Fabrication of micro-/submicro-/nanostructured surfaces on Ti–Zr alloy by varying H2SO4/H2O2 treatment conditions and investigations of fundamental properties of a typical surface

Zhao, Qian; Ueno, Takeshi; Chen, Peng; Nozaki, Kosuke; Tan, Tianbo; Hanawa, Takao; Wakabayashi, Noriyuki

doi:10.1016/j.surfin.2022.102390

Cited by 5 publications

(4 citation statements)

References 49 publications

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“…%Zr and Ti with H 2 SO 4 /H 2 O 2 to achieve micro/submicron/nano-structured surfaces and found that the MC3T3-E1 cell attachment level after 6 h and 24 h on Ti-30at. %Zr was superior to that of Ti [40] .…”

Section: Discussionmentioning

confidence: 83%

A review in titanium-zirconium binary alloy for use in dental implants: Is there an ideal Ti-Zr composing ratio?

Zhao

Ueno

Wakabayashi

2023

Japanese Dental Science Review

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Section: Discussionmentioning

confidence: 83%

A review in titanium-zirconium binary alloy for use in dental implants: Is there an ideal Ti-Zr composing ratio?

Zhao

Ueno

Wakabayashi

2023

Japanese Dental Science Review

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“…15 Zhao et al proposed that the water contact angle of the H 2 SO 4 /H 2 O 2treated Ti-45Zr group was significantly lower than that of the Ti group, which was attributed to the formation of the Ti-45Zr surface oxide films with TiO 2 and ZrO 2 as the main components, accompanied by the presence of a large number of hydroxyl groups. 65 In this study, according to the XPS analysis, an increase in the proportion of oxides such as TiO 2 , Nb 2 O 5 , ZrO 2 , and SnO 2 on the surface of the Ti2448 alloy under the OS microenvironment may improve the surface energy of the material and induce the formation of a more hydrophilic surface. 14,54,66 Hotchkiss et al 16 proposed that rougher and more hydrophilic surfaces are conducive to inducing macrophages to polarize toward the M2 phenotype, leading to an increased release of anti-inflammatory factors.…”

Section: Discussionmentioning

confidence: 78%

Corrosion and Biological Behaviors of Biomedical Ti–24Nb–4Zr–8Sn Alloy under an Oxidative Stress Microenvironment

Liu,

Yan,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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Biomaterials can induce an inflammatory response in surrounding tissues after implantation, generating and releasing reactive oxygen species (ROS), such as hydrogen peroxide (H 2 O 2 ). The excessive accumulation of ROS may create a microenvironment with high levels of oxidative stress (OS), which subsequently accelerates the degradation of the passive film on the surface of titanium (Ti) alloys and affects their biological activity. The immunomodulatory role of macrophages in biomaterial osteogenesis under OS is unknown. This study aimed to explore the corrosion behavior and bone formation of Ti implants under an OS microenvironment. In this study, the corrosion resistance and osteoinduction capabilities in normal and OS conditions of the Ti−24Nb−4Zr−8Sn (wt %, Ti2448) were assessed. Electrochemical impedance spectroscopy analysis indicated that the Ti2448 alloy exhibited superior corrosion resistance on exposure to excessive ROS compared to the Ti−6Al−4V (TC4) alloy. This can be attributed to the formation of the TiO 2 and Nb 2 O 5 passive films, which mitigated the adverse effects of OS. In vitro MC3T3-E1 cell experiments revealed that the Ti2448 alloy exhibited good biocompatibility in the OS microenvironment, whereas the osteogenic differentiation level was comparable to that of the TC4 alloy. The Ti2448 alloy significantly alleviates intercellular ROS levels, inducing a higher proportion of M2 phenotypes (52.7%) under OS. Ti2448 alloy significantly promoted the expression of the antiinflammatory cytokine, interleukin 10 (IL-10), and osteoblast-related cytokines, bone morphogenetic protein 2 (BMP-2), which relatively increased by 26.9 and 31.4%, respectively, compared to TC4 alloy. The Ti2448 alloy provides a favorable osteoimmune environment and significantly promotes the proliferation and differentiation of osteoblasts in vitro compared to the TC4 alloy. Ultimately, the Ti2448 alloy demonstrated excellent corrosion resistance and immunomodulatory properties in an OS microenvironment, providing valuable insights into potential clinical applications as implants to repair bone tissue defects.

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“…However, the role of surface roughness remains difficult to understand owing to varying surface topographies and/or chemical compositions across different studies. For instance, one report has suggested that nano-scale surface roughness on Ti surfaces does not influence cell attachment [22,38], whereas, other researchers have reported that micro-, and nano-hybrid roughness improve the cellular function [19,25,27]. The differences in cell adhesion behaviour between titanium and CCM suggest reduced osseointegration capacity of CCM than titanium implants.…”

Section: Comparative Analysis With Titanium and Implications For Ccm ...mentioning

confidence: 99%

“…This is a crucial property that determines the bonding between the implant and surrounding bone tissue to prevent peri-implantitis caused by bacterial infection or inflammation [16][17][18]. Surface roughness has been extensively studied for titanium implants, and various methods have been employed to optimise surface properties, resulting in improved implant performance [19][20][21][22][23][24][25][26][27][28][29][30]. However, similar investigations on the optimisation of surface roughness of CCM implants have been relatively limited.…”

Section: Introductionmentioning

confidence: 99%

Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys

Migita

2023

Biosurface and Biotribology

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Co‐Cr‐Mo ally (CCM) is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion resistance. However, the influence of surface roughness on cell attachment and proliferation remains unclear. This study aimed to elucidate the impact of surface roughness of CCM on the attachment and proliferation of osteoblasts. CCM samples with different values of surface rouges were prepared by polishing. MC3T3‐E1 mouse osteoblasts were used for cell culture experiments. Cell attachment, morphology, and the expression of actin stress fibres, vinculin, and distribution of yes‐associated protein were analysed. Our results suggest that surface roughness does not significantly affect cell attachment and proliferation on CCM, unlike on titanium. Thus implies that other properties of CCM, such as physicochemical properties, may play a more substantial role in modulating cell behaviour. This study provides important insights into the design of CCM implants, suggesting that approaches beyond tuning surface roughness may be necessary to improve biocompatibility and osseointegration.

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Fabrication of micro-/submicro-/nanostructured surfaces on Ti–Zr alloy by varying H2SO4/H2O2 treatment conditions and investigations of fundamental properties of a typical surface

Cited by 5 publications

References 49 publications

A review in titanium-zirconium binary alloy for use in dental implants: Is there an ideal Ti-Zr composing ratio?

A review in titanium-zirconium binary alloy for use in dental implants: Is there an ideal Ti-Zr composing ratio?

Corrosion and Biological Behaviors of Biomedical Ti–24Nb–4Zr–8Sn Alloy under an Oxidative Stress Microenvironment

Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys

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