Fabrication of hyaluronic acid-inulin coated Enterococcus faecium for colon-targeted delivery to fight Fusobacterium nucleatum

Zhu, Pengrong; Meng, Lingtong; Shu, Yue; Xu, Yuqiao; Liu, Weiming; Bi, Yong; Xu, Jian; Meng, Lijuan; Li, Yanan

doi:10.1016/j.carbpol.2024.121797

Carbohydrate Polymers

2024

DOI: 10.1016/j.carbpol.2024.121797

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Fabrication of hyaluronic acid-inulin coated Enterococcus faecium for colon-targeted delivery to fight Fusobacterium nucleatum

Pengrong Zhu,

Lingtong Meng,

Yue Shu

et al.

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Ouyang,

Zhao,

et al. 2024

Small Methods

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Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications in disease treatment. HA possesses good biocompatibility, biodegradability, and the ability to interact with various cell surface receptors. Its wide range of molecular weights and modifiable chemical groups make it an effective drug carrier for drug delivery. Additionally, the overexpression of specific receptors for HA on cell surfaces in many disease states enhances the accumulation of drugs at pathological sites through receptor binding. In this review, the modification of HA with drugs, major receptor proteins, and the latest advances in receptor‐targeted nano drug delivery systems (DDS) for the treatment of tumors and inflammatory diseases are summarized. Furthermore, the functions of HA with varying molecular weights of HA in vivo and the selection of drug delivery methods for different diseases are discussed.

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Ouyang,

Zhao,

et al. 2024

Small Methods

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Engineered inulin-based hybrid biomaterials for augmented immunomodulatory responses

Jangid,

Noh,

Kim

et al. 2024

Carbohydrate Polymers

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Applications of polysaccharides in enzyme-triggered oral colon-specific drug delivery systems: A review

Gong,

Liu,

Wang

et al. 2024

International Journal of Biological Macromolecules

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Fabrication of hyaluronic acid-inulin coated Enterococcus faecium for colon-targeted delivery to fight Fusobacterium nucleatum

Cited by 5 publications

References 50 publications

Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Engineered inulin-based hybrid biomaterials for augmented immunomodulatory responses

Applications of polysaccharides in enzyme-triggered oral colon-specific drug delivery systems: A review

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