Polymer-based nano-delivery systems do not conform to the toxicity standards and efficacy needed to act inside cells. Biopolymeric nanoparticles have biodegradability, compatibility with biological systems, and negligible toxicity, creating an edge over toxic polymers or metal nanoparticles. Besides being nanoparticles, they are naturally antibacterial and eco-friendly. Food-based matrices such as proteins and polysaccharides and complexes such as protein-polysaccharide complex and lipid-biopolymer hybrids are typically used to manufacture these nanoparticles. Manufacturing methods like nanoprecipitation, ionic gelation, microemulsion, and coacervation are discussed in this context. They are proven effective as food additives, vehicles for nutrient retention, packaging matrices, and functional food formulations. For wider application of this tool, testing in different systems to develop safe, effective, and degradable nano-delivery vehicles must be undertaken.