2023
DOI: 10.3390/ph16040561
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Fabrication of Nanoformulation Containing Carvedilol and Silk Protein Sericin against Doxorubicin Induced Cardiac Damage in Rats

Abstract: Nanotechnology has emerged as an inspiring tool for the effective delivery of drugs to help treat Coronary heart disease (CHD) which represents the most prevalent reason for mortality and morbidity globally. The current study focuses on the assessment of the cardioprotective prospective ofanovel combination nanoformulation of sericin and carvedilol. Sericin is a silk protein obtained from Bombyx mori cocoon and carvedilol is a synthetic nonselective β-blocker. In this present study, preparation of chitosan nan… Show more

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Cited by 4 publications
(1 citation statement)
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“…These components endow SC with significant biological activities, not only enhancing the traditional health benefits, but also providing foundational properties for innovative therapeutic techniques. The therapeutic actions of SS and SF are extensive, including antidiabetic effects [6,7], cardioprotective properties [8][9][10], and lipid-lowering capabilities [11]. Concurrently, the ability to modulate inflammatory responses [12][13][14] and resist oxidative stress [15][16][17][18] broadens their application in disease prevention and treatment.…”
Section: Introductionmentioning
confidence: 99%
“…These components endow SC with significant biological activities, not only enhancing the traditional health benefits, but also providing foundational properties for innovative therapeutic techniques. The therapeutic actions of SS and SF are extensive, including antidiabetic effects [6,7], cardioprotective properties [8][9][10], and lipid-lowering capabilities [11]. Concurrently, the ability to modulate inflammatory responses [12][13][14] and resist oxidative stress [15][16][17][18] broadens their application in disease prevention and treatment.…”
Section: Introductionmentioning
confidence: 99%