Fabrication of Micro/Nanoscale Motors

Hong, Wang; Pumera, Martin

doi:10.1021/acs.chemrev.5b00047

Cited by 651 publications

(528 citation statements)

References 257 publications

(613 reference statements)

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“…The FSFSMs are not subject to the significant speed loss experienced by hybrid sperm motors guided by magnetic structures, and offer considerable advantages such as improved biocompatibility and simple fabrication process. [24,29] The concept of guiding and transporting synthetic nanoscale payloads via the intrinsic chemotactic movement of natural sperm carriers could pave the way for the development of smart and environmentally responsive micro/nanoscale vehicles that can autonomously navigate along chemical gradients.…”

Section: Doi: 101002/adbi201700160mentioning

confidence: 99%

Chemotactic Guidance of Synthetic Organic/Inorganic Payloads Functionalized Sperm Micromotors

et al. 2017

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The preparation and operation of free swimming functionalized sperm micromotors (FSFSMs) as intelligent self‐guided biomotors with intrinsic chemotactic motile behavior are reported. The natural sperm biomotors are functionalized with a wide variety of synthetic nanoscale payloads, such as CdSe/ZnS quantum dots, doxorubicin hydrochloride drug coated iron‐oxide nanoparticles, and fluorescein isothiocyanate‐modified Pt nanoparticles via endocytosis. The FSFSMs display efficient self‐propulsion in various biological and environmental media with controllable swarming behavior upon exposure to a chemical attractant. As a new class of environmentally responsive smart biomotors, the control of the FSFSM speed is achieved by varying the solution osmolarity that leads to different flagellar lengths. High drug loading capacity and responsive release kinetics are obtained with such sperm biomotors. The transport of synthetic cargo can be guided by the intrinsic chemotaxis of the FSFSMs. The chemotactic characteristics, speed control mechanism, and responsive payload release of the FSFSMs are investigated. Such use of free swimming functionalized sperm cells as intelligent microscale biomotors offers considerable potential for diverse biomedical and environmental applications.

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Section: Doi: 101002/adbi201700160mentioning

confidence: 99%

Chemotactic Guidance of Synthetic Organic/Inorganic Payloads Functionalized Sperm Micromotors

et al. 2017

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“…A solution mixture of 2.5 mM MUA and 7.5 mM MCH was prepared in ethanol. Aliquots of 100 µL were taken from the micromotor or microtube suspensions (containing 1.1×10 4 units, approximately), and after separation of the supernatant with centrifugation, the micromotors/microtubes were incubated in the MUA/MCH solution overnight. After washing the micromotors or microtubes with water for 5 min, they were transferred to an eppendorf vial containing a 100 µL MES buffer (pH 6.5) solution containing the coupling agents EDC and Sulfo-NHS at 0.4 and 0.1 M, respectively, and were incubated for 35 min.…”

Section: Micromotor Functionalizationmentioning

confidence: 99%

“…Particularly, the ability of nano/ microscale motors to capture and transport specific target analytes in complex biological matrixes has been extensively explored [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Rapid micromotor-based naked-eye immunoassay

Ávila

Zhao

Campuzano

et al. 2017

Talanta

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A B S T R A C TA dynamic micromotor-based immunoassay, exemplified by cortisol detection, based on the use of tubular micromotors functionalized with a specific antibody is described. The use of antibody-functionalized micromotors offers huge acceleration of both direct and competitive cortisol immunoassays, along with greatly enhanced sensitivity of direct and competitive immunoassays. The dramatically improved speed and sensitivity reflect the greatly increased likelihood of antibody-cortisol contacts and fluid mixing associated with the dynamic movement of these microtube motors and corresponding bubble generation that lead to a highly efficient and rapid recognition process. Rapid naked-eye detection of cortisol in the sample is achieved in connection to use of horseradish peroxidase (HRP) tag and TMB/H 2 O 2 system. Key parameters of the competitive immunoassay (e.g., incubation time and reaction volume) were optimized. This fast visual micromotor-based sensing approach enables "on the move" specific detection of the target cortisol down to 0.1 μg mL −1 in just 2 min, using ultrasmall (50 µL) sample volumes.

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“…[1][2][3][4][5][6][7][8][9] Catalytic micro/nanomotors that convert chemical energy into mechanical motions, are one of the most widely exploited autonomous nanomotors. [10][11][12][13][14][15][16][17][18] Billions of catalytic nanomotors can be facilely fabricated by using a variety of techniques, such as electrodeposition into nanoporous templates and electron beam deposition on monolayer nanospheres.…”

Section: Introductionmentioning

confidence: 99%

Electric-Field-Guided Precision Manipulation of Catalytic Nanomotors for Cargo Delivery and Powering Nanoelectromechanical Devices

et al. 2018

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ABSTRACT:We report a controllable and precision approach in manipulating catalytic nanomotors by strategically applied electric (E-) fields in three dimensions (3-D). With the high controllability, the catalytic nanomotors have demonstrated new versatility in capturing, delivering, and releasing of cargos to designated locations as well as in-situ integration with nanomechanical devices (NEMS) to chemically power the actuation. With combined AC and DC E-fields, catalytic nanomotors can be accurately aligned by the AC E-fields and instantly change their speeds by the DC E-fields. Within the 3-D orthogonal microelectrode sets, the in-plane transport of catalytic nanomotors can be swiftly turned on and off, and these catalytic nanomotors can also move in the vertical direction. The interplaying nanoforces that govern the propulsion and alignment are investigated. The modeling of catalytic nanomotors proposed in previous works has been confirmed quantitatively here. Finally, the prowess of the precision manipulation of catalytic nanomotors by E-fields is demonstrated in two applications: the capture, transport, and release of cargos to pre-patterned microdocks, and the assembly of catalytic nanomotors on NEMS to power the continuous rotation. The innovative concepts and approaches reported in this work could further advance ideal applications of catalytic nanomotors, e.g. for assembling and powering nanomachines, nanorobots, and complex NEMS devices.

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Fabrication of Micro/Nanoscale Motors

Cited by 651 publications

References 257 publications

Chemotactic Guidance of Synthetic Organic/Inorganic Payloads Functionalized Sperm Micromotors

Chemotactic Guidance of Synthetic Organic/Inorganic Payloads Functionalized Sperm Micromotors

Rapid micromotor-based naked-eye immunoassay

Electric-Field-Guided Precision Manipulation of Catalytic Nanomotors for Cargo Delivery and Powering Nanoelectromechanical Devices

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