2019
DOI: 10.1016/j.msec.2019.04.067
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Fabrication of hierarchically porous silk fibroin-bioactive glass composite scaffold via indirect 3D printing: Effect of particle size on physico-mechanical properties and in vitro cellular behavior

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Cited by 55 publications
(31 citation statements)
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“…Ideal scaffolds should possess a structure that mimics the structure of the host tissues in terms of porosity, mechanical, and biological properties to facilitate osteoinduction, vascularization, and tissue formation. In recent years, various strategies to achieve a better control of the micro and macro structural features of scaffolds have been developed ranging from the biphasic structure [138] to an indirect 3D printing technique [139]. The biphasic scaffolds were developed by an electrospinning technique and the two phases (i.e., bioactive glass and silk fibroin) preserved their own porous structure, resulting in good integration at the same time [138].…”
Section: Dip Coating Techniquementioning
confidence: 99%
“…Ideal scaffolds should possess a structure that mimics the structure of the host tissues in terms of porosity, mechanical, and biological properties to facilitate osteoinduction, vascularization, and tissue formation. In recent years, various strategies to achieve a better control of the micro and macro structural features of scaffolds have been developed ranging from the biphasic structure [138] to an indirect 3D printing technique [139]. The biphasic scaffolds were developed by an electrospinning technique and the two phases (i.e., bioactive glass and silk fibroin) preserved their own porous structure, resulting in good integration at the same time [138].…”
Section: Dip Coating Techniquementioning
confidence: 99%
“…The next important issue was to evaluate the initial cell attachment, spreading, proliferation, and differentiation of hMSCs on the modified copolymers. Cell attachment is influenced by several material properties, e.g., surface topography, surface charge, porosity, degradation, and the expression of cell surface molecules and their interaction with the material [10,13,14,21]. In this study, the modification did not lead to the expected enhancement of cell adhesion, and this might have been due to both the property of the cell's phenotype and its degree of hydrophilicity.…”
Section: Discussionmentioning
confidence: 60%
“…Due to the addition of PDA to the PU matrix, the contact angle was reduced by 18% in comparison with the PU material ( p < 0.05). Also, the incorporation of dECM reduced the contact angle by 12% compared to PU/PDA ( p < 0.05), and thus, the contact angle of PU/PDA/dECM group was in the range of contact angles for maximal cell adhesion [38]. These results indicated that the addition of PDA and ECM was able to enhance hydrophilicity as demarcated with a lower contact angle.…”
Section: Resultsmentioning
confidence: 99%