Fabrication of nanofibrous microcarriers mimicking extracellular matrix for functional microtissue formation and cartilage regeneration

Wang, Yansen; Yuan, Xueling; Yu, Kun; Meng, Hui; Zheng, Yudong; Peng, Jiang; Lu, Shibi; Liu, Xiaotong; Xie, Yu; Qiao, Ke

doi:10.1016/j.biomaterials.2018.04.033

Cited by 86 publications

(81 citation statements)

References 52 publications

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“…Taking advantage of the mechanical properties and structural similarity between BC and ECM, Wang et al . designed ECM‐mimicking microcarriers ( Figure ).…”

Section: Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

127

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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“…Taking advantage of the mechanical properties and structural similarity between BC and ECM, Wang et al . designed ECM‐mimicking microcarriers ( Figure ).…”

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

127

View full text Add to dashboard Cite

show abstract

“…The pore size of scaffold should be within critical range of lower bound determined by cell size and upper bound determined by binding sites or specific surface area. For bone tissues, the pore size of scaffolds is expected to fall between 100–500 µm [ 78 , 79 ]. Also, the pore geometry should be conducive to cell morphology.…”

Section: Native Bone Structure and Compositionmentioning

confidence: 99%

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

2018

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Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.

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“…In recent years, the microcarrier-based approach of 3D cell culture has also opened a door for fabrication of engineered tissues, which is one of the cutting-edge topics in tissue engineering and regeneration medicine. Different engineered/artificial tissues have been developed from cell-laden microcarriers either as model tissues for pharmacological and pathological studies or for tissue regeneration [44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation

Huang

Abdalla

Xiao

et al. 2020

IJMS

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The concept of three-dimensional (3D) cell culture has been proposed to maintain cellular morphology and function as in vivo. Among different approaches for 3D cell culture, microcarrier technology provides a promising tool for cell adhesion, proliferation, and cellular interactions in 3D space mimicking the in vivo microenvironment. In particular, microcarriers based on biopolymers have been widely investigated because of their superior biocompatibility and biodegradability. Moreover, through bottom-up assembly, microcarriers have opened a bright door for fabricating engineered tissues, which is one of the cutting-edge topics in tissue engineering and regeneration medicine. This review takes an in-depth look into the recent advancements of microcarriers based on biopolymers—especially polysaccharides such as chitosan, chitin, cellulose, hyaluronic acid, alginate, and laminarin—for 3D cell culture and the fabrication of engineered tissues based on them. The current limitations and potential strategies were also discussed to shed some light on future directions.

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Fabrication of nanofibrous microcarriers mimicking extracellular matrix for functional microtissue formation and cartilage regeneration

Cited by 86 publications

References 52 publications

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation

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