Systematic research on a new type of gas sensor devices based on the thermovoltaic effect in zinc oxide, inhomogeneously doped with impurities of variable valence, is presented in the article. The ZnO-ZnO-Me two-layer sandwich structure, in which the thermovoltaic effect is observed, is synthesized using sol-gel technology from sols by dissolving the inorganic zinc salt in alcohol and adding a surfactant, followed by the mixing and maturation of the sol. The lower layer of the nanostructure is formed from pure zinc oxide by immersing the substrate at 2 /3 length in sol and drying. The upper layer of zinc oxide doped with copper or iron is formed by two or three immersions of the other end of the substrate by 2 /3 length, followed by drying and annealing. It has been established that, based on the developed sensor device, it is possible to obtain an increased response to gas-analyzers (ethanol being an example). Author Contributions: Conceptualization, I.P. and V.M.; formal analysis, I.A. and V.M.; investigation, I.P. and N.Y.; methodology, D.D.; software, A.K.; visualization, A.K.