Fabrication of PDMS microfluidic devices with 3D wax jetting

Li, Zongan; Yang, Jiquan; Li, Kelou; Zhu, Li; Tang, Wencheng

doi:10.1039/c6ra24884e

Cited by 47 publications

(37 citation statements)

References 41 publications

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“…The examine the applicability of such braid mixers produced by subtractive manufacturing in real‐world applications, their capability to assemble polymeric nanomaterials for biomedical use was investigated, extending prior work in simpler geometries . A complete optimization to the generation of nanoparticles was not within the scope of this manuscript.…”

Section: Resultsmentioning

confidence: 99%

“…Others presented the use of an open‐source 3D wax printer for the fabrication of PDMS devices such as a micro‐droplet generator and 3D chaotic passive mixer. Printed wax structures were placed on glass slides, PDMS was added, cured, and removed with a solvent and finally the chip plasma treated and bonded to a glass chip . Likewise, femtosecond lasers allow direct writing in transparent materials, for example performing ablation of 3D polymer structures based on multiphoton absorption as reported by Jiang et al…”

Section: Introductionmentioning

confidence: 99%

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Subtractive Manufacturing of Microfluidic 3D Braid Mixers

2018

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Subtractive manufacturing using the thread template approach is an emerging technique for rapid prototyping of complex, true 3D microfluidic systems, offering advantages to photolithography in terms of process complexity, and achieving excellent structure fidelity compared to 3D printing and micro-milling. This paper explores subtractive manufacturing for novel high-performance microfluidic 3D braid mixers. The broad freedom of design with subtractive manufacturing, that is achievable with minimal process complexity is exploited to study the impact of design parameters of such braid mixers on mixing performance. The braid mixer is compared by computational fluid dynamics and experimentally with a number of existing mixer designs using colorimetric chemical reactions. The use of a braid mixer in a streamlined production of nanomaterials in a multistep procedure, shows highly competitive performance compared to other microfluidic designs and nanoparticle assembly methods.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subtractive Manufacturing of Microfluidic 3D Braid Mixers

2018

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“…Adapted with permission from Ref. [135]. prepolymer can be cast against the caramel master and covered with a second glass slide.…”

Section: Sacrificial Mastersmentioning

confidence: 99%

“…For example, wax has been used in microfluidic applications to make overlapping junctions and high aspect ratio channels -structures that would be difficult to make using traditional replica molding ( Figure 5F, G). [135,136] It has also been used to define patterns in conjunction with photocurable polymers to make masters for thermoplastic domed or concave structures for cellular assays. In this process, wax masks define the area for the photocurable polymer droplets and the entire structure is subsequently covered in thermoset polymer and cured.…”

Section: Sacrificial Mastersmentioning

confidence: 99%

Emergent Soft Lithographic Tools for the Fabrication of Functional Polymeric Microstructures

2019

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Polymeric microstructures (PMs) are useful to a broad range of technologies applicable to, for example, sensing, energy storage, and soft robotics. Due to the diverse application space of PMs, many techniques (e. g., photolithography, 3D printing, micromilling, etc.) have been developed to fabricate these structures. Stemming from their generality and unique capabilities, the tools encompassed by soft lithography (e. g., replica molding, microcontact printing, etc.), which use soft elastomeric materials as masters in the fabrication of PMs, are particularly relevant. By taking advantage of the characteristics of elastomeric masters, particularly their mechanical and chemical properties, soft lithography has enabled the use of non‐planar substrates and relatively inexpensive equipment in the generation of many types of PMs, redefining existing communities and creating new ones. Traditionally, these elastomeric masters have been produced from relief patterns fabricated using photolithography; however, recent efforts have led to the emergence of new methods that make use of masters that are self‐forming, dynamic in their geometric and chemical properties, 3D in architecture, and/or sacrificial (i. e., easily removed/released using phase changes). These “next generation” soft lithographic masters include self‐assembled liquid droplets, microscale balloons, templates derived from natural materials, and hierarchically microstructured surfaces. The new methods of fabrication supported by these unique masters enable access to numerous varieties of PMs (e. g., those with hierarchical microstructures, overhanging features, and 3D architectures) that would not be possible following established methods of soft lithography. This review explores these emergent soft lithographic methods, addressing their operational principles and the application space they can impact.

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“…This causes swelling and damage of the microchannels. For 3D printing of soft wax based on an FDM method, the surface of the 3D‐printed mold becomes bumpy . On the other hand, inkjet‐type 3D printing of hard wax can realize smooth and fine structures (Figure S6, Supporting Information), so that our fabrication method can form grooves inside microchannels and avoid rough structure surfaces.…”

mentioning

confidence: 99%

3D Helical Micromixer Fabricated by Micro Lost‐Wax Casting

Tachibana

Matsubara

Matsuda

et al. 2019

Adv Materials Technologies

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/admt.201900794.Many micro total analysis systems (microTAS) and lab-on-achip applications have been developed that provide various functions such as mixing, [1,2] heating, [3,4] separation, [5][6][7] and extraction. [8,9] These applications are crucial to point-of-care testing (POCT), especially in developing countries. [10] These

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Fabrication of PDMS microfluidic devices with 3D wax jetting

Abstract: Network flowing on the 3D PDMS microfluidic chips fabricated with replication of a 3D printed wax mold.

Cited by 47 publications

References 41 publications

Subtractive Manufacturing of Microfluidic 3D Braid Mixers

Subtractive Manufacturing of Microfluidic 3D Braid Mixers

Emergent Soft Lithographic Tools for the Fabrication of Functional Polymeric Microstructures

3D Helical Micromixer Fabricated by Micro Lost‐Wax Casting

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