Fabrication of Janus particles composed of poly (lactic-co-glycolic) acid and hard fat using a solvent evaporation method

Matsumoto, Akira; Murao, Satoshi; Matsumoto, Michiko; Watanabe, Chie; Murakami, Masahirô

doi:10.5582/ddt.2016.01230

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…Although methylene chloride is a good solvent for both ammonioalkyl methacrylate copolymer and triglycerides, phase separation was observed above a certain concentration, referred to as the critical concentration. The critical concentration between ammonioalkyl methacrylate copolymer and triglycerides was found to be higher than that between poly (lactideco-glycolide) and triglycerides in methylene chloride, as reported previously (28). In addition, at the critical concentration of the ammonioalkyl methacrylate copolymer/triglyceride/methylene chloride ternary system, the solution showed higher viscosity than that of the poly (lactide-co-glycolide)/triglyceride/methylene chloride ternary system.…”

Section: Discussionsupporting

confidence: 81%

“…In addition, at the critical concentration of the ammonioalkyl methacrylate copolymer/triglyceride/methylene chloride ternary system, the solution showed higher viscosity than that of the poly (lactide-co-glycolide)/triglyceride/methylene chloride ternary system. This is not only due to the higher critical concentration of the ammonioalkyl methacrylate copolymer/triglyceride/methylene chloride ternary system but also because the ammonioalkyl methacrylate copolymer (molecular weight: 32 kDa) used in this study has a higher molecular weight than the poly (lactide-coglycolide) used in the previous study (molecular weight: 20 kDa) (28). The higher viscosity is a notable point.…”

Section: Discussionmentioning

confidence: 74%

“…The phase separation method is based on a phenomenon in which phase separation occurs between two materials as the solvent is evaporated. We have previously reported that solvent evaporation following formation of an o/ w-type emulsion can yield Janus microspheres composed of poly (lactide-co-glycolide) and triglycerides (28). Phase separation between poly (lactide-co-glycolide) and triglycerides occurs in a dispersed oil droplet as the solvent is evaporated.…”

Section: Discussionmentioning

confidence: 99%

“…For mixtures of ammonioalkyl methacrylate copolymer and triglycerides, phase separation in the dispersed oil phase is believed to occur at higher viscosity than that for mixtures of poly (lactide-co-glycolide) and triglycerides in the process of solvent evaporation as reflected in the results of phase diagram analysis. In our previous study, we proposed a mechanism whereby Janus microspheres are formed: the droplets produced by phase separation in the dispersed oil phase of the emulsion aggregate and coalesce before the coalescing droplets migrate to form two layers, resulting in the formation of Janus microspheres (28). It is believed that obtaining a Janus conformation using mixtures of ammonioalkyl methacrylate copolymer and triglycerides is more difficult because high viscosity may prevent coalescence and migration of the separated droplets.…”

Section: Discussionmentioning

confidence: 99%

“…(DL-lactide-co-glycolide) and a hard fat (Suppocire AM) (28). We use fluorescein isothiocyanate-dextran with an average molecular weight of 3,000-5,000 Da (FD4) as a model drug because biomedicines such as polypeptides and nucleic acids are generally hydrophilic linear macromolecules.…”

Section: Determination Of Fd4 Contents In Janus Microspheresmentioning

confidence: 99%

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Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer

Matsumoto

Watanabe

Murakami

2019

DD&T

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Determination Of Fd4 Contents In Janus Microspheresmentioning

confidence: 99%

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Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer

Matsumoto

Watanabe

Murakami

2019

DD&T

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Janus particles: from concepts to environmentally friendly materials and sustainable applications

2020

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Janus particles represent a unique group of patchy particles combining two or more different physical or chemical functionalities at their opposite sides. Especially, individual Janus particles (JPs) with both chemical and geometrical anisotropy as well as their assembled layers provide considerable advantages over the conventional monofunctional particles or surfactant molecules offering (a) a high surface-to-volume ratio; (b) high interfacial activity; (c) target controlling and manipulation of their interfacial activity by external signals such as temperature, light, pH, or ionic strength and achieving switching between stable emulsions and macro-phase separation; (d) recovery and recycling; (e) controlling the mass transport across the interface between the two phases; and finally (f) tunable several functionalities in one particle allowing their use either as carrier materials for immobilized catalytically active substances or, alternatively, their site-selective attachment to substrates keeping another functionality active for further reactions. All these advantages of JPs make them exclusive materials for application in (bio-)catalysis and (bio-)sensing. Considering "green chemistry" aspects covering biogenic materials based on either natural or fully synthetic biocompatible and biodegradable polymers for the design of JPs may solve the problem of toxicity of some existing materials and open new paths for the development of more environmentally friendly and sustainable materials in the very near future. Considering the number of contributions published each year on the topic of Janus particles in general, the number of contributions regarding their environmentally friendly and sustainable applications is by far smaller. This certainly pinpoints an important challenge and is addressed in this review article. The first part of the review focuses on the synthesis of sustainable biogenic or biocompatible Janus particles, as well as strategies for their recovery, recycling, and reusability. The second part addresses recent advances in applications of biogenic/biocompatible and non-biocompatible JPs in environmental and biotechnological fields such as sensing of hazardous pollutants, water decontamination, and hydrogen production. Finally, we provide implications for the rational design of environmentally friendly and sustainable materials based on Janus particles.

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Customizing poly(lactic-co-glycolic acid) particles for biomedical applications

et al. 2018

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Nanoparticles are increasingly important in the field of biomedicine. Particles made of polymers are in the spotlight, due to their biodegradability, biocompatibility, versatility. In this review, we aim to discuss the range of formulation techniques, manipulations, and applications of poly(lactic-co-glycolic acid) (PLGA) particles, to enable a researcher to effectively select or design the optimal particles for their application. We describe the various techniques of PLGA particle synthesis and their impact on possible applications. We focus on recent developments in the field of PLGA particles, and new synthesis techniques that have emerged over the past years. Overall, we show how the chemistry of PLGA particles can be adapted to solve pressing biological needs.

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Fabrication of Janus particles composed of poly (lactic-co-glycolic) acid and hard fat using a solvent evaporation method

Cited by 5 publications

References 25 publications

Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer

Janus microspheres for enhanced enteral drug delivery: Preparation and orientated attachment to a Caco-2 monolayer

Janus particles: from concepts to environmentally friendly materials and sustainable applications

Customizing poly(lactic-co-glycolic acid) particles for biomedical applications

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