery event as well as to collect data about its health state. Accordingly, doctors and surgeons will be enable to track the medical process after the surgeryevent, thus reducing risk of mistake or early anomalous events, as well as to monitor the status of the implant in the surgery's follow-up.This chapter reviews the state of the art in the design and experimentation of wearable and implantable RFID antennas used as harvesting modules of an RFID tag, with great attention to the definition of the performance parameters, the achievable read range, and finally, the technology solutions to achieve flexible and conformal elements suited to be embedded into clothes, as well into existing biomedical devices. For the most challenging family of implantable antennas, two Figure 1: Sketch of RFID-powered body-centric system with wearable tags (WT) and implanted tags (IT) placed over and inside the human body, and interrogated by one or more RFID readers (R).