Fabrication of Novel Electroconductive PAN/PEDOT:PSS Nanofibers for Osteochondral Tissue Regeneration

Abstract

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Synergy between 3D-extruded electroconductive scaffolds and electrical stimulation to improve bone tissue engineering strategies

“…[31][32][33] Poly (3,4ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) is an ECP, suitable for the design of TE scaffolds due to its high stability and biocompatibility. [34][35][36] For example, Guex and colleagues 37 reported the development of an electroconductive (6.1 Â 10 À6 S cm À1 ) ice-templated PEDOT:PSS scaffold capable of supporting MC3T3-E1 cells' osteogenic differentiation and the deposition of the mineralized extracellular matrix (ECM). PEDOT:PSS can also be processed into versatile electroconductive composites with collagen 38 and nanohydroxyapatite/chitosan 39 for bone TE applications.…”