Fabrication of Ordered Arrays of Biodegradable Polymer Pincushions Using Self‐Organized Honeycomb‐Patterned Films

Tanaka, Masaru; Takebayashi, Masafumi; Shimomura, Masatsugu

doi:10.1002/masy.200950527

Cited by 19 publications

(13 citation statements)

References 39 publications

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“…A few papers were focused on the preparation and application of honeycomb microporous films from PLA [41]. However, few attempts have been put to some commercial polymer materials, such as PMMA and PC [42,43]. So our aim is to fabricate honeycomb microporous films from diverse polymer materials by a general BF strategy.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of polymeric honeycomb microporous films: breath figures strategy and stabilization of water droplets by fluorinated diblock copolymer micelles

Qin

Yuan

et al. 2012

J Mater Sci

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Polymeric honeycomb microporous films were prepared from fluorinated diblock copolymers, poly(tert-butyl acrylate)-b-poly(2-[(perfluorononenyl)oxy]ethyl methacrylate) (PtBA-b-PFNEMAs), and four other commercial polymers, including polystyrene (PS), polycarbonate (PC), polylactic acid (PLA), and polymethylmethacrylate (PMMA) via breath figures method. The as-formed fluorinated diblock copolymer micelles in chloroform were not only utilized to stabilize the templated water droplets in bulk, but also introduced as the water droplets stabilizer in other polymeric materials. Our strategy was successfully achieved, as the micropores were decorated with the fluorinated diblock copolymer as directly shown in the SEM images and FT-IR/ ATR-FTIR. Polymer concentration and the solution casting volume effects were checked to tune the sizes of the micropores in diblock copolymer films. The ratio of the added fluorinated diblock copolymer as a novel factor to tune the sizes of the micropores was also investigated.

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Section: Resultsmentioning

confidence: 99%

Fabrication of polymeric honeycomb microporous films: breath figures strategy and stabilization of water droplets by fluorinated diblock copolymer micelles

Qin

Yuan

et al. 2012

J Mater Sci

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“…The size of each droplet might be suitable as omnidirectional anchors for the attachment of cells. The shape of each pore elements of the honeycomb film could be precisely uniformed, so that the diameter of apertures to the hollow inside of the honeycomb structure would be actually constant (21) . A minimum gauge of the aperture that cells of a human biotissue could pass through to migrate, was defined to 6-µm (22) .…”

Section: Discussionmentioning

confidence: 99%

Proliferation of Periodontal Ligament Cells on Biodegradable Honeycomb Film Scaffold with Unified Micropore Organization

Ishihata

Tanaka

Iwama

et al. 2010

JBSE

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Tissue-engineered grafts using a scaffold can be used in treating periodontal disease; however, previous scaffolds for the cultivations of the periodontal ligament cells have been structurally incompatible with the morphological requirements of human periodontal tissue. Here, we describe a self-organized honeycomb-patterned film (honeycomb film) that acted as an appropriate scaffold for periodontal tissue regeneration. The honeycomb films were prepared from biodegradable poly(ε-caprolactone) with highly regular three-dimensional micropatterned surface topography by casting a polymer solution of water-immiscible solvent under humid conditions. To evaluate its performance in activating the proliferation and organizing of cells, we have demonstrated specific behaviors of the cultured periodontal ligament cells on the self-organized honeycomb structures in vitro. Fibroblast-like cells derived from the periodontal ligament of extracted human molar teeth were cultivated on three types of honeycomb films with 5-, 10-, and 15-µm pore sizes for 4 h to 42 d. Morphological observation of the cultured tissues at 4-72 h revealed that the pseudopodiums of cell bodies were attached to the pillars in the honeycomb structure. A certain number of cells shifted their cell bodies into the honeycomb structural lumen through the oscula of 10-and 15-µm pores. After 28 and 42 d, the cells were observed to have formed multiple layers; further, each cell had penetrated through the 10-and 15-µm pores in the honeycomb film. The morphological examination of the honeycomb film along with the pillar structures revealed that the scaffold was clusteringly arrayed with interconnected structures, remarkably enhanced proliferation, and extension of the cultured cells. We consider that the film can be applied in periodontal therapy for use as a scaffold for periodontal tissue regeneration.

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“…Typically, a hexagonal array of spherical pores with an average diameter (D ) of 0.60 mm was observed by SEM and AFM (Figure 1). A pincushion-like structure was obtained after peeling off the top surface of the film with adhesive tape (Figure 1b), [37] which also indicates that the pores are interconnected throughout the thin film. From the AFM section analysis (Figure 1d), the pores are monolayered and the average hole depth is about 170 nm.…”

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confidence: 99%

Tunable Morphology of 2D Honeycomb‐Patterned Films and the Hydrophobicity of a Ferrocenyl‐Based Oligomer

Dong

Yan

et al. 2011

Chemistry A European J

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Honeycomb-patterned polymer films with tunable pore size and regularity of ordered two- or three-dimensional hexagonal arrays have met with widespread interest in recent years in different areas, for instance as separation and superhydrophobic materials. Herein, 2D honeycomb-patterned films of amphiphilic ferrocenyl-based oligomer with cholesterol as side chains were prepared by the breath-figure method on solid surfaces and their surface-wetting behavior were tested. These films can be simply prepared by spreading a mixture of polymer and organic solvents on a solid surface under moist airflow and at an air/water interface without any extra moist airflow. An ordered 2D hexagonal array of pores with monodisperse size distribution can be obtained over a large area by changing various influencing factors, including humidity, wet volume, concentration, selective solvent, and spreading method, which provides a facile route to regulate the morphology of patterned porous films. The surface-wetting behavior indicates that a higher hydrophobicity of the ferrocenyl-based oligomer honeycomb films can be obtained by modulating the pore size and regularity. It is expected that this could promote the potential application of ordered porous polymer films in hydrophobic materials and biochemistry.

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Fabrication of Ordered Arrays of Biodegradable Polymer Pincushions Using Self‐Organized Honeycomb‐Patterned Films

Cited by 19 publications

References 39 publications

Fabrication of polymeric honeycomb microporous films: breath figures strategy and stabilization of water droplets by fluorinated diblock copolymer micelles

Fabrication of polymeric honeycomb microporous films: breath figures strategy and stabilization of water droplets by fluorinated diblock copolymer micelles

Proliferation of Periodontal Ligament Cells on Biodegradable Honeycomb Film Scaffold with Unified Micropore Organization

Tunable Morphology of 2D Honeycomb‐Patterned Films and the Hydrophobicity of a Ferrocenyl‐Based Oligomer

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