Fabrication of large-scale gold nanoplate films as highly active SERS substrates for label-free DNA detection

Bi, Liyan; Rao, Yanying; Qin, Tao; Dong, Jian; Su, Ting; Liu, Fang-Jing; Qian, Weiping

doi:10.1016/j.bios.2012.11.029

Cited by 71 publications

(33 citation statements)

References 63 publications

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“…Because of the combination of AuNPs and graphene, the Raman signals of dyes were dramatically enhanced by this substrate, and a detection limit as low as 10 pM was obtained. Moreover, SERS active substrates composed of Different shaped AuNPs including boot-shaped gold nanoparticles, 249 gold nanoflowers, 250 and gold nanoplates 251 have also been investigated for SERS-based biodetection.…”

Section: Aunp-based Sers Assaysmentioning

confidence: 99%

Gold Nanoparticles for In Vitro Diagnostics

et al. 2015

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Section: Aunp-based Sers Assaysmentioning

confidence: 99%

Gold Nanoparticles for In Vitro Diagnostics

et al. 2015

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“…This permitted a quantitative analysis of the relative numbers of nucleobases in the DNA strands. Large-scale gold nanoplate (GNP) films presented by Bi and co-workers are an interesting platform for label-free detection [56]. Authors have presented rapid and simple methods of their preparation and have tested this surface with SERS measurements of DNA bases.…”

Section: Label-free Sensorsmentioning

confidence: 99%

Surface Enhanced Raman Spectroscopy for DNA Biosensors—How Far Are We?

et al. 2019

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A sensitive and accurate identification of specific DNA fragments (usually containing a mutation) can influence clinical decisions. Standard methods routinely used for this type of detection are PCR (Polymerase Chain Reaction, and its modifications), and, less commonly, NGS (Next Generation Sequencing). However, these methods are quite complicated, requiring time-consuming, multi-stage sample preparation, and specially trained staff. Usually, it takes weeks for patients to obtain their results. Therefore, different DNA sensors are being intensively developed by many groups. One technique often used to obtain an analytical signal from DNA sensors is Raman spectroscopy. Its modification, surface-enhanced Raman spectroscopy (SERS), is especially useful for practical analytical applications due to its extra low limit of detection. SERS takes advantage of the strong increase in the efficiency of Raman signal generation caused by a local electric field enhancement near plasmonic (typically gold and silver) nanostructures. In this condensed review, we describe the most important types of SERS-based nanosensors for genetic studies and comment on their potential for becoming diagnostic tools.

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“…This enhancement is inherently dependent on the size/shape of Au nanocrystals and could be finely tailored, being capable of employing for ultrasensitive chemical analysis and single molecular detection . For example, an tremendous enhancement factor (higher than 1.0 × 10 7 ) of surface‐enhanced Raman scattering (SERS) activities were achieved with Au nanoplates as SERS substrates . The Raman scattering intensity could be further enhanced when combining SERS with scanning probe microscopy (i.e tip‐enhanced Raman spectroscopy, TERS), where LSPRs are excited between an illumined tip and Au substrates and produce a tremendous increase of electromagnetic field .…”

Section: Applications Of 2d Au Nanocrystalsmentioning

confidence: 99%

Two-Dimensional Au Nanocrystals: Shape/Size Controlling Synthesis, Morphologies, and Applications

Zhou

Kong

et al. 2015

Part. Part. Syst. Charact.

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796 wileyonlinelibrary.com www.particle-journal.com www.MaterialsViews.com REVIEWThe fascinating roles of two-dimensional (2D) nanomaterials in natural superstrong bio-composites (i.e. aragonite platelets in nacre and apatite platelets in bone) have aroused great interest in scientifi c communities to synthesize their artifi cial counterparts with controllable geometric and physical properties. The quantum 2D confi nement of electrons recently revealed in graphene nanosheets further inspires to explore 2D metal nanocrystals with intrinsic anisotropic properties and quantum size effect. Among them, 2D Au nanocrystals stand out not only due to their unique structure-and environmental-dependent properties, but also due to their rapid development in synthesis approaches and emerging applications in electronics, optics, sensing and biomedicines. In this Review the aim is to rationalize numerous newly published studies on 2D Au nanocrystals and to gain insight into their shape/ size controlling synthesis, diverse morphologies, properties, and applications, potentially serving a handy guide to achieve on-demand 2D Au nanocrystals.

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Fabrication of large-scale gold nanoplate films as highly active SERS substrates for label-free DNA detection

Cited by 71 publications

References 63 publications

Gold Nanoparticles for In Vitro Diagnostics

Gold Nanoparticles for In Vitro Diagnostics

Surface Enhanced Raman Spectroscopy for DNA Biosensors—How Far Are We?

Two-Dimensional Au Nanocrystals: Shape/Size Controlling Synthesis, Morphologies, and Applications

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