Fabrication of magnetite-based core–shell coated nanoparticles with antibacterial properties

Grumezescu, Valentina; Cristescu, R.; Chifiriuc, Mariana Carmen; Dorcioman, G.; Socol, G.; Mihăilescu, I. N.; Mihăiescu, Dan Eduard; Ficai, Anton; Vasile, Otilia Ruxandra; Enculescu, Monica; Chrisey, Douglas B.

doi:10.1088/1758-5090/7/1/015014

Cited by 28 publications

(14 citation statements)

References 57 publications

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“…Functionalized Fe 3 O 4 nanoparticles are usually prepared by wet chemical precipitation from aqueous iron salt solutions by means of alkaline media, like HO − and NH 3 [ 71 , 72 ]. In this case, the AN-extract-functionalized Fe 3 O 4 NPs were synthesized according to previously reported work [ 73 , 74 ] as follows: First, 500 mg of AN extract and 8 mL of NH 4 OH (25%) were added to 200 mL deionized water under stirring. Then, 1 g of FeCl 3 (anhydrous) and 1.6 g of FeSO 4 ·7H 2 O were dissolved in 200 mL of deionized water, and Fe +3 /Fe 2+ solution was dropped into the basic solution of AN extract.…”

Section: Methodsmentioning

confidence: 99%

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Neguț

Grumezescu

et al. 2020

Molecules

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Plant extracts are highly valuable pharmaceutical complexes recognized for their biological properties, including antibacterial, antifungal, antiviral, antioxidant, anticancer, and anti-inflammatory properties. However, their use is limited by their low water solubility and physicochemical stability. In order to overcome these limitations, we aimed to develop nanostructured carriers as delivery systems for plant extracts; in particular, we selected the extract of Anthriscus sylvestris (AN) on the basis of its antimicrobial effect and antitumor activity. In this study, AN-extract-functionalized magnetite (Fe3O4@AN) nanoparticles (NPs) were prepared by the co-precipitation method. The purpose of this study was to synthesize and investigate the physicochemical and biological features of composite coatings based on Fe3O4@AN NPs obtained by matrix-assisted pulsed laser evaporation technique. In this respect, laser fluence and drop-casting studies on coatings were performed. The physical and chemical properties of laser-synthesized coatings were investigated by scanning electron microscopy, while Fourier transform infrared spectroscopy comparative analysis was used for determining the chemical structure and functional integrity. Relevant data regarding the presence of magnetic nanoparticles as the only crystalline phase and the size of nanoparticles were obtained by transmission electron microscopy. The in vitro toxicity assessment of the Fe3O4@AN showed significant cytotoxic activity against human adenocarcinoma HT-29 cells after prolonged exposure. Antimicrobial results demonstrated that Fe3O4@AN coatings inhibit microbial colonization and biofilm formation in clinically relevant bacteria species and yeasts. Such coatings are useful, natural, and multifunctional solutions for the development of tailored medical devices and surfaces.

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Section: Methodsmentioning

confidence: 99%

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Neguț

Grumezescu

et al. 2020

Molecules

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“…The evaluation of the literature on Fe 3 O 4 activity in relation to S. aureus showed a variety of methodologies and results. 14,16,19,20,65,66 In our work, the broth microdilution method using UV 67 was initially tested, however, the results were not reproducible. Alternatively, the use of the agar dilution method 39 proved to be more reliable and reproducible.…”

Section: Characterization Of Liposomesmentioning

confidence: 92%

Preparation of Magnetoliposomes with a Green, Low-Cost, Fast and Scalable Methodology and Activity Study against S. aureus and C. freundii Bacterial Strains

Silva

Lara

López

et al. 2018

J. Braz. Chem. Soc.

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A novel, fast, low-cost and scalable methodology to prepare stable magnetoliposomes (MGLs), without the use of organic solvents, is described. The concept of the work is based on the dual use of soy lecithin associated to a new liposome preparation methodology. Soy lecithin was used to coat the nanoparticles of magnetite (Fe 3 O 4 @lecithin) and for encapsulation of Fe 3 O 4 @lecithin (Lip-Fe 3 O 4 @lecithin). Liposomes with size less than 160 nm, polydispersity index of 0.25 and zeta potential of-41 mV, were prepared with the use of autoclave and sonication. The liposomal formulations containing magnetite and stigmasterol (Lip-Fe 3 O 4 @lecithin, Lip-Stigma and Lip-Stigma-Fe 3 O 4 @lecithin) were shown to be promising for the application as antibacterial. The liposomal formulation and magnetite were characterized by the following techniques: conventional and high-resolution transmission electron microscopy (TEM/HRTEM), energy-filtered transmission electron microscopy (EFTEM), proton nuclear magnetic resonance (1 H NMR), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), dynamic light scattering (DLS) and zeta potential. The Lip-Fe 3 O 4 @lecithin had a minimum inhibitory concentration (MIC) of 8.4 μg mL-1 in the presence of 200 Oe magnetic field against S. aureus.

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“…Several components may constitute the functionalized outer coating depending particularly on the intended application. For example, diverse biological molecules [insulin, nerve growth factor (NGF), ceruloplasmin, elastin, Tat-peptide, folic acid, transferring, lactoferrin, transforming growth factor α (TGF-α), gluthatione (GSH), methotrexate, antibiotics, essential oils, and ascorbic acid, among many others] can be bound to the coating polymer in order to direct them to specific targets [ 11 , 12 , 14 , 21 , 91 , 126 , 127 , 128 , 129 ]. In the cases where it is intended to deliver drugs in specific targets or to make easier the degradation of the nanostructure, the non-specific physical sorption is preferred between the magnetite nanoparticles and the surface-modifying molecule, although non-covalent or covalent bindings may also occur [ 130 ].…”

Section: Superparamagnetic Iron Oxide Nanoparticles Applicationsmentioning

confidence: 99%

“…This result may mean that the therapeutic dose of amoxicillin can be reduced if under functionalized magnetite nanostructures [ 142 ]. The same research team [ 126 ] also reported a prolonged anti-biofilm activity against S. aureus and Pseudomonas aeruginosa in the presence of magnetite nanoparticles stabilized by sodium lauryl sulfate and coated with cefotaxime and cefrom antibiotics.…”

Section: Superparamagnetic Iron Oxide Nanoparticles Applicationsmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles and Essential Oils: A New Tool for Biological Applications

Miguel

Lourenço

Faleiro

2020

IJMS

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Essential oils are complex mixtures of volatile compounds with diverse biological properties. Antimicrobial activity has been attributed to the essential oils as well as their capacity to prevent pathogenic microorganisms from forming biofilms. The search of compounds or methodologies with this capacity is of great importance due to the fact that the adherence of these pathogenic microorganisms to surfaces largely contributes to antibiotic resistance. Superparamagnetic iron oxide nanoparticles have been assayed for diverse biomedical applications due to their biocompatibility and low toxicity. Several methods have been developed in order to obtain functionalized magnetite nanoparticles with adequate size, shape, size distribution, surface, and magnetic properties for medical applications. Essential oils have been evaluated as modifiers of the surface magnetite nanoparticles for improving their stabilization but particularly to prevent the growth of microorganisms. This review aims to provide an overview on the current knowledge about the use of superparamagnetic iron oxide nanoparticles and essential oils on the prevention of microbial adherence and consequent biofilm formation with the goal of being applied on the surface of medical devices. Some limitations found in the studies are discussed.

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Fabrication of magnetite-based core–shell coated nanoparticles with antibacterial properties

Cited by 28 publications

References 57 publications

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Nanostructured Thin Coatings Containing Anthriscus sylvestris Extract with Dual Bioactivity

Preparation of Magnetoliposomes with a Green, Low-Cost, Fast and Scalable Methodology and Activity Study against S. aureus and C. freundii Bacterial Strains

Superparamagnetic Iron Oxide Nanoparticles and Essential Oils: A New Tool for Biological Applications

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