Fabrication of pH-responsive monodisperse microcapsules using interfacial tension of immiscible phases

Thakare, Dhawal R.; Schaer, Grayson; Yourdkhani, Mostafa; Sottos, Nancy R.

doi:10.1039/d0sm00301h

Cited by 11 publications

(6 citation statements)

References 50 publications

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“…It is possible to produce double-emulsion drops without a flow of continuous phase using a vibrating capillary nozzle. 39 With a nozzle of two coaxially-aligned capillaries, the innermost and middle phases are injected into a stationary continuous phase in a bath. As the nozzle vibrates immediately below the interface between the continuous phase and air, the core-sheath flow is emulsified at the moment when the dangling drops approach the interface.…”

Section: Microfluidic Productionmentioning

confidence: 99%

Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating

et al. 2022

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Section: Microfluidic Productionmentioning

confidence: 99%

Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating

et al. 2022

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“…Unfortunately, the passive reagent transport prohibits the close control over the timing and location of the reagent release that would be required to build nature-inspired materials. Temporal control over the reagent release can be achieved if capsule shells are made of materials that respond to certain stimuli such as temperature, [77,78] pH, [79,80] the presence of certain oils, [81] enzymes [82,83] or even mechanical crack propagation in the case of certain capsule-based self-healing composites [84]. However, these capsules offer a poor control over the type and amount of liberated reagents as the trigger usually causes a burst release.…”

Section: Bioinspired Materials Processingmentioning

confidence: 99%

From vesicles to materials: bioinspired strategies for fabricating hierarchically structured soft matter

Amstad

Harrington

2021

Phil. Trans. R. Soc. A.

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Certain organisms including species of mollusks, polychaetes, onychophorans and arthropods produce exceptional polymeric materials outside their bodies under ambient conditions using concentrated fluid protein precursors. While much is understood about the structure-function relationships that define the properties of such materials, comparatively less is understood about how such materials are fabricated and specifically, how their defining hierarchical structures are achieved via bottom-up assembly. Yet this information holds great potential for inspiring sustainable manufacture of advanced polymeric materials with controlled multi-scale structure. In the present perspective, we first examine recent work elucidating the formation of the tough adhesive fibres of the mussel byssus via secretion of vesicles filled with condensed liquid protein phases (coacervates and liquid crystals)—highlighting which design principles are relevant for bio-inspiration. In the second part of the perspective, we examine the potential of recent advances in drops and additive manufacturing as a bioinspired platform for mimicking such processes to produce hierarchically structured materials. This article is part of the theme issue ‘Bio-derived and bioinspired sustainable advanced materials for emerging technologies (part 1)’.

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“…Actives can be loaded into the microcapsules and then transferred to the target sites. External stimuli, such as pH values [10], temperatures [11], or stresses [12][13][14] are often considered as the effective strategies to release the contents through permeability changes or mechanical degradation of the shell. The design of functional microcapsules for specific purposes requires the well-controlled and known shell properties such as the structure and mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Mechanical characterization of core-shell microcapsules

Xie¹,

Léonetti²

2023

Comptes Rendus. Mécanique

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Core-shell configurations are ubiquitous in nature such as in the form of bacterial and cells. Inspired by this, microcapsules are designed with actives as the cores surrounded by thin shells. They not only play an increasing role as artificial models for understanding dynamic behaviors of biological cells in flows, but are also becoming a fundamental class of artificial vehicles at the heart of drug delivery and release in applications. The mechanical properties of the shells are of great importance in this context. Here, we review recent experimental and theoretical characterizations of microcapsules, focusing on the soft and deformable particles with liquid cores. We begin by exploring the concept and fabrication of artificial microcapsules, followed by a discussion of different methods on the mechanical characterization of the shell.

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Fabrication of pH-responsive monodisperse microcapsules using interfacial tension of immiscible phases

Abstract: Monodisperse stimuli-responsive microcapsules are difficult to fabricate with precise control over capsule properties. The paper reports a facile technique to produce highly tunable and monodisperse emulsion-templated acid-responsive microcapsules.

Cited by 11 publications

References 50 publications

Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating

Recent advances in the microfluidic production of functional microcapsules by multiple-emulsion templating

From vesicles to materials: bioinspired strategies for fabricating hierarchically structured soft matter

Mechanical characterization of core-shell microcapsules

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