Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Abstract

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

Enhanced In Vitro Wound Healing Using PVA/B-PEI Nanofiber Mats: A Promising Wound Therapeutic Agent against ESKAPE and Opportunistic Pathogens

“…The initial phase of the study focused on developing NF mats of different weight percentages and was optimized by screening against microbes for potential antimicrobial activity. The synthesized fibers were characterized using SEM and FTIR and the tensile strength of B-PEI NF indicates a good enhancement in the mechanical property after the addition of PEI with PVA, which matches the typical range of mechanical strength suitable for wound dressing applications. , …”

“…The synthesized fibers were characterized using SEM and FTIR and the tensile strength of B-PEI NF indicates a good enhancement in the mechanical property after the addition of PEI with PVA, which matches the typical range of mechanical strength suitable for wound dressing applications. 59,60 Assays have shown that B-PEI increases the permeability of the cell membranes. 61 Depolarization of the membrane potential is also considered a cell disruption mechanism of B-PEI.…”

Polymer-Based Wound Dressing Materials Loaded with Bioactive Agents: Potential Materials for the Treatment of Diabetic Wounds

“…Natural-based polymeric wound dressing materials are usually cross-linked with synthetic polymers to enhance their mechanical performance [14]. The synthetic polymers that can be cross-linked with natural polymers for wound dressing formulations include poly(vinyl alcohol) (PVA), poly(lactic-co-glycolic acid) (PLGA), polylactide (PLA), polyglycolic acid (PGA), polyurethanes (PUs), poly(ethylene oxide) (PEO)/poly(ethylene glycol) (PEG), poly(hydroxyethyl methacrylate) (PHEMA), and poly(vinyl pyrrolidone) (PVP) [15]. The cross-linked dressings can also exhibit poor biological activities and weak wound healing properties, making them inappropriate for managing diabetic wounds.…”

Polycaprolactone/Polyethylene Glycol Blended with Dipsacus asper Wall Extract Nanofibers Promote Osteogenic Differentiation of Periodontal Ligament Stem Cells

“…Electrospinning can form nanofibers that are much smaller than the size of cells and can also form porous structures, which are good for stimulating the growth of cells through environmental cues within the body. In 2002, Li et al proposed the advantages of electrostatic nanofiber technology for use at the level of tissue engineering [ 13 ], Yoshimoto et al further confirmed the great potential of electrostatic nanofibers as bone tissue engineering scaffolds [ 14 ], Alven and Aderibigbe reviewed the PVA/PCL hybrid nanofiber for wound dressing application [ 15 ].…”