Fabrication of pH-responsive nanoparticles for co-delivery of fungicide and salicylic acid with synergistic antifungal activity

Huang, Yuqi; Wang, Huachen; Tang, Gang; Zhou, Zhiyuan; Zhang, Xiaohong; Liu, Yulu; Yan, Guangyao; Wang, Jialu; Hu, Gaohua; Xiao, Jianhua; Yan, Weiyao; Cao, Yongsong

doi:10.1016/j.jclepro.2024.142093

Journal of Cleaner Production

2024

DOI: 10.1016/j.jclepro.2024.142093

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Fabrication of pH-responsive nanoparticles for co-delivery of fungicide and salicylic acid with synergistic antifungal activity

Yuqi Huang,

Huachen Wang,

Gang Tang

et al.

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Cited by 5 publications

References 61 publications

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Colloids and Surfaces B: Biointerfaces

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Fabrication of zein-coated brush-like silica nanocarriers for high foliage deposition and responsive release of pesticide

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Colloids and Surfaces B: Biointerfaces

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Cocrystal engineering for sustained release of dicamba: Mitigating secondary drift and reducing leaching

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Unraveling the Potential of Vitamin B₃-Derived Salts with a Salicylate Anion as Dermal Active Agents for Acne Treatment

Olejniczak,

Stachowiak,

Ziental

et al. 2024

Mol. Pharmaceutics

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This study is focused on the utilization of naturally occurring salicylic acid and nicotinamide (vitamin B3) in the development of novel sustainable Active Pharmaceutical Ingredients (APIs) with significant potential for treating acne vulgaris. The study highlights how the chemical structure of the cation significantly influences surface activity, lipophilicity, and solubility in aqueous media. Furthermore, the new ionic forms of APIs, the synthesis of which was assessed with Green Chemistry metrics, exhibited very good antibacterial properties against common pathogens that contribute to the development of acne, resulting in remarkable enhancement of biological activity ranging from 200 to as much as 2000 times when compared to salicylic acid alone. The molecular docking studies also revealed the excellent anti-inflammatory activity of N-alkylnicotinamide salicylates comparable to commonly used drugs (indomethacin, ibuprofen, and acetylsalicylic acid) and were even characterized by better IC50 values than common anti-inflammatory drugs in some cases. The derivative, featuring a decyl substituent in the pyridinium ring of nicotinamide, exhibited efficacy against Cutibacterium acnes while displaying favorable water solubility and improved wettability on hydrophobic surfaces, marking it as particularly promising. To investigate the impact of the APIs on the biosphere, the EC50 parameter was determined against a model representative of crustaceansArtemia franciscana. The majority of compounds (with the exception of the salt containing the dodecyl substituent) could be classified as “Relatively Harmless” or “Practically Nontoxic”, indicating their potential low environmental impact, which is essential in the context of modern drug development.

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Fabrication of pH-responsive nanoparticles for co-delivery of fungicide and salicylic acid with synergistic antifungal activity

Cited by 5 publications

References 61 publications

Fabrication of zein-coated brush-like silica nanocarriers for high foliage deposition and responsive release of pesticide

Fabrication of zein-coated brush-like silica nanocarriers for high foliage deposition and responsive release of pesticide

Cocrystal engineering for sustained release of dicamba: Mitigating secondary drift and reducing leaching

Unraveling the Potential of Vitamin B₃-Derived Salts with a Salicylate Anion as Dermal Active Agents for Acne Treatment

Contact Info

Product

Resources

About

Fabrication of pH-responsive nanoparticles for co-delivery of fungicide and salicylic acid with synergistic antifungal activity

Cited by 5 publications

References 61 publications

Fabrication of zein-coated brush-like silica nanocarriers for high foliage deposition and responsive release of pesticide

Fabrication of zein-coated brush-like silica nanocarriers for high foliage deposition and responsive release of pesticide

Cocrystal engineering for sustained release of dicamba: Mitigating secondary drift and reducing leaching

Unraveling the Potential of Vitamin B3-Derived Salts with a Salicylate Anion as Dermal Active Agents for Acne Treatment

Contact Info

Product

Resources

About

Unraveling the Potential of Vitamin B₃-Derived Salts with a Salicylate Anion as Dermal Active Agents for Acne Treatment