In this research, using the response surface method (RSM), the effect of rotational speed, extrusion speed, and volume percentage of bioactive glass powder on the microstructure, mechanical properties, and corrosion resistance of AZ91-bioactive glass composite wire produced by friction stir-back extrusion has been studied. The results show that in hardness and strength responses, increasing the amount of bioactive glass from 1 to 5 vol.% increased the hardness and ultimate tensile strength by 18% and 13%, respectively. According to RSM prediction, the minimum corrosion rate (0.0427 ± 0.0059 mm/year), maximum ultimate tensile strength (327 ± 3 MPa), and maximum hardness (78.6 ± 2.1 HV) were achieved at rotational speed, extrusion speed, and bioactive glass particle content of 1200 rpm, 32.95 mm/min, and 5 vol.%, respectively.