Fabrication of monolithic 3D micro-systems

Preechaburana, Pakorn; Filippini, Daniel

doi:10.1039/c0lc00331j

Cited by 19 publications

(17 citation statements)

References 28 publications

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“…The lens supporting part of the LOC device was made from Dow Corning Sylgard 184 PDMS (polydimethylsiloxane [21]) with a base/curing agent ratio of 10:1, as negative replicas of a SU-8 (10) template (Microchem Corp., Newton, MA, USA) created with a refined micro projection lithography system (MPLS) described elsewhere [22]. The template created a 30 μm deep circular depression that confines the liquid lens.…”

Section: Methodsmentioning

confidence: 99%

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Embedded Adaptive Optics for Ubiquitous Lab-on-a-Chip Readout on Intact Cell Phones

Preechaburana

Suska

Filippini

2012

Sensors

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The evaluation of disposable lab-on-a-chip (LOC) devices on cell phones is an attractive alternative to migrate the analytical strength of LOC solutions to decentralized sensing applications. Imaging the micrometric detection areas of LOCs in contact with intact phone cameras is central to provide such capability. This work demonstrates a disposable and morphing liquid lens concept that can be integrated in LOC devices and refocuses micrometric features in the range necessary for LOC evaluation using diverse cell phone cameras. During natural evaporation, the lens focus varies adapting to different type of cameras. Standard software in the phone commands a time-lapse acquisition for best focal selection that is sufficient to capture and resolve, under ambient illumination, 50 μm features in regions larger than 500 × 500 μm2. In this way, the present concept introduces a generic solution compatible with the use of diverse and unmodified cell phone cameras to evaluate disposable LOC devices.

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Section: Methodsmentioning

confidence: 99%

“…The LOCs devices used for testing are 3D chambers created using a refined MPLS approach [22]. In order to make closed chambers with their own roof, the exposure depth of a SU-8/S1818 mixture is precisely controlled, as described in a previous work [22].…”

Section: Methodsmentioning

confidence: 99%

Embedded Adaptive Optics for Ubiquitous Lab-on-a-Chip Readout on Intact Cell Phones

Preechaburana

Suska

Filippini

2012

Sensors

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“…10 A photosensitive polymer formulation, SU-8 photoresist, was used for fast prototyping of monolithic 3D micro-systems by a mask-less micro-projection lithography platform. 11 Plastics overcome some limitations of PDMS, but their relatively complex fabrication still presents a bottleneck for widespread use for prototyping in academic laboratories. Relative to PDMS, plastics remain more suitable for industrial mass production of microfluidic devices rather than the rapid prototyping seen in most academic laboratories.…”

Section: Fabrication and Operationmentioning

confidence: 99%

Micro Total Analysis Systems for Cell Biology and Biochemical Assays

et al. 2011

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“…This monolithic approach is of interest, as recently highlighted [4][5][6], especially for handling fluids, as leakage is prevented thanks to the promotion of device integration, to the reduction of components and to the consequent elimination of joints between parts. As perceived from the aforementioned references, there is a growing concern towards more integrated design and manufacturing procedures linked to these engineering systems.…”

Section: Introductionmentioning

confidence: 99%

Monolithic 3D labs- and organs-on-chips obtained by lithography-based ceramic manufacture

Lantada

Romero

Schwentenwein³

et al. 2017

Int J Adv Manuf Technol

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In this study, we present a novel approach for the design and development of three-dimensional monolithic ceramic microsystems with complex geometries and with potential applications in the biomedical field, mainly linked to labson-chips and organs-on-chips. The microsystem object of study stands out for its having a complex three-dimensional geometry, for being obtained as a single integrated element, hence reducing components, preventing leakage and avoiding post-processes, and for having a cantilever porous ceramic membrane aimed at separating cell culture chambers at different levels, which imitates the typical configuration of transwell assays. The design has been performed taking account of the special features of the manufacturing technology and includes ad hoc incorporated supporting elements, which do not affect overall performance, for avoiding collapse of the cantilever ceramic membrane during debinding and sintering. The manufacture of the complex three-dimensional microsystem has been accomplished by means of lithography-based ceramic manufacture, the additive manufacturing technology which currently provides the most appealing compromises between overall part size and precision when working with ceramic materials. The microsystem obtained provides one of the most remarkable examples of monolithic bio-microsystems and, to our knowledge, a step forward in the field of ceramic microsystems with complex geometries for lab-on-chip and organ-on-chip applications. Cell culture results help to highlight the potential of the proposed approach and the adequacy of using ceramic materials for biological applications and for interacting at a cellular level.

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Fabrication of monolithic 3D micro-systems

Cited by 19 publications

References 28 publications

Embedded Adaptive Optics for Ubiquitous Lab-on-a-Chip Readout on Intact Cell Phones

Embedded Adaptive Optics for Ubiquitous Lab-on-a-Chip Readout on Intact Cell Phones

Micro Total Analysis Systems for Cell Biology and Biochemical Assays

Monolithic 3D labs- and organs-on-chips obtained by lithography-based ceramic manufacture

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