Fabrication of Mn²⁺-Doped Hollow Mesoporous Aluminosilica Nanoparticles for Magnetic Resonance Imaging and Drug Delivery for Therapy of Colorectal Cancer

Abstract

A novel Mn2+-doped hollow Mn-HMAS aluminosilica (Mn-HMAS) nanoparticle for simultaneous T1-weighted magnetic resonance imaging and drug delivery was reported. The magnetic resonance tests showed that the Mn-HMAS nanoparticles display an excellent T1-weighted magnetic resonance imaging effect with a high T1 relaxivity (r1) of 8.8 mM-1S-1. The MTT assays showed that the Mn-HMAS-DOX nanoparticles possess a better tumour cell inhibition effect than DOX. In addition, the Mn-HMAS nanoparticles also exhibit good stability and noncytotoxicity. These results demonstrated that the Mn-HMAS nanoparticles can be applied for the loading and delivery of various drugs in medicine.

Current status of Fe-based MOFs in biomedical applications

“…81–83 Depending on the MRI type, the two CA categories are T 1 and T 2 . 84 By shortening the longitudinal relaxation time of protons of water in T 1 CAs, the tumor site will appear brighter, 80,85–90 whereas a dark signal will appear in T 2 CAs, shortening their transverse relaxation time. 91–94 To date, paramagnetic Gd 3+ complexes are clinical T 1 representatives, 95–97 while superparamagnetic Fe-oxide (IO) NPs are T 2 CAs.…”

Iron-Based Hollow Nanoplatforms for Cancer Imaging and Theranostics

“…Based on the different types of MRI, the CAs can be divided into T 1 and T 2 two categories [ 26 ]. T 1 CAs shorten the longitudinal relaxation time of water protons and thus brighten the tumor sites [ 22 , 27 , 28 , 29 , 30 , 31 , 32 ], whereas T 2 CAs shorten the transverse relaxation time of water protons and produce dark signals [ 33 , 34 , 35 , 36 ]. Up to now, paramagnetic Gd(III) complexes [ 37 , 38 , 39 ] and superparamagnetic iron oxide (IO) nanoparticles (NPs) [ 40 , 41 , 42 ] are the representatives of clinical T 1 and T 2 CAs, respectively.…”