Fabrication of Oregano-Olive Oil Loaded PVA/Chitosan Nanoparticles via Electrospraying Method

Vehapi, Meyrem; Yïlmaz, Aydan; Özçimen, Didem

doi:10.1080/15440478.2020.1774463

Cited by 20 publications

(6 citation statements)

References 30 publications

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“…Along the same lines, the positive values of ZP for VOO-loaded PBA-CSNPs (NF-2) (+16.21 mV) and HT-loaded PBA-CSNPs (NF-3) (+19.76 mV) were turned into negatives of −21.39 mV and −15.13 mV, respectively, by increasing the pH from 4.5 to 8.5. The nanocapsules (NF-2 and NF-3) formed exhibit high zeta potential values, indicating that they are more resistant to agglomerating into bulky particles owing to repulsive interactions [ 23 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…As a result of the high degree of swelling, as well as the solubilization and washing of the nanocapsules, a rapid burst release occurred. Over time, the release medium eventually had enough time to enter the internal layers of the nanocapsules and establish equilibrium [ 44 ]. A reduced oil hydrophilia is likely to be the cause of the insignificant release of NF-2 after 24 h of dialysis against PBS.…”

Section: Resultsmentioning

confidence: 99%

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Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol

et al. 2022

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Olives and virgin olive oil (VOO) are a staple of Mediterranean diets and are rich in several beneficial phenolic compounds, including hydroxytyrosol (HT). Therefore, VOO was extracted from Koroneiki olive fruits, and its volatile as well as phenolic components were identified. Meanwhile, in order to upgrade the pharmaceutical capabilities of VOO and HT, a new conjugate phenylboronic acid-chitosan nanoparticles (PBA-CSNPs, NF-1) was fabricated and applied as nanocapsules for implanting high loading and efficient delivery of VOO and HT nanoformulations (NF-2 and NF-3). Due to the H-bonding interactions and boronate ester formation between the hydroxyl groups of the phenolic content of VOO or HT and the PBA groups in the nanocapsules (NF-1), VOO and HT were successfully loaded into the PBA-CSNPs nanocapsules with high loading contents and encapsulation efficacies. The NF-2 and NF-3 nanoformulations demonstrated physicochemical stability, as revealed by their respective zeta potential values, and pH-triggered drug release characteristics. The in vitro studies demonstrated that the nascent nanocapsules were almost completely nontoxic to both healthy and cancer cells, whereas VOO-loaded (NF-2) and HT-loaded nanocapsules (NF-3) showed efficient anti-breast cancer efficiencies. In addition, the antimicrobial and antioxidant potentials of VOO and HT were significantly improved after nanoencapsulation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol

et al. 2022

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“…Dentre os diversos processos tecnológicos pode-se citar: uso de microondas (Cherif, Rodrigues, et al, 2021), gel de emulsão (Alongi, et al, 2022;Muñoz-González, et al, 2021), armazenamento em shotgun lipidomics (Capriotti et al, 2021), armazenamento reduzido (BELTRAN et al, 2021, sensor analítico ecológico (Jebril et al, 2021), ultrassom (Del Coco et al, 2021, casca da cebola amarela como estabilizador (CRNIVEC et al, 2021), caracterização sensorial pelo método CATA (Melo et al, 2021), cromatografia (Marx et al, 2021), temperatura adequada de malaxação (Marx et al, 2021;Olmo-Cunillera et al, 2021), encapsulação (Tirado, et al, 2021;Vehapi, et al, 2020;Yao et al, 2021), acréscimo de especiaria , métodos de informática para prever alvos moleculares (Fatoki, et al, 2021), membranas de emulsão a base de líquido iônico (Khan et al, 2021).…”

Section: Biochemical Engineering Journalunclassified

Compostos bioativos presentes no azeite de oliva e seus subprodutos: revisão bibliográfica

Basso

Uliana

Richards

2022

RSD

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O objetivo do estudo foi investigar acerca do que está sendo questionado por renomados pesquisadores em todas as partes do mundo, ou seja, especular em relação aos países que mais publicam quando o assunto se refere a azeite e seus subprodutos, quais são os maiores produtores, qual a qualidade desses produtos oferecidos ao mercado, quais as melhores técnicas para preservar os compostos benéficos à saúde, além de lacunas que possam instigar a mais pesquisas elucidativas. Ocorreu através de revisão da literatura, utilizando os descritores ¨Azeite de Oliva¨ e ¨Bioativos¨. A pesquisa foi refinada almejando como forma de documento somente artigos, estes com publicação nos anos de 2021 e 2022. Posteriormente os artigos selecionados foram direcionados para análise bibliométrica. Em posse dos 109 artigos pré-selecionados, fez-se um novo refinamento, analisando-se então 78 artigos, os quais foram categorizados em cinco tópicos de maior importância: Resíduos da produção do azeite de oliva, processo tecnológico para análise do azeite, parâmetros químicos de diferentes cultivares, compostos bioativos, processo para determinação dos compostos bioativos. Após análise minuciosa de todos os artigos selecionados, referente inicialmente a compostos bioativos e azeite de oliva, e no decorrer adicionado subprodutos da produção do azeite, pode-se comprovar acerca dos benefícios dos compostos bioativos, formas de melhor preservá-los, além de algumas tendências em relação a sustentabilidade e preservação do meio ambiente, e por fim, identificação de métodos que podem se tornar promissores: bioinformática a fim de predizer propriedades medicinais e análise sensorial corroborando com técnicas analíticas e químicas.

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“…Interestingly, using an in vitro gastric condition simulating test, the authors showed that each polymeric layer influenced OEO bioaccessibility, obtaining the highest value for the three-layer system. Spherical polymeric NPs based on polyvinyl alcohol (PVA) and chitosan loaded with OEO have also been prepared by electrospraying (Vehapi et al, 2020 ). Results demonstrated that the encapsulation of OEO and the presence of chitosan led to a superior antifungal effect of the nanoencapsulated system compared to free OEO.…”

Section: Oeo Nanoencapsulationmentioning

confidence: 99%

Oregano Essential Oil Micro- and Nanoencapsulation With Bioactive Properties for Biotechnological and Biomedical Applications

Pontes-Quero

Esteban-Rubio²,

Cano³

et al. 2021

Front. Bioeng. Biotechnol.

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Due to the preservative, antioxidant, antimicrobial, and therapeutic properties of oregano essential oil (OEO), it has received an emerging interest for biotechnological and biomedical applications. However, stability and bioactivity can be compromised by its natural volatile and hydrophobic nature, and by external factors including light, heat, or oxygen. Therefore, micro- and nanoencapsulation are being employed to guarantee oregano oil protection from outside aggressions and to maximize its potential. Oregano oil encapsulation is an interesting strategy used to increase its stability, enhance its bioactivity, and decrease its volatility. At the same time, the versatility that micro- and nanocarriers offer, allows to prepare tailored systems that can provide a controlled and targeted release of the encapsulated principle, influence its bioactive activities, or even provide additional properties. Most common materials used to prepare these carriers are based on lipids and cyclodextrins, due to their hydrophobic nature, polymers due to their versatility in composition, and hybrid lipid-polymer systems. In this context, recently developed micro- and nanocarriers encapsulating oregano oil with applications in the biotechnological and biomedical fields will be discussed.

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Fabrication of Oregano-Olive Oil Loaded PVA/Chitosan Nanoparticles via Electrospraying Method

Cited by 20 publications

References 30 publications

Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol

Phenylboronic Acid-Grafted Chitosan Nanocapsules for Effective Delivery and Controllable Release of Natural Antioxidants: Olive Oil and Hydroxytyrosol

Compostos bioativos presentes no azeite de oliva e seus subprodutos: revisão bibliográfica

Oregano Essential Oil Micro- and Nanoencapsulation With Bioactive Properties for Biotechnological and Biomedical Applications

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