Fabrication of microchannels on transparent PMMA using CO2 Laser (10.6 μm) for microfluidic applications: An experimental investigation

Prakash, Shashi; Kumar, Shailesh

doi:10.1007/s12541-015-0047-8

Cited by 97 publications

(35 citation statements)

References 13 publications

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“…Accordingly, the microchannel roughness is similar to that shown in Figure 10a. Figure 11 is the cross-section of a rectangle microchannel, and Figure 12 shows a 30 μm width rectangle microchannel whose size is commensurate with that achieved by some photolithography or laser introduced technologies [36,37]. Moreover, a 30 μm width rectangle microchannel is the smallest obtained during our study.…”

Section: Effect Of Thermal Engraving Velocity and Temperature On Rougsupporting

confidence: 76%

A Non-Photolithography Fabrication for a Microfluidic Chip Based on PMMA Polymer

Han

Liu

et al. 2015

Machines

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Polymer microchannels can be commonly processed using many non-lithographic methods for reducing the manufacturing cost and steps. In this research, an inexpensive and high-precision thermal engraving technology is developed and achieved to machine polymer microchannels ranging from tens to hundreds of micrometers. This paper presents the design of a thermal engraving device, the processing method and the experimental procedure. Thermal engraving microscribers can fabricate microchannels with a width less than 100 μm. Furthermore, the effects of velocity and temperature on the roughness of polymethyl methacrylate (PMMA) microchannels are also discussed. Finally, a smooth microchannel with these parameters optimally coordinated is achieved. Meanwhile, the contact angle (CA) and the electro-osmotic flow (EOF) of microchannels fabricated by this technology are also measured. The experimental results show that this method of fabrication has the advantages of low cost, high efficiency and small polymer microchannel size compared with several non-lithographic methods. This method of fabrication would be attractive for labs lacking extremely clean rooms and expensive photolithography apparatuses.

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Section: Effect Of Thermal Engraving Velocity and Temperature On Rougsupporting

confidence: 76%

A Non-Photolithography Fabrication for a Microfluidic Chip Based on PMMA Polymer

Han

Liu

et al. 2015

Machines

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“…Very less study is done on fabrication of micro-channels in hard-to-machine materials like titanium and nickel alloys. The fabrication of micro-channels in non-metallic can be found in various studies showing micro-channels produced in Polycarbonate (PC) [240], polymethyl methacrylate (PMMA) [241], Polydimethylsiloxane (PDMS) [242] and boro-aluminosilicate glass [243].…”

Section: Micro-channel Materialsmentioning

confidence: 99%

Laser Beam Machining, Laser Beam Hybrid Machining, and Micro-channels Applications and Fabrication Techniques

Darwish

Ahmed

Al‐Ahmari

2016

Advanced Structured Materials

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Laser beam machining (LBM) has proven its applications and advantages over almost all the range of engineering materials. It offers its competences from macro machining to micro and nano-machining of simple-to-complex shapes. The flipside of LBM is the existence of universal problems associated with its thermal ablation mechanism. In order to alleviate or reduce the inherent problems of LBM, a massive research has been done during the past decade and in turn build a relatively new route of laser-hybrid processes. The hybrid approaches in laser ablation have demonstrated much improved results in terms of material removal rate, surface integrity, geometrical tolerances, thermal damage, metallurgical alterations and many more. This chapter reviews the research work carried out so far in the area of LBM and its hybrid processes for different materials and shapes.

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“…Engraving of glass substrates by femtosecond laser can eliminate the use of cleanroom environments as well as the need for masks and molds during the fabrication, but standard instruments are expensive and not commonly found in chemical laboratories . On the contrary, standard‐grade CO 2 laser engraving has proven suitable for prototyping microfluidic devices in a variety of materials, including PDMS , PMMA , and paper . Due to the low thermal conductivity and significant coefficient of thermal expansion of common soda lime glass, fabrication of microfluidic devices by laser engraving often leads to cracking and/or a poor channel quality.…”

mentioning

confidence: 99%

Fast production of microfluidic devices by CO₂ laser engraving of wax‐coated glass slides

et al. 2016

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Glass is one of the most convenient materials for the development of microfluidic devices. However, most fabrication protocols require long processing times and expensive facilities. As a convenient alternative, polymeric materials have been extensively used due their lower cost and versatility. Although CO2 laser ablation has been used for fast prototyping on polymeric materials, it cannot be applied to glass devices because the local heating causes thermal stress and results in extensive cracking. A few papers have shown the ablation of channels or thin holes (used as reservoirs) on glass but the process is still far away from yielding functional glass microfluidic devices. To address these shortcomings, this communication describes a simple method to engrave glass-based capillary electrophoresis devices using standard (1 mm-thick) microscope glass slides. The process uses a sacrificial layer of wax as heat sink and enables the development of both channels (with semicircular shape) and pass-through reservoirs. Although microscope images showed some small cracks around the channels (that became irrelevant after sealing the engraved glass layer to PDMS) the proposed strategy is a leap forward in the application of the technology to glass. In order to demonstrate the capabilities of the approach, the separation of dopamine, catechol and uric acid was accomplished in less than 100 s.

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Fabrication of microchannels on transparent PMMA using CO2 Laser (10.6 μm) for microfluidic applications: An experimental investigation

Cited by 97 publications

References 13 publications

A Non-Photolithography Fabrication for a Microfluidic Chip Based on PMMA Polymer

A Non-Photolithography Fabrication for a Microfluidic Chip Based on PMMA Polymer

Laser Beam Machining, Laser Beam Hybrid Machining, and Micro-channels Applications and Fabrication Techniques

Fast production of microfluidic devices by CO₂ laser engraving of wax‐coated glass slides

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Fabrication of microchannels on transparent PMMA using CO2 Laser (10.6 μm) for microfluidic applications: An experimental investigation

Cited by 97 publications

References 13 publications

A Non-Photolithography Fabrication for a Microfluidic Chip Based on PMMA Polymer

A Non-Photolithography Fabrication for a Microfluidic Chip Based on PMMA Polymer

Laser Beam Machining, Laser Beam Hybrid Machining, and Micro-channels Applications and Fabrication Techniques

Fast production of microfluidic devices by CO2 laser engraving of wax‐coated glass slides

Contact Info

Product

Resources

About

Fast production of microfluidic devices by CO₂ laser engraving of wax‐coated glass slides