Fabrication of hydrogel coatings by atmospheric-pressure plasma polymerization

Levien, Monique; Fricke, Katja

doi:10.1016/j.mattod.2020.10.020

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…Microstructuration based on surface instabilities fabricated by an atmospheric-pressure plasma jet has been reported recently [ 27 ]. Figure 2 shows the microscopic images of the hydrogel mixtures generated with the droplet method.…”

Section: Resultsmentioning

confidence: 99%

“…Conventionally, hydrogels are prepared via free radical polymerization, photochemical coupling, or 3D printing techniques, including several fabrication steps using chemical detergents for polymerization initiation or cross-linking [ 24 , 25 , 26 ]. Another approach for the fabrication of hydrogels is the use of atmospheric-pressure plasma polymerization, as described in our previous study [ 27 ]. This method is based on surface activation by argon (Ar) plasma, followed by the deposition of an acrylate-based monomer mixture in the liquid phase on the plasma-activated substrate and subsequent polymerization by atmospheric-pressure plasma.…”

Section: Introductionmentioning

confidence: 99%

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Study on the Interaction of Plasma-Polymerized Hydrogel Coatings with Aqueous Solutions of Different pH

Levien

Nasri

Weltmann

et al. 2023

Gels

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Amphiphilic hydrogels from mixtures of 2-hydroxyethyl methacrylate and 2-(diethylamino)ethyl methacrylate p(HEMA-co-DEAEMA) with specific pH sensitivity and hydrophilic/hydrophobic structures were designed and polymerized via plasma polymerization. The behavior of plasma-polymerized (pp) hydrogels containing different ratios of pH-sensitive DEAEMA segments was investigated concerning possible applications in bioanalytics. In this regard, the morphological changes, permeability, and stability of the hydrogels immersed in solutions of different pHs were studied. The physico-chemical properties of the pp hydrogel coatings were analyzed using X-ray photoelectron spectroscopy, surface free energy measurements, and atomic force microscopy. Wettability measurements showed an increased hydrophilicity of the pp hydrogels when stored in acidic buffers and a slightly hydrophobic behavior after immersion in alkaline solutions, indicating a pH-dependent behavior. Furthermore, the pp (p(HEMA-co-DEAEMA) (ppHD) hydrogels were deposited on gold electrodes and studied electrochemically to investigate the pH sensitivity of the hydrogels. The hydrogel coatings with a higher ratio of DEAEMA segments showed excellent pH responsiveness at the studied pHs (pH 4, 7, and 10), demonstrating the importance of the DEAEMA ratio in the functionality of pp hydrogel films. Due to their stability and pH-responsive properties, pp (p(HEMA-co-DEAEMA) hydrogels are conceivable candidates for functional and immobilization layers for biosensors.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study on the Interaction of Plasma-Polymerized Hydrogel Coatings with Aqueous Solutions of Different pH

Levien

Nasri

Weltmann

et al. 2023

Gels

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“…Plasma coatings that release antimicrobials in response to external stimuli are produced by 'sandwiching' of antimicrobials between two plasma polymer layers, plasma polymer over coating or nano-templating for creation of antimicrobial reservoirs [45][46][47]. A novel approach to generate hydrogel coatings through atmospheric-pressure plasma polymerization includes: plasma pre-treatment of the substrate leaving reactive surface radicals; plasma-induced polymerization of the monomer units and cross-linking the polymer chains into a polymer network [48].…”

Section: Deposition Of Antimicrobial Plasma Coatingsmentioning

confidence: 99%

Plasma Based Approaches for Deposition and Grafting of Antimicrobial Agents to Polymer Surfaces

Vladkova

Gospodinova

2022

Urinary Stents

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Improved protection of urinary stents against infections is a significant current challenge because of the increasing microbial resistance to the conventional antibiotics and negative issues for the patients. Formation of crystalline biofilms of pathogenic microbial cells is the leading cause of urinary stent associated infections. A lot of approaches, antimicrobial agents and techniques are under a study to mitigate the problem by creation of contact killing; releasing or low adhesive surfaces do not allow attachment of microbial cells. The plasma treatment has a number of advantages that make it preferable in many strategies for the development of antimicrobial biomaterials. The control over the plasma processing parameters allows control over the surface chemistry, charge, structure, morphology, hydrophilic/hydrophobic balance, etc. Due to a variety of biomaterials and bacteria, causing urinary tract infections, plasma assisted antibacterial strategies need in tailoring to each specific surface. Plasma treatment of polymers under corresponding operation conditions allows deposition of contact killing, releasing (including controlled release) or low-adhesive antimicrobial coatings, as well as polymer surface functionalization and durable immobilization of antimicrobial molecules. Most of the plasma technologies are developed in laboratory and the surface engineered biomaterials are tested in vitro.

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“…[ 33 , 41 , 42 , 43 ] We hypothesize that different types of hydrogels and different plasma processing methods may result in different physicochemical properties and functionalities of PAHs, which may further improve their biological benefits and applications through the as yet unknown physicochemical mechanisms. [ 44 , 45 , 46 , 47 ] And this cross‐sectional comparison of different types of hydrogels and their physicochemical properties after being activated by plasma which can be a reference for PAH methods is still lacking relatively well studied.…”

Section: Introductionmentioning

confidence: 99%

Plasma‐Activated Hydrogels for Microbial Disinfection

et al. 2023

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A continuous risk from microbial infections poses a major environmental and public health challenge. As an emerging strategy for inhibiting bacterial infections, plasma‐activated water (PAW) has proved to be highly effective, environmental‐friendly, and non‐drug resistant to a broad range of microorganisms. However, the relatively short lifetime of reactive oxygen and nitrogen species (RONS) and the high spreadability of liquid PAW inevitably limit its real‐life applications. In this study, plasma‐activated hydrogel (PAH) is developed to act as reactive species carrier that allow good storage and controlled slow‐release of RONS to achieve long‐term antibacterial effects. Three hydrogel materials, including hydroxyethyl cellulose (HEC), carbomer 940 (Carbomer), and acryloyldimethylammonium taurate/VP copolymer (AVC) are selected, and their antibacterial performances under different plasma activation conditions are investigated. It is shown that the composition of the gels plays the key role in determining their biochemical functions after the plasma activation. The antimicrobial performance of AVC is much better than that of PAW and the other two hydrogels, along with the excellent stability to maintain the antimicrobial activity for more than 14 days. The revealed mechanism of the antibacterial ability of the PAH identifies the unique combination of short‐lived species (1O2, ∙OH, ONOO− and O2−) stored in hydrogels. Overall, this study demonstrates the efficacy and reveals the mechanisms of the PAH as an effective and long‐term disinfectant capable of delivering and preserving antibacterial chemistries for biomedical applications.

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Fabrication of hydrogel coatings by atmospheric-pressure plasma polymerization

Cited by 7 publications

References 3 publications

Study on the Interaction of Plasma-Polymerized Hydrogel Coatings with Aqueous Solutions of Different pH

Study on the Interaction of Plasma-Polymerized Hydrogel Coatings with Aqueous Solutions of Different pH

Plasma Based Approaches for Deposition and Grafting of Antimicrobial Agents to Polymer Surfaces

Plasma‐Activated Hydrogels for Microbial Disinfection

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