Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive

Lu, Min; Liu, Yi; Huang, Yung Chi; Huang, Chun Jen; Tsai, Wei‐Bor

doi:10.1016/j.carbpol.2017.11.097

Cited by 83 publications

(40 citation statements)

References 47 publications

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“…Usually, injectable hydrogels are formed by chemical cross-linkers [35], temperature-responsive phase transition [36], or enzymatic crosslinking reactions [30]. Most notably, injectable hydrogels formed by photo-crosslinking reactions have attracted more and more attention because the reactions can be easily controlled by UV exposure [37,38,39]. However, the too short UV exposure time go against to obtain hydrogels with strong mechanical properties and long exposure time is not conducive to the survival of the encapsulated cells.…”

Section: Introductionmentioning

confidence: 99%

A Hyaluronic Acid Based Injectable Hydrogel Formed via Photo-Crosslinking Reaction and Thermal-Induced Diels-Alder Reaction for Cartilage Tissue Engineering

et al. 2018

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A hyaluronic acid (HA) based injectable hydrogel with gradually increasing mechanical properties was synthesized via photo-crosslinking reaction and thermal-induced Diels-Alder (DA) reaction. The injectable hydrogel can quickly gelate within 30 s by photo-crosslinking of HA-furan under the catalysis of lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). This injectable property is beneficial to keep the encapsulated cell activity and convenient for clinical operation. And the mechanical properties can be control from 4.86 to 10.66 kPa by exposure time. Then, the thermal-induced DA click chemistry further occurs between furan groups and maleimide groups which gradually promoted the crosslinking density of the injectable hydrogel. The mechanical properties of the injectable hydrogel can be promoted to 21 kPa. ATDC-5 cells were successfully encapsulated in the injectable hydrogel and showed good activity. All the results suggested that the injectable hydrogel with gradually increasing mechanical properties formed by photo-crosslinking reaction and thermal-induced DA reaction has a good prospect of application in cartilage tissue engineering.

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Section: Introductionmentioning

confidence: 99%

A Hyaluronic Acid Based Injectable Hydrogel Formed via Photo-Crosslinking Reaction and Thermal-Induced Diels-Alder Reaction for Cartilage Tissue Engineering

et al. 2018

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“…Semipermanent junction points would be formed by the interanchored long chains with enough strength in the polymer network, and the formed networks give an enhancement of the contact and preservation of water molecules . The mount of hydrophilic groups of the polysaccharide varies from a fraction to several thousand times of their own weight when swelled with water . Some functional sections can stabilize the 3D frameworks that allow the interchains conglutinating to avoid dissolution of gels.…”

Section: Fabrication Of Polysaccharide‐based Hydrogelsmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

276

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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“…G-CH is a derivative of CH with the primary hydroxyl groups of each sugar unit modified to ethylene glycol units. Using an N-3-dimethylaminopropyl-N-ethylcarbodiimide hydrochloride (EDC)-based coupling reaction between the amine groups of G-CH and carboxylic acid groups of phloretic acid, Lu et al [75]. conjugated phenol pendant groups to glycol chitosan.…”

Section: Photoreactive Tissue Adhesives Derived From Chitosanmentioning

confidence: 99%

Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers

Narayanan

Dhinojwala

et al. 2020

ChemEngineering

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To stop blood loss and accelerate wound healing, conventional wound closure techniques such as sutures and staples are currently used in the clinic. These tissue-piercing wound closure techniques have several disadvantages such as the potential for causing inflammation, infections, and scar formation. Surgical sealants and tissue adhesives can address some of the disadvantages of current sutures and staples. An ideal tissue adhesive will demonstrate strong interfacial adhesion and cohesive strength to wet tissue surfaces. Most reported studies rely on the liquid-to-solid transition of organic molecules by taking advantage of polymerization and crosslinking reactions for improving the cohesive strength of the adhesives. Crosslinking reactions triggered using light are commonly used for increasing tissue adhesive strength since the reactions can be controlled spatially and temporally, providing the on-demand curing of the adhesives with minimum misplacements. In this review, we describe the recent advances in the field of naturally derived tissue adhesives and sealants in which the adhesive and cohesive strengths are modulated using photochemical reactions.

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Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive

Cited by 83 publications

References 47 publications

A Hyaluronic Acid Based Injectable Hydrogel Formed via Photo-Crosslinking Reaction and Thermal-Induced Diels-Alder Reaction for Cartilage Tissue Engineering

A Hyaluronic Acid Based Injectable Hydrogel Formed via Photo-Crosslinking Reaction and Thermal-Induced Diels-Alder Reaction for Cartilage Tissue Engineering

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers

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