Fabrication of molecularly imprinted electrochemical sensors for sensitive codeine detection

Yence, Merve; Çetinkaya, Ahmet; Çorman, M. Emin; Uzun, Lokman; Çağlayan, Mehmet Gökhan; Ozkan, Sibel A.

doi:10.1016/j.microc.2023.109060

Cited by 9 publications

(1 citation statement)

References 39 publications

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“…This process aims to generate artificial antibodies, often called plastibodies, which exhibit molecular recognition capabilities in bioanalytical applications [10][11][12][13]. Although MIPs for low-molecular-weight substances like pharmaceuticals, narcotic drugs, amino acids, toxins, sugars, and pesticides have been successfully prepared, it is still challenging for biomacromolecules like proteins or viruses due to their structural complexity and fragility under MIP preparation conditions [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. However, increasing attention has been paid to the fabrication of MIPs due to their ease of preparation, cost-effectiveness, and stability under various conditions like extreme pHs, high temperatures, or organic solvents.…”

Section: Introductionmentioning

confidence: 99%

A Tale of Captopril Detection Based on an Electrochemical Mip Sensor

Yarman,

Kurbanoğlu

2024

Ankara Ecz. Fak. Derg.

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Objective: In this study, it was aimed to develop a voltammetric method using sensors prepared with the molecular imprinting technique for the detection of Captopril, an antihypertensive drug. Material and Method: With the molecular imprinting method, molecularly imprinted polymers were formed on the surfaces of glassy carbon electrodes. The analysis of Captopril was carried out using the differential pulse voltammetry method, and the performance of the sensor was examined. Result and Discussion: A linear analysis was performed up to 50 pM Captopril with a limit of detection value of 2.62 pM. Selectivity studies have shown that Captopril has a higher electrochemical response than other interfering substances, such as paracetamol, ascorbic acid, and L-proline.

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