Fabrication of Multicore Milli- and Microcapsules for Controlling Hydrophobic Drugs Release Using a Facile Approach

Abstract

Herein, we designed two simple devices by exploiting the advantages of coaxial shear microfluidic and coextrusion minifluidic devices to generate multicore milliand microcapsules for encapsulating hydrophobic drugs. The number of cores could be precisely controlled by tailoring the flow rate or number of inner tubes. Similarly, the shell thickness and core size could be controlled accurately. In this study, the UV stability of α-tocopherol (model drug) capsules was investigated. The result shows that the oxidation rate of αtocopherol in millimeter capsules was much slower than that in free or micrometer capsules, which was related to the shell thickness of the capsules. Moreover, size-and core-numberdependent release was observed in vitro, where the millimeter capsules exhibited dramatic discrepancies of release rate compared with micrometer capsules. The release mechanism of capsules was primarily illustrated to include burst release, swelling and erosion release, and diffusion release, which was consistent with the phenomenon observed online using a highspeed camera.

Quasi‐continuous synthesis of iron single atom catalysts via a microcapsule pyrolysis strategy

“…All these advantages inspire us to use microcapsule as a novel template for the synthesis of SACs. More importantly, the pendant drop method, 36,37 as one of the well-established techniques of microcapsule preparation, possess a great potential to continuously produce high-quality microcapsule on account of the highly uniform droplets and high productivity. With abovementioned benefits, the inherent features of microcapsules provide the possibility to synthesize SACs through a continuous process.…”

“…Herein, inspired by our previous works on the controllable preparation of microcapsules [37][38][39] and on SACs, 20,40,41 we proposed a facile and efficient synthesis method by utilizing bulk emulsification and pendant drop technologies, to quasi-continuously synthesize S, N codoped carbon supported SACs (M/SNC, M=Fe, Ni, Co). This strategy includes three steps, (a) the continuous synthesis of metal precursor microcapsules encapsulated by chitosan (CS)/sodium dodecyl sulfate (SDS) hydrogel, and then followed by (b) pyrolysis and (c) acid washing.…”

Rapid Coating of Aqueous Pearls with Carbon Nanotubes via In Situ Polymerization of Dopamine

“…Millimeter-scale calcium alginate aqueous core capsules (mm-CaSA-Caps) which have excellent biocompatibility and biodegradability are suitable for embedding of temperature and chemical sensitive substances [10]. e mm-CaSA-Caps can be prepared with the orifice-bath coagulation method under mild reaction conditions [6,11,12] that the droplets containing calcium ion are dripped vertically to coagulating bath of alginate solution at room temperature. Size and sphericity of mm-CaSA-Caps can be controlled by regulating parameters of solution (concentration, surface tension, viscosity, and density) and parameter of equipment (extrusion velocity, diameter of dripper, and drop height).…”

Efficient Fabrication of Polymer Shell Colloidosomes by a Spray Drying Process

“…In the last few decades, hollow structure materials have attracted considerable attention due to their wide range of potential applications for pharmaceuticals, , agriculture, , fabrics, food, energy, and many other research areas. , One of the most common approaches for constructing hollow structures involves the formation of shells using preformed colloidal particles or polymers to synthesize polymer shell microcapsules. These microcapsules are normally micrometer-sized containers with polymer shells, which can protect the core materials (i.e., solid, liquid, or gas products) from the harsh denaturing environment, also known asmicroencapsulation .…”