Fabrication of heparinized small diameter TPU/PCL bi-layered artificial blood vessels and in vivo assessment in a rabbit carotid artery replacement model

Fang, Zhiping; Xiao, Yonghao; Geng, Xue; Jia, Liujun; Xing, Yuehao; Ye, Lin; Gu, Yongquan; Zhang, Aiying; Feng, Zeng‐guo

doi:10.1016/j.msec.2021.112628

Cited by 24 publications

(11 citation statements)

References 46 publications

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“…The use of artificial blood vessels for vascular transplantation provides a new direction for the treatment of CVDs, 280 and further modification of artificial blood vessels is necessary to adapt to the complex environment in vivo. 281 Biobased artificial blood vessels are broadly used because of their standout biological activity. 282 An Arg-Glu-Asp-Val (REDV) peptide containing anticoagulant activity and alginate dialdehyde (ADA) are combined with biological amniotic membrane (AM) to form a stable structure of "double crosslinking".…”

Section: Medical Devices Based On Anticoagulant Macromoleculesmentioning

confidence: 99%

“…Although autologous blood vessel transplantation is the optimal choice for repairing defective blood vessels, it is limited by the source and the patient’s own health and other factors. The use of artificial blood vessels for vascular transplantation provides a new direction for the treatment of CVDs, and further modification of artificial blood vessels is necessary to adapt to the complex environment in vivo . Bio-based artificial blood vessels are broadly used because of their standout biological activity .…”

Section: Applications Of Anticoagulant Macromoleculesmentioning

confidence: 99%

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Anticoagulant Macromolecules

et al. 2023

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Anticoagulant macromolecules have gained widespread use in the clinical treatment of cardiovascular diseases, blood-contacting or implantable materials, and medical devices due to their excellent anticoagulant properties. Inspired by the molecular characteristics of physiological anticoagulants that play a vital role in normal human coagulation and anticoagulation mechanisms, diverse anticoagulant macromolecules with special molecular structures and functional groups have been developed, where they can be systematically applied to the biomedical field. In this Perspective, the history and the recent progress of synthetic methods for anticoagulant macromolecules obtained by purification of natural products, semisynthetic methods, and synthetic methods are discussed from the aspect of molecular design. The critical application and immense development potential of these anticoagulant macromolecules in the field of clinical treatment and biomedicine is proposed.

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Section: Medical Devices Based On Anticoagulant Macromoleculesmentioning

confidence: 99%

Section: Applications Of Anticoagulant Macromoleculesmentioning

confidence: 99%

Anticoagulant Macromolecules

et al. 2023

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“…After the implantation, the rabbits were treated with anticoagulant solution (heparin solution, 100 IU kg −1 ) for 3 d to avoid acute thrombus. [51] The rabbits were fed continuously without any systemic anticoagulation for one month to determine the influence of the different grafts on patency and articular regeneration. Blood flow changes in the arteries of all the rabbits were monitored with ultrasound after one and four weeks postsurgery to assess patency.…”

Section: Vascular Regeneration With the Composite Grafts In Vivomentioning

confidence: 99%

Biomimetic Vascular Grafts with Circumferentially and Axially Oriented Microporous Structures for Native Blood Vessel Regeneration

Ding,

Wang,

Chen

et al. 2023

Adv Funct Materials

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Porous grafts facilitate constructive remodeling of blood vessels. Incorporating multiple biomimetic cues to porous grafts can promote vascular regeneration. However, the fabrication of such medical devices remains challenging. Here, beta‐sheet rich silk nanofibers (BSN) are added to poly(vinyl alcohol) (PVA) solution and aggregated under a cylindric electric field to form circumferentially and axially oriented tubular structures, to simulate the endothelial and media layers of blood vessels. PVA in the aligned tubes is then crystallized through repeat freezing–thawing process to offer mechanical performances. Through tuning the ratio of BSN and PVA, the composite tubes with dual anisotropic microstructures exhibit better mechanical properties than pure PVA vascular grafts. Significantly improved cell adhesion, spreading, proliferation, and alignment are achieved. Both endothelial and smooth muscle cells show improved biological activity on the grafts due to the regulatory roles of the aligned structures. In vivo studies reveal the formation of endothelial layers within four weeks of implantation, ensuring long‐term patency. The endothelial and smooth muscle double layers are regenerated after eight months postimplantation, forming hierarchical microstructures and compositions similar to native vessels. The porous composite grafts with multiple aligned structures guide vascular remodeling to regenerate blood vessels, demonstrating potential for clinical translation.

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“…PU is often studied in combination with bio-derived materials described later, because PU reflects the design of the structure of the crystal domain based on chemical formulas and it is easy to control its biodegradability and mechanical properties. [ 12 , 16 ].…”

Section: Materials Used In Tevg Designmentioning

confidence: 99%

Clinical Application for Tissue Engineering Focused on Materials

et al. 2022

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Cardiovascular-related medical conditions remain a significant cause of death worldwide despite the advent of tissue engineering research more than half a century ago. Although autologous tissue is still the preferred treatment, donor tissue is limited, and there remains a need for tissue-engineered vascular grafts (TEVGs). The production of extensive vascular tissue (>1 cm3) in vitro meets the clinical needs of tissue grafts and biological research applications. The use of TEVGs in human patients remains limited due to issues related to thrombogenesis and stenosis. In addition to the advancement of simple manufacturing methods, the shift of attention to the combination of synthetic polymers and bio-derived materials and cell sources has enabled synergistic combinations of vascular tissue development. This review details the selection of biomaterials, cell sources and relevant clinical trials related to large diameter vascular grafts. Finally, we will discuss the remaining challenges in the tissue engineering field resulting from complex requirements by covering both basic and clinical research from the perspective of material design.

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Fabrication of heparinized small diameter TPU/PCL bi-layered artificial blood vessels and in vivo assessment in a rabbit carotid artery replacement model

Cited by 24 publications

References 46 publications

Anticoagulant Macromolecules

Anticoagulant Macromolecules

Biomimetic Vascular Grafts with Circumferentially and Axially Oriented Microporous Structures for Native Blood Vessel Regeneration

Clinical Application for Tissue Engineering Focused on Materials

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