Fabrication of multipotent poly-para-xylylene particles in controlled nanoscopic dimensions

Yuan, Ruei-Hung; Li, Yi-Jye; Sun, Ho-Yi; Wu, Chih‐Yu; Guan, Zhen‐Yu; Ho, Hsin-Ying; Fang, Cheng-Yuan; Chen, Hsien‐Yeh

doi:10.1016/j.colsurfb.2015.12.022

Cited by 8 publications

(5 citation statements)

References 39 publications

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“…Furthermore, the critical requirement of defined biointerface properties with nanoscale dimensions was demonstrated using PPX‐d‐NB. The two substitutions of benzoyl and NHS ester groups on PPX‐d‐NB resulted in an overall structure that was asymmetric and with high polarity, and these characteristics made PPX‐d‐NB soluble in polar solvents, similar to poly‐ para ‐xylylenes . In the experiment, we dissolved PPX‐d‐NB in DMF.…”

Section: Resultsmentioning

confidence: 99%

“…The average particle size was ≈245 nm as confirmed by dynamic light scattering (DLS) and also showed a PDI of 0.15. Theoretically, the particle size can be adjusted with respect to the compositions of the ternary components, including the polymer, solvent, and nonsolvent . In addition, IRRAS and XPS analyses were performed to characterize the resulting nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

“…PPX‐d‐NB nanocolloids were prepared by a nanoprecipitation method according to reported procedures . Briefly, PPX‐d‐NB was dissolved in DMF at a concentration of 500 μg mL −1 .…”

Section: Methodsmentioning

confidence: 99%

“…The multifunctional coating synthesized herein possesses coating fidelity due to its poly‐ p ‐xylylene predecessors and provides the flexibility of precise multitasking for the surface modification of prospective materials. Furthermore, by taking the solvent displacement approach for such a coating material, the phase change with respect to the solubility within a water/N,N‐Dimethylmethanamide (DMF) system can result in a material with nanoscopic dimensions, i.e., controlled nanocolloids that contain defined and coaxial conjugation sites of NHS ester and benzoyl functional conduits. As a proof‐of‐concept, the nanoscale material also provided a facile and precise approach to the concurrent immobilization of paclitaxel and folic acid molecules, demonstrating potential applications for targeted drug delivery against HeLa cancer cells.…”

Section: Introductionmentioning

confidence: 99%

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Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface

Yuan

Tung

et al. 2016

Macromolecular Bioscience

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A multicomponent functional polymer is synthesized to support specific reactivity for successful conjugation with the vast array of functionality present in biological systems and the flexibility to conjugate biomolecules without requiring additional modification to install a terminal functional group. The multifunctional surface is realized using a novel coating composed of distinct N-hydroxysuccinimide (NHS) ester and benzoyl functionalities, which can provide accessibility to both the NHS ester-amine coupling reaction and the photochemically induced benzophenone crosslinking reaction, respectively. In addition, the multifunctional polymer is fabricated and transformed to form nanoscale colloids through the solvent displacement of a water/DMF system due to solubility characteristics of the resulting polymer with high polarity. A facile and efficient fabrication approach using the multifunctional nanocolloid is thus demonstrated to create a drug carrier by installing paclitaxel and folic acid for targeted cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…PPX‐d‐NB nanocolloids were prepared by a nanoprecipitation method according to reported procedures . Briefly, PPX‐d‐NB was dissolved in DMF at a concentration of 500 μg mL −1 .…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface

Yuan

Tung

et al. 2016

Macromolecular Bioscience

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“…Recently, some anisotropic Janus NPs, which have two faces with differing physical or chemical characteristics, have been prepared by solution-based methods, including layer-by-layer assembly, Pickering emulsions, self-assembling, phase separation techniques, controlled nucleation and growth processes, microfluidic devices, and electro-hydrodynamic jetting . These anisotropic Janus NPs have achieved controlled assembly .…”

Section: Introductionmentioning

confidence: 99%

Semishell Janus Nanoparticle-Enabled pH-Responsive Rod-Shaped Assembly for Photothermal Therapy

García

et al. 2021

ACS Appl. Nano Mater.

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The controllable aggregation of nanoparticles in solution is an important but unsolved problem in nanotechnology, which is mainly hindered by the symmetrical structure of the nanoparticles. Here, we propose an anisotropic semishell nanostructure to achieve the rod-shaped assembly of nanoparticles in solution. The isotropic Au@silica core–shell nanoparticles are self-assembled on the silicon wafer by the drop-casting technique to form a monolayer film. Au@silica semishell nanoparticles are obtained after selectively removing part of the silica shell by reactive ion etching. After functionalization with pH-sensitive 4-mercaptobenzoic acid molecules, the semishell nanoparticles display pH-responsive localized surface plasmon resonance coupling and near-infrared light absorption, thereby holding great potential for noninvasive photothermal therapy.

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Vapor‐Phase Synthesis of Poly(para‐xylylene): From Coatings to Porous and Hierarchical Materials

Hu,

Lee,

Ramli

et al. 2024

Adv Funct Materials

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Poly(para‐xylylene) (PPX) is a robust and biocompatible coating material that is widely used in various applications, including electronics, aerospace and defense materials, automotive materials, and biomaterials. In this progress report, recent developments in PPX technology ranging from the advancement of physical chemistry properties and structural properties for device integration to the transformation of 3D monolith materials of PPX with controls in outer and inner structures at the micro‐ and nanometer scales are highlighted. Based on emerging chemistry studies on [2.2]paracyclophanes, which are primarily used precursors to synthesize PPX via vapor deposition polymerization, functionalization, and the creation of a wide variety of functional PPX derivatives are demonstrated without resistance. Widely used as an interface coating material, PPX is processed to form integrated structural materials and has already been found to be useful in the market as part of electronic and medical implant products. Using a newly innovated transformation to fabricate PPX through templates (metal‐organic frameworks, liquid crystal, ice crystal), 3D monoliths, nanoscale particles, hierarchical and gradient interior structures, and dynamically transformable shapes at the nanoscale are demonstrated. A vast landscape of novel applications and device products is expected based on the already established R&D and market maturity of PPX.

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Fabrication of multipotent poly-para-xylylene particles in controlled nanoscopic dimensions

Cited by 8 publications

References 39 publications

Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface

Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface

Semishell Janus Nanoparticle-Enabled pH-Responsive Rod-Shaped Assembly for Photothermal Therapy

Vapor‐Phase Synthesis of Poly(para‐xylylene): From Coatings to Porous and Hierarchical Materials

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