Fabrication of fucoxanthin/2-hydroxypropyl-β-cyclodextrin inclusion complex assisted by ultrasound procedure to enhance aqueous solubility, stability and antitumor effect of fucoxanthin

Sun, Xiaowen; Zhu, Junxiang; Liu, Chengqin; Wang, Dongfeng; Wang, Chang‐Yun

doi:10.1016/j.ultsonch.2022.106215

Cited by 18 publications

(7 citation statements)

References 43 publications

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“…10 A) . Based on Lamarckian genetic algorithm (LGA) and semi-flexible docking method, the simulation was carried out using AutoDock software and the binding free energy was used as the basis to evaluate the docking results [60] . It was turned out that their existed electrostatic interaction and three hydrogen bonds in SBE-β-CD@Lyc∙HCl.…”

Section: Resultsmentioning

confidence: 99%

Evaluation on the inclusion behavior of β-cyclodextrins with lycorine and its hydrochloride

Sun

et al. 2023

Journal of Molecular Liquids

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Section: Resultsmentioning

confidence: 99%

Evaluation on the inclusion behavior of β-cyclodextrins with lycorine and its hydrochloride

Sun

et al. 2023

Journal of Molecular Liquids

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“…The hexatomic side ring of astaxanthin was incorporated into the cavity of methyl-β-cyclodextrin to form a complex in an amorphous state, which was proved by the DSC thermogram, and the product exhibited 54-fold higher solubility, a 10-fold dissolution rate, and better bioaccessibility [ 88 ]. Sun et al [ 81 ] proposed fucoxanthin (FX)/2-hydroxylpropyl-β-cyclodextrin via sonication and spray drying. The results of FTIR revealed that the characteristic peaks of FX disappeared, indicating that FX may have been successfully encapsulated, and the molecular docking suggested hydrogen bonding between FX and 2-hydroxylpropyl-β-cyclodextrin.…”

Section: Approaches For the Crystalline Status Modification Of Carote...mentioning

confidence: 99%

“… Scheme diagrams of ( A ) cyclodextrin, ( B ) amylose, and ( C ) β-lactoglobulin inclusion complexes [ 81 , 82 , 83 ]. …”

Section: Figurementioning

confidence: 99%

Formulation Approaches to Crystalline Status Modification for Carotenoids: Impacts on Dissolution, Stability, Bioavailability, and Bioactivities

Liu

Hsieh

et al. 2023

Pharmaceutics

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Carotenoids, including carotenes and xanthophylls, have been identified as bioactive ingredients in foods and are considered to possess health-promoting effects. From a biopharmaceutical perspective, several physicochemical characteristics, such as scanty water solubility, restricted dissolution, and susceptibility to oxidation may influence their oral bioavailability and eventually, their effectiveness. In this review, we have summarized various formulation approaches that deal with the modification of crystalline status for carotenoids, which may improve their physicochemical properties, oral absorption, and biological effects. The mechanisms involving crystalline alteration and the typical methods for examining crystalline states in the pharmaceutical field have been included, and representative formulation approaches are introduced to unriddle the mechanisms and effects more clearly.

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“…Regarding betulinic acid, its microencapsulation in β-CD exerted anti-proliferation effects on human breast cancer cells [ 19 ]. Similarly, HPβCD enforced the antitumor activity of the marine-derived carotenoid fucoxanthin in human colorectal carcinoma cells in vitro [ 20 ]. Camptothecin, and its natural analogue luotonin A, are alkaloids isolated from Camptotheca acuminata and are both studied for their anticancer activities.…”

Section: Medicinal Applicationsmentioning

confidence: 99%

Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications

Christaki,

Spanidi,

Panagiotidou

et al. 2023

Pharmaceuticals

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Cyclodextrins have gained significant and established attention as versatile carriers for the delivery of bioactive compounds derived from natural sources in various applications, including medicine, food and cosmetics. Their toroidal structure and hydrophobic cavity render them ideal candidates for encapsulating and solubilizing hydrophobic and poorly soluble compounds. Most medicinal, food and cosmetic ingredients share the challenges of hydrophobicity and degradation that can be effectively addressed by various cyclodextrin types. Though not new or novel—their first applications appeared in the market in the 1970s—their versatility has inspired numerous developments, either on the academic or industrial level. This review article provides an overview of the ever-growing applications of cyclodextrins in the delivery of bioactive compounds from natural sources and their potential application benefits.

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Fabrication of fucoxanthin/2-hydroxypropyl-β-cyclodextrin inclusion complex assisted by ultrasound procedure to enhance aqueous solubility, stability and antitumor effect of fucoxanthin

Cited by 18 publications

References 43 publications

Evaluation on the inclusion behavior of β-cyclodextrins with lycorine and its hydrochloride

Evaluation on the inclusion behavior of β-cyclodextrins with lycorine and its hydrochloride

Formulation Approaches to Crystalline Status Modification for Carotenoids: Impacts on Dissolution, Stability, Bioavailability, and Bioactivities

Cyclodextrins for the Delivery of Bioactive Compounds from Natural Sources: Medicinal, Food and Cosmetics Applications

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